ORCID Profile
0000-0002-3554-2673
Current Organisation
CHU-Sainte Justine Research Center
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Publisher: Elsevier BV
Date: 2019
Publisher: Elsevier BV
Date: 2022
Publisher: American Society for Clinical Investigation
Date: 23-05-2022
Publisher: Elsevier BV
Date: 03-2020
Publisher: Elsevier BV
Date: 05-2021
Publisher: Springer Science and Business Media LLC
Date: 15-02-2019
DOI: 10.1038/S41467-019-08800-2
Abstract: The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article.
Publisher: Oxford University Press (OUP)
Date: 28-02-2021
DOI: 10.1093/NAR/GKAB118
Abstract: Vertebrate genomes contain major (& .5%) and minor (& .5%) introns that are spliced by the major and minor spliceosomes, respectively. Major intron splicing follows the exon-definition model, whereby major spliceosome components first assemble across exons. However, since most genes with minor introns predominately consist of major introns, formation of exon-definition complexes in these genes would require interaction between the major and minor spliceosomes. Here, we report that minor spliceosome protein U11-59K binds to the major spliceosome U2AF complex, thereby supporting a model in which the minor spliceosome interacts with the major spliceosome across an exon to regulate the splicing of minor introns. Inhibition of minor spliceosome snRNAs and U11-59K disrupted exon-bridging interactions, leading to exon skipping by the major spliceosome. The resulting aberrant isoforms contained a premature stop codon, yet were not subjected to nonsense-mediated decay, but rather bound to polysomes. Importantly, we detected elevated levels of these alternatively spliced transcripts in in iduals with minor spliceosome-related diseases such as Roifman syndrome, Lowry–Wood syndrome and early-onset cerebellar ataxia. In all, we report that the minor spliceosome informs splicing by the major spliceosome through exon-definition interactions and show that minor spliceosome inhibition results in aberrant alternative splicing in disease.
Publisher: Elsevier BV
Date: 03-2019
Publisher: Elsevier BV
Date: 06-2021
No related grants have been discovered for Justine Rousseau.