ORCID Profile
0000-0003-2681-1197
Current Organisation
The University of Newcastle
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Publisher: Elsevier BV
Date: 11-2011
Publisher: Elsevier BV
Date: 10-2008
Publisher: Elsevier BV
Date: 05-2014
Publisher: Elsevier BV
Date: 02-2013
Publisher: Elsevier BV
Date: 02-2012
Publisher: Elsevier BV
Date: 12-2010
Publisher: MDPI AG
Date: 25-11-2019
DOI: 10.3390/IJMS20235924
Abstract: Metastases in thyroid cancer are associated with aggressive disease and increased patient morbidity, but the factors driving metastatic progression are unclear. The precursor for nerve growth factor (proNGF) is increased in primary thyroid cancers, but its expression or significance in metastases is not known. In this study, we analysed the expression of proNGF in a retrospective cohort of thyroid cancer lymph node metastases (n = 56), linked with corresponding primary tumours, by automated immunohistochemistry and digital quantification. Potential associations of proNGF immunostaining with clinical and pathological parameters were investigated. ProNGF staining intensity (defined by the median h-score) was significantly higher in lymph node metastases (h-score 94, interquartile range (IQR) 50–147) than in corresponding primary tumours (57, IQR 42–84) (p = 0.002). There was a correlation between proNGF expression in primary tumours and corresponding metastases, where there was a 0.68 (95% CI 0 to 1.2) increase in metastatic tumour h-score for each unit increase in the primary tumour h-score. However, larger tumours (both primary and metastatic) had lower proNGF expression. In a multivariate model, proNGF expression in nodal metastases was negatively correlated with lateral neck disease and being male. In conclusion, ProNGF is expressed in locoregional metastases of thyroid cancer and is higher in lymph node metastases than in primary tumours, but is not associated with high-risk clinical features.
Publisher: IEEE
Date: 2012
Publisher: Elsevier BV
Date: 02-2019
Publisher: Elsevier BV
Date: 08-2013
Publisher: Elsevier BV
Date: 04-2021
Publisher: Elsevier BV
Date: 12-2016
Publisher: Springer International Publishing
Date: 2021
Publisher: Elsevier BV
Date: 09-2020
Publisher: Elsevier BV
Date: 11-2015
Publisher: Springer London
Date: 2006
Publisher: Informa UK Limited
Date: 03-2013
Publisher: Elsevier
Date: 2016
Publisher: Informa UK Limited
Date: 04-2004
Publisher: Elsevier BV
Date: 10-2008
Publisher: Trans Tech Publications, Ltd.
Date: 04-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.508.11
Abstract: Bypass pneumatic conveying systems provide a passive capability to reduce conveying velocity and therefore reduce attrition and abrasion in the process of conveying many fragile and erosive particulate solids. Because of these capabilities, bypass pneumatic conveying systems have been used in coal-fired power stations for removing fly ash for the last couple of decades. In bypass systems, the differential pressure between bypass pipe and main pipe as well as the pipeline pressure drop are two of most significant parameters as differential pressure represents the aeration mechanism within the pipeline while pressure drop is an essential parameter for bypass pneumatic conveying system design. In bypass systems, these two parameters are determined not only by the turbulent mode of the gas solids two-phase flow but also by the bypass configurations. The objective of this study was to experimentally investigate the differential pressure between bypass pipe and main pipe as well as the pressure drop during the bypass pneumatic conveying of fly ash. Pneumatic conveying tests in bypass systems and a conventional pipeline were carried out in this study. The bypass pipeline was a 79 mm diameter main pipe with a 27 mm inner diameter bypass pipe with orifice plate flute arrangement. Fly ash was discharged to the system from the bottom of a positive pressure blow tank. The receiving bin was mounted on load cells for measuring the mass accumulation. In order to monitor real time behavior of the system, pressure transmitters were used to measure the gauge pressure. Differential pressure transmitters were employed in the system for measuring the pressure difference between the bypass pipe and main pipe. Differential pressure results between bypass pipe and main pipe in the process of conveying fly ash showed that the pressure before the orifice plate in the bypass pipe was higher than that in main pipe as a result of orifice plate airflow resistance. Therefore, air came into main pipe and aerated the material continuously. The differential pressure also illustrated that the particulate may go into the bypass pipe as pressure in the bypass pipe after orifice plate is lower than that in main pipe. The pipeline pressure drop results also showed that pressure drop was higher than in the conventional system when using the same operating parameters due to the increase of friction. The influences of bypass configurations on pressure drop of bypass system were also discussed.
