ORCID Profile
0000-0003-1701-6896
Current Organisation
Altos Labs Inc
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Publisher: Elsevier BV
Date: 2018
Publisher: Springer Science and Business Media LLC
Date: 08-2017
Publisher: Public Library of Science (PLoS)
Date: 28-03-2016
Publisher: Cold Spring Harbor Laboratory
Date: 15-08-2021
DOI: 10.1101/2021.08.13.456238
Abstract: Dysregulation of intercellular communication is a well-established hallmark of aging. To better understand how this process contributes to the aging phenotype, we built scAgeCom, a comprehensive atlas presenting how cell-type to cell-type interactions vary with age in 23 mouse tissues. We first created an R package, scDiffCom, designed to perform differential intercellular communication analysis between two conditions of interest in any mouse or human single-cell RNA-seq dataset. The package relies on its own list of curated ligand-receptor interactions compiled from seven established studies. We applied this tool to single-cell transcriptomics data from the Tabula Muris Senis consortium and the Calico murine aging cell atlas. All the results can be accessed online, using a user-friendly, interactive web application ( scagecom.org ). The most widespread changes we observed include upregulation of immune system processes, inflammation and lipid metabolism, and downregulation of extracellular matrix organization, growth, development and angiogenesis. More specific interpretations are also provided.
Publisher: Elsevier
Date: 2021
Publisher: Frontiers Media SA
Date: 03-11-2022
DOI: 10.3389/FNAGI.2022.1016293
Abstract: The retinal pigment epithelium (RPE) and the choroid are ocular tissues with fundamental roles in supporting neuroretinal function. The pathogenesis of age-related macular degeneration (AMD), a leading cause of irreversible blindness for which aging is the highest risk factor is closely linked with progressive impairment of various functions of these tissues. Cellular senescence, marked by cell cycle arrest and secretion of proinflammatory factors, is known to be associated with aging and has been proposed as a potential driver of AMD. Here, we investigated the role played by intercellular communication in the RPE/choroid within the context of aging, senescence and AMD. We inferred cell–cell interactions in the RPE/choroid by applying CellChat and scDiffCom on a publicly available scRNA-seq dataset from three human donors with and without AMD. We identified age-regulated ligand and receptor genes by using limma on a separate publicly available bulk microarray dataset providing RPE/choroid s les at multiple time points. Cellular senescence was investigated by assigning a score to each cell and each s le of these scRNA-seq and microarray datasets, respectively, based on the expression of key signature genes determined by a previous senescence meta-analysis. We identified VEGF-, BMP-and tenascin-mediated pathways supporting some of the strongest cell–cell interactions between RPE cells, fibroblasts and choroidal endothelial cells and as strong intercellular communication pathways related to both aging and senescence. Their signaling strength was enhanced between subpopulations of cells having high senescence scores. Predominant ligands of these pathways were upregulated with age whereas predominant receptors were downregulated. Globally, we also observed that cells from AMD s les presented slightly bigger senescence scores than normal cells and that the senescence score positively correlated with age in bulk s les ( R = 0.26, value of p & 0.01). Hence, our analysis provides novel information on RPE/choroid intercellular communication that gives insights into the connection between aging, senescence and AMD.
Publisher: American Physical Society (APS)
Date: 05-04-2016
Publisher: American Physical Society (APS)
Date: 13-09-2016
Publisher: World Scientific Pub Co Pte Lt
Date: 10-2017
DOI: 10.1142/S0218271817430052
Abstract: We argue that the gravitational wave signal recently observed by the LIGO detectors provides a powerful tool to probe the fundamental structure of space and time. In particular, we properly model the inspiral phase of two merging black holes in a noncommutative spacetime and extract an upper bound on the scale of such quantum fuzziness at the order of the Planck scale. This improves previous constraints by [Formula: see text] orders of magnitude.
Publisher: Springer Science and Business Media LLC
Date: 17-06-2022
Location: United Kingdom of Great Britain and Northern Ireland
Location: Switzerland
Start Date: 2019
End Date: 2022
Funder: Human Frontier Science Program
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