Inna Uliyakina

DEFICIENCIES IN PATHOLOGICAL REPORTING OF COLORECTAL CANCER IN VICTORIA

Publisher: Wiley

Date: 09-2008

DOI: 10.1111/J.1445-2197.2008.04653.X

Abstract: Colorectal cancer (CRC) pathological reporting deficiencies have been shown to be common, with deviations from the suggested minimum dataset. Information from both surgeon and pathologist is necessary for a complete report. These deficiencies have been shown to be correctable with the use of synoptic reporting. We carried out an audit on a random s le of CRC pathological reports from the first 6 months of 2004 in Victoria, Australia, with the aim of documenting current CRC pathological reporting deficiencies. A random s le of pathological reports for CRC was obtained from the Cancer Council of Victoria. One hundred and sixteen of these reports were reviewed by a team of surgical and pathology trainees. Presence or absence of the various fields of the 1999 National Health and Medical Research Council minimum dataset for CRC reporting was recorded. There were deviations from the minimal dataset. Most notable was the absence of the information on the apical node, the presence of distant metastasis and perineural invasion. The opportunity exists for improvement in the pathological reporting of CRC in Victoria through the uniform introduction of synoptic reporting.

Current Treatment Approaches and Outcomes in the Management of Rectal Cancer Above the Age of 80

Publisher: MDPI AG

Date: 30-03-2021

DOI: 10.3390/CURRONCOL28020132

Abstract: Background: The number of cases of rectal cancer in our older cohort is expected to rise with our ageing population. In this study, we analysed patterns in treatment and the long-term outcomes of patients older than 80 years with rectal cancer across a health district. Methods: All cases of rectal cancer managed at the Illawarra Cancer Care Centre, Australia between 2006 and 2018 were analysed from a prospectively maintained database. Patients were stratified into three age groups: ≤65 years, 66–79 years and ≥80 years of age. The clinicopathological characteristics, operative and non-operative treatment approach and survival outcomes of the three groups were compared. Results: Six hundred and ninety-nine patients with rectal cancer were managed, of which 118 (17%) were aged 80 and above. Patients above 80 were less likely to undergo surgery (71% vs. 90%, p 0.001) or receive adjuvant/neoadjuvant chemoradiotherapy (p 0.05). Of those that underwent surgical resection, their tumours were on average larger (36.5 vs. 31.5 mm, p = 0.019) and 18 mm closer the anal verge (p = 0.001). On Kaplan–Meier analysis, those above 80 had poorer cancer-specific survival when compared to their younger counterparts (p = 0.032), but this difference was no longer apparent after the first year (p = 0.381). Conclusion: Patients above the age of 80 with rectal cancer exhibit poorer cancer-specific survival, which is accounted for in the first year after diagnosis. Priority should be made to optimise care during this period. There is a need for further research to establish the role of chemoradiotherapy in this population, which appears to be underutilised.

High-Content siRNA Screen Reveals Global ENaC Regulators and Potential Cystic Fibrosis Therapy Targets

Publisher: Elsevier BV

Date: 09-2013

DOI: 10.1016/J.CELL.2013.08.045

Abstract: Dysfunction of ENaC, the epithelial sodium channel that regulates salt and water reabsorption in epithelia, causes several human diseases, including cystic fibrosis (CF). To develop a global understanding of molecular regulators of ENaC traffic/function and to identify of candidate CF drug targets, we performed a large-scale screen combining high-content live-cell microscopy and siRNAs in human airway epithelial cells. Screening over 6,000 genes identified over 1,500 candidates, evenly ided between channel inhibitors and activators. Genes in the phosphatidylinositol pathway were enriched on the primary candidate list, and these, along with other ENaC activators, were examined further with secondary siRNA validation. Subsequent detailed investigation revealed ciliary neurotrophic factor receptor (CNTFR) as an ENaC modulator and showed that inhibition of (diacylglycerol kinase, iota) DGKι, a protein involved in PiP2 metabolism, downgrades ENaC activity, leading to normalization of both Na+ and fluid absorption in CF airways to non-CF levels in primary human lung cells from CF patients.

Protocol‐based approach to suspected appendicitis, incorporating the Alvarado score and outpatient antibiotics

Publisher: Wiley

Date: 05-2004

DOI: 10.1111/J.1445-1433.2004.02993.X

Signal to noise ratio based filter optimization in triple energy window scatter correction

Publisher: Wiley

Date: 08-2000

DOI: 10.1118/1.1287286

Abstract: Triple energy window (TEW) scatter correction estimates the contribution of scattered photons to the acquisition data by acquiring additional data through two narrow energy windows placed adjoined to the main (photopeak) energy window. The contribution is estimated by linear interpolation and then subtracted. Noise lification is reduced by filtering both the photopeak scintigram and the scatter estimate. We have studied the filter settings of each filter using a physical phantom filled with a 201Tl-solution resulting in count densities comparable to clinical studies. The performance of order-8 Butterworth filters at different cut-off frequencies (CoFs) were compared based on signal to noise ratios (SNRs). The highest SNRs were obtained when the noisy scatter information was strongly filtered with the CoF less than or equal to 0.07 cycles ixel (cpp). The best CoF for the filter of the photopeak image is object size dependent smaller objects require a higher CoF. For objects with a size near the SPECT spatial resolution (approximately 15 mm) the optimal CoF is equal to 0.18 cpp. For larger objects (31.8 mm) the highest SNR was obtained with a CoF equal to 0.13 cpp. A CoF equal to 0.16 cpp is a good compromise for all objects with a diameter equal to the spatial resolution or larger. These results depend on the initial signal to noise ratio of the acquisition data and so on the count density.

Wollongong Hospital

Location: Australia

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University Of Oxford

Location: United Kingdom of Great Britain and Northern Ireland

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Universidade De Lisboa Faculdade De Ciências

Location: Portugal

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Universidade Nova De Lisboa Instituto De Tecnologia Química E Biológica

Location: Portugal

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