Publisher: Elsevier BV
Date: 11-2013
Publisher: Elsevier BV
Date: 07-2011
Publisher: Springer London
Date: 31-07-2013
Publisher: Elsevier BV
Date: 08-2014
Publisher: Springer London
Date: 2010
Publisher: Informa UK Limited
Date: 12-03-2015
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 10-2008
Publisher: Elsevier BV
Date: 06-2009
Publisher: Elsevier BV
Date: 02-2014
Publisher: Informa UK Limited
Date: 11-2018
DOI: 10.2147/PPA.S183938
Publisher: Elsevier BV
Date: 12-2014
Publisher: Elsevier BV
Date: 2022
Publisher: Elsevier BV
Date: 03-2022
Publisher: Elsevier BV
Date: 05-2008
Publisher: Wiley
Date: 11-2004
Publisher: Elsevier BV
Date: 06-2018
Publisher: Elsevier BV
Date: 10-2017
Publisher: Elsevier BV
Date: 05-2022
Publisher: Trans Tech Publications, Ltd.
Date: 05-2011
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.239-242.3323
Abstract: The material pulse flow structure within the fluidized dense phase pneumatic conveying of flyash powder was studied using the Electrical Capacitance Tomography (ECT). Decomposition of the bulk density levels within the pipe cross-sectional area were obtained and statistical analysis of bulk density waves were performed. The results suggest that the pulse litude and duration obeyed the Weibull and lognormal distributions. In addition, bulk density factor was found to have a linear relationship with pulse litude however, it is independent of pulse duration.
Publisher: Elsevier
Date: 2001
Publisher: Elsevier BV
Date: 2014
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 03-2020
Publisher: Springer Science and Business Media LLC
Date: 20-11-2018
DOI: 10.1038/S41366-018-0250-7
Abstract: Although weight change has been studied in relation to many in idual chronic conditions, limited studies have focused on weight change and multimorbidity. This study examines the relationship between short-term weight change and the accumulation of multimorbidity in midlife. We used data from 7357 women aged 45-50 years without a history of any chronic conditions. The women were surveyed approximately every 3 years from 1996 to 2016. Associations between short-term weight change and accumulation of multimorbidity (two or more of nine chronic conditions) over each 3-year period, adjusting for baseline body mass index (BMI) or time-varying BMI (3-year period), were examined using repeated measures models. Short-term weight change was categorised into seven groups of annual weight change from high weight loss ( ≤ -5%) to high weight gain (> + 5%). Over 20 years, 60.4% (n = 4442) of women developed multimorbidity. Baseline BMI, time-varying BMI and short-term weight gain were all associated with the accumulation of multimorbidity. After controlling for sociodemographic, lifestyle factors and menopausal status, high weight gain was associated with a 25% increased odds of multimorbidity (odds ratio (OR) 1.25, 95% confidence interval (CI) 1.08-1.45) compared with maintaining a stable weight. The results were consistent among models adjusting for baseline BMI (OR 1.24, 95% CI 1.07-1.44) or time-varying BMI (OR 1.34, 95% CI 1.16-1.54). Weight loss was associated with increased odds of multimorbidity in women with normal BMI (baseline or time-varying). Short-term weight gain is associated with significantly increased odds of multimorbidity in mid-aged women. This association is independent from baseline BMI (at 45-50 years) and time-varying BMI. These findings support a persistent weight management regime and prevention of weight gain throughout women's midlife.
Publisher: Trans Tech Publications, Ltd.
Date: 04-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.508.6
Abstract: Dense phase pneumatic conveying is preferable over dilute phase conveying in many industries as lower transport velocities are beneficial due to reduced attrition of the particles and reduced wear. However, dense phase conveying is critically dependent on the physical properties of the materials to be conveyed. For many materials which are either erosive or fragile, they do not exhibit the physical properties required to be conveyed reliably in a low velocity, dense phase flow regime. This can be serious problem in the food, chemical and pharmaceutical industries. One satisfactory approach which has been widely applied is the use of bypass systems. Bypass pneumatic conveying systems provide the capacity of transporting some materials that are not naturally suitable for dense phase flow. Bypass pneumatic conveying systems also provide a passive capability to reduce minimum particulate transport velocities. In this study, pneumatic conveying experiments were carried out in a 79 mm diameter main pipe with a 27 mm inner diameter bypass pipe with orifice plate flute arrangement. Alumina, fly ash and sand were conveyed in the tests. High speed camera visualization was employed to study the flow regimes of bypass pneumatic transport systems and investigate the mechanism of material blockage inhibition provided by these systems. For alumina and fly ash, it was found that particulate material blockages were inhibited in bypass systems due to the air penetration into the particulate volume as a result of orifice plate airflow resistance. For the bypass pneumatic conveying of sand, the splitting of a long plug into two smaller plugs was observed. One of the primary concerns of bypass system is the wear of the bypass line. Material such as alumina is inherently abrasive by nature. For internal bypass systems, there is limited ability to monitor the state of the inner bypass tube while in operation. The particle velocity in the pipeline has been measured from the high speed video of the flow. The experimental result also showed that the conveying velocity of bypass system is much lower when compared conventional single bore pipelines. Based on the models developed for the assessment of service life of pneumatic conveying pipelines, the thickness loss of the bypass pipe has been estimated. It has been estimated that for a 3mm bypass tube wall thickness, a wear hole is created in approximately 2.5 years for a particle velocity of 3 m/s and 4 months for a particle velocity of 10 m/s.
Publisher: AME Publishing Company
Date: 12-2019
Publisher: Wiley
Date: 28-01-2005
Publisher: Trans Tech Publications, Ltd.
Date: 05-2011
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMR.239-242.112
Abstract: This paper reports the current development of technologies to analyse the conveying performance of bypass low velocity dense phase pneumatic conveying system for transporting powder bulk materials and slug flow low velocity dense phase pneumatic conveying system for transporting granular sized bulk materials. It reveals that the bypass system can be operated at a lowered air velocity than conventional pipe line and slug flow system can be also controlled to operate at a lower velocity zone. Hence these technologies have the potential to extend the conveying capability of a pneumatic conveying system to a broader range of materials, also provide better performance in reduction in pipe wear and product degradation.
Publisher: Elsevier BV
Date: 02-2019
Publisher: Elsevier BV
Date: 10-2009
Publisher: Springer Science and Business Media LLC
Date: 25-08-2015
Publisher: Elsevier BV
Date: 03-2016
Publisher: Harborside Press, LLC
Date: 04-2018
Publisher: Springer London
Date: 2010
Publisher: Elsevier BV
Date: 06-2019
Publisher: Elsevier BV
Date: 08-2017
Publisher: Springer International Publishing
Date: 29-08-2014
Publisher: Springer International Publishing
Date: 29-08-2014
Publisher: Elsevier BV
Date: 07-2011
Publisher: Springer London
Date: 31-07-2013
Publisher: Informa UK Limited
Date: 2003
Publisher: Association for Materials Protection and Performance (AMPP)
Date: 02-2012
DOI: 10.5006/1.3683231
Publisher: Elsevier BV
Date: 2022
Publisher: Informa UK Limited
Date: 2003
Publisher: Informa UK Limited
Date: 2003
Publisher: Elsevier BV
Date: 03-2014
Publisher: Elsevier BV
Date: 10-2021
Publisher: Trans Tech Publications, Ltd.
Date: 06-2010
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.26-28.1190
Abstract: The pressure drop predictions across a bypass pipeline in dense phase pneumatic conveying were investigated numerically. The simulation was conducted using the commercial Computational Fluid Dynamic (CFD) software Fluent with the Euler- Euler model accounting for four-way coupling. Experiments and calculations were conducted using flyash powder conveyed in a horizontal pipeline. The influence of the pipe length on pressure drop prediction was also investigated. The results indicate that pressure prediction of the CFD simulation model for a bypass pipe is promising. The conclusion is that this investigation can offer improved insight and initial design modelling capability for bypass pneumatic conveying systems.
No related grants have been discovered for Mark Jones.