ORCID Profile
0000-0002-0418-0999
Current Organisation
Harvard Medical School
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Publisher: Elsevier BV
Date: 09-2020
Publisher: Elsevier BV
Date: 06-2017
Publisher: Society for Neuroscience
Date: 17-03-2017
DOI: 10.1523/JNEUROSCI.3263-16.2017
Abstract: Alzheimer's disease (AD) is characterized by two hallmark molecular pathologies: amyloid aβ 1–42 and Tau neurofibrillary tangles. To date, studies of functional connectivity MRI (fcMRI) in in iduals with preclinical AD have relied on associations with in vivo measures of amyloid pathology. With the recent advent of in vivo Tau-PET tracers it is now possible to extend investigations on fcMRI in a s le of cognitively normal elderly humans to regional measures of Tau. We modeled fcMRI measures across four major cortical association networks [default-mode network (DMN), salience network (SAL), dorsal attention network, and frontoparietal control network] as a function of global cortical amyloid [Pittsburgh Compound B (PiB)-PET] and regional Tau (AV1451-PET) in entorhinal, inferior temporal (IT), and inferior parietal cortex. Results showed that the interaction term between PiB and IT AV1451 was significantly associated with connectivity in the DMN and salience. The interaction revealed that amyloid-positive (aβ + ) in iduals show increased connectivity in the DMN and salience when neocortical Tau levels are low, whereas aβ + in iduals demonstrate decreased connectivity in these networks as a function of elevated Tau-PET signal. This pattern suggests a hyperconnectivity phase followed by a hypoconnectivity phase in the course of preclinical AD. SIGNIFICANCE STATEMENT This article offers a first look at the relationship between Tau-PET imaging with F 18 -AV1451 and functional connectivity MRI (fcMRI) in the context of amyloid-PET imaging. The results suggest a nonlinear relationship between fcMRI and both Tau-PET and amyloid-PET imaging. The pattern supports recent conjecture that the AD fcMRI trajectory is characterized by periods of both hyperconnectivity and hypoconnectivity. Furthermore, this nonlinear pattern can account for the sometimes conflicting reports of associations between amyloid and fcMRI in in iduals with preclinical Alzheimer's disease.
Publisher: Elsevier BV
Date: 06-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 24-07-2013
Publisher: American Medical Association (AMA)
Date: 09-2014
No related grants have been discovered for Aaron Schultz.