ORCID Profile
0000-0001-9578-2612
Current Organisation
Sydney Children's Hospitals Network Randwick and Westmead
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Publisher: Wiley
Date: 25-08-2023
DOI: 10.1111/AJD.14146
Publisher: Wiley
Date: 10-2022
DOI: 10.1111/HIS.14756
Publisher: Wiley
Date: 29-11-2005
DOI: 10.1111/J.1463-1318.2005.00899.X
Abstract: The purpose of this study was to determine the accuracy of synergic body coil MRI using SPIR technique without contrast, in the determination of fistula characteristics in patients with clinically positive signs. This was a case-series prospective study including 29 consecutive patients with clinically suspected fistulas-in-ano. The standard synergic