ORCID Profile
0000-0002-2488-4221
Current Organisation
Yokohama National University
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Publisher: Elsevier BV
Date: 03-2022
DOI: 10.1016/J.JBIOSC.2021.12.003
Abstract: Hair follicle dermal papilla cells (DPCs) are specialized mesenchymal cells that play pivotal roles in hair formation, growth, and cycles, and they are considered as a cell source in hair regenerative medicine. Rodent dermal papilla cells have been shown to induce de novo hair follicle generation in the skin of recipients following transplantation, suggesting that dermal papilla cells can reprogram epidermal microenvironments. However, human DPCs (hDPCs) lose their ability to generate de novo hair follicles under conventional culture methods. We investigated the effects of electrical stimulation (ES) on hDPCs to restore the depressed trichogenic activity. We demonstrated that ES with a polypyrrole (PPy)-modified electrode upregulated trichogenic gene expression in hDPCs in vitro, and the activated cells when transplanted into mice generated double the number of hairs compared to that without the ES. Using specific inhibitors, we revealed that the mechanisms behind the electrical activation are associated with voltage-gated ion channels. Further, ES can be adapted for hDPCs from a patient with androgenic alopecia. Thus, this approach is potentially beneficial in preparing hDPCs for hair regenerative medicine.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5TB00574D
Abstract: The development of inherently conducting polymers as controllable rogrammable drug delivery systems has attracted significant interest in medical bionics, and the interfacial properties of the polymers, in particular, protein adsorption characteristics, is integral to the stability of the overall performance.
Publisher: Wiley
Date: 25-03-2014
Publisher: Wiley
Date: 30-03-2018
Publisher: Informa UK Limited
Date: 24-09-2013
DOI: 10.1080/08927014.2013.830110
Abstract: The ability to control the interaction between proteins and cells with biomaterials is critical for the effective application of materials for a variety of biomedical applications. Herein, the surface modification of the biological dopant dextran sulphate-doped polypyrrole (PPy-DS) with poly(ethylene glycol) to generate a biomaterial interface that is highly resistant to protein and cellular adhesion is described. Thiolated poly(ethylene glycol) (PEG-thiol) was covalently bound to PPy-DS backbone via a thiol-ene reaction. The surface resistance to an extracellular matrix protein fibronectin increased with increasing molecular weight and concentration of PEG-thiol, and was further optimised via increasing the reaction temperature and the pH of the reactant aqueous solution. Optimised surface modification conditions substantially reduced interfacial protein adsorption, with the complete inhibition of adhesion and colonisation by primary mouse myoblasts. PEG-thiol-modified inherently conducting polymers are highly protein resistant multifunctional materials that are promising compounds for a range of biomedical and aquatic applications.
Publisher: Elsevier BV
Date: 07-2023
Publisher: Informa UK Limited
Date: 03-07-2015
DOI: 10.1080/08927014.2015.1065487
Abstract: Diatoms are a major component of microbial biofouling layers that develop on man-made surfaces placed in aquatic environments, resulting in significant economic and environmental impacts. This paper describes surface functionalisation of the inherently conducting polymers (ICPs) polypyrrole (PPy) and polyaniline (PANI) with poly(ethylene glycol) (PEG) and their efficacy as fouling resistant materials. Their ability to resist interactions with the model protein bovine serum albumin (BSA) was tested using a quartz crystal microbalance with dissipation monitoring (QCM-D). The capacity of the ICP-PEG materials to prevent settlement and colonisation of the fouling diatom Amphora coffeaeformis (Cleve) was also assayed. Variations were demonstrated in the dopants used during ICP polymerisation, along with the PEG molecular weight, and the ICP-PEG reaction conditions, all playing a role in guiding the eventual fouling resistant properties of the materials. Optimised ICP-PEG materials resulted in a significant reduction in BSA adsorption, and > 98% reduction in diatom adhesion.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7SM02187A
Abstract: Strategies for controlling the properties of gelatin methacryloyl hydrogels are elucidated, with applications for biofabrication and tissue engineering.
Publisher: Springer International Publishing
Date: 2015
Publisher: IOP Publishing
Date: 10-02-2015
Publisher: IOP Publishing
Date: 23-03-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7BM01156C
Abstract: PEDOT films were electrochemically polymerised with synthetic and biological dopants, characterised, and their interactions with proteins and neuronal cells investigated.
No related grants have been discovered for Binbin Zhang Molino.