ORCID Profile
0000-0002-5779-9330
Current Organisations
Université Laval
,
Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale
,
CERVO Brain Research Centre
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Publications
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Publisher: eLife Sciences Publications, Ltd
Date: 13-10-2017
DOI: 10.7554/ELIFE.28270
Abstract: KCC2 is a neuron-specific K+-Cl– cotransporter essential for establishing the Cl- gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis and AMPA receptor confinement. Aberrant KCC2 function contributes to human neurological disorders including epilepsy and neuropathic pain. Using functional proteomics, we identified the KCC2-interactome in the mouse brain to determine KCC2-protein interactions that regulate KCC2 function. Our analysis revealed that KCC2 interacts with erse proteins, and its most predominant interactors play important roles in postsynaptic receptor recycling. The most abundant KCC2 interactor is a neuronal endocytic regulatory protein termed PACSIN1 (SYNDAPIN1). We verified the PACSIN1-KCC2 interaction biochemically and demonstrated that shRNA knockdown of PACSIN1 in hippoc al neurons increases KCC2 expression and hyperpolarizes the reversal potential for Cl-. Overall, our global native-KCC2 interactome and subsequent characterization revealed PACSIN1 as a novel and potent negative regulator of KCC2.
Sensory Afferents Use Different Coding Strategies for Heat and Cold
Publisher: Elsevier BV
Date: 05-2018
DOI: 10.1016/J.CELREP.2018.04.065
Abstract: Primary afferents transduce environmental stimuli into electrical activity that is transmitted centrally to be decoded into corresponding sensations. However, it remains unknown how afferent populations encode different somatosensory inputs. To address this, we performed two-photon Ca
The International Brain Initiative: enabling collaborative science
Publisher: Elsevier BV
Date: 12-2021
International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts
Publisher: Elsevier BV
Date: 2020
DOI: 10.1016/J.NEURON.2020.01.002
Abstract: The International Brain Initiative (IBI) has been established to coordinate efforts across existing and emerging national and regional brain initiatives. This NeuroView describes how to be involved and the new opportunities for global collaboration that are emerging between scientists, scientific societies, funders, industry, government, and society.
Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice
Publisher: Springer Science and Business Media LLC
Date: 27-01-2017
DOI: 10.1038/SREP41432
Abstract: The loss of nigrostriatal dopamine neurons in Parkinson’s disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D 1 or D 2 dopamine receptor. Consequences on MSNs expressing both receptors (D 1 /D 2 MSNs) are currently unknown. We looked for changes induced by dopamine denervation in the density, regional distribution and morphological features of D 1 /D 2 MSNs, by comparing 6-OHDA-lesioned double BAC transgenic mice ( Drd1a -tdTomato/ Drd2 -EGFP) to sham-lesioned animals. D 1 /D 2 MSNs are uniformly distributed throughout the dorsal striatum (1.9% of MSNs). In contrast, they are heterogeneously distributed and more numerous in the ventral striatum (14.6% in the shell and 7.3% in the core). Compared to D 1 and D 2 MSNs, D 1 /D 2 MSNs are endowed with a smaller cell body and a less profusely arborized dendritic tree with less dendritic spines. The dendritic spine density of D 1 /D 2 MSNs, but also of D 1 and D 2 MSNs, is significantly reduced in 6-OHDA-lesioned mice. In contrast to D 1 and D 2 MSNs, the extent of dendritic arborization of D 1 /D 2 MSNs appears unaltered in 6-OHDA-lesioned mice. Our data indicate that D 1 /D 2 MSNs in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson’s disease.
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Publisher: eLife Sciences Publications, Ltd
Date: 2017
Related Organisations
University Of Texas Southwestern Medical Center At Dallas
Location: United States of America
Centre Intégré Universitaire De Santé Et De Services Sociaux De La Capitale-Nationale
Location: Canada
Related Funding Activities
No related grants have been discovered for Yves De Koninck.