ORCID Profile
0000-0002-6600-6507
Current Organisations
Cardiff University
,
Guangxi University
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Publisher: Elsevier BV
Date: 02-2005
Publisher: Wiley
Date: 26-02-2006
DOI: 10.1002/NME.1505
Publisher: Elsevier BV
Date: 2011
Publisher: Elsevier BV
Date: 03-2007
Publisher: Elsevier BV
Date: 04-2007
Publisher: Elsevier BV
Date: 11-2006
Publisher: American Association for the Advancement of Science (AAAS)
Date: 14-09-2022
DOI: 10.1126/SCITRANSLMED.ABN3758
Abstract: The management of antibiotic-resistant, bacterial biofilm infections in chronic skin wounds is an increasing clinical challenge. Despite advances in diagnosis, many patients do not derive benefit from current anti-infective/antibiotic therapies. Here, we report a novel class of naturally occurring and semisynthetic epoxy-tiglianes, derived from the Queensland blushwood tree ( Fontainea picrosperma) , and demonstrate their antimicrobial activity (modifying bacterial growth and inducing biofilm disruption), with structure/activity relationships established against important human pathogens. In vitro, the lead candidate EBC-1013 stimulated protein kinase C (PKC)–dependent neutrophil reactive oxygen species (ROS) induction and NETosis and increased expression of wound healing–associated cytokines, chemokines, and antimicrobial peptides in keratinocytes and fibroblasts. In vivo, topical EBC-1013 induced rapid resolution of infection with increased matrix remodeling in acute thermal injuries in calves. In chronically infected diabetic mouse wounds, treatment induced cytokine/chemokine production, inflammatory cell recruitment, and complete healing (in six of seven wounds) with ordered keratinocyte differentiation. These results highlight a nonantibiotic approach involving contrasting, orthogonal mechanisms of action combining targeted biofilm disruption and innate immune induction in the treatment of chronic wounds.
Publisher: Elsevier BV
Date: 09-2009
Publisher: Elsevier BV
Date: 2006
Publisher: Springer Science and Business Media LLC
Date: 02-09-2005
Publisher: Informa UK Limited
Date: 14-01-2009
Publisher: Springer Science and Business Media LLC
Date: 04-05-2006
Publisher: Wiley
Date: 2007
DOI: 10.1002/NME.1984
Publisher: Elsevier
Date: 2006
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Georgina Menzies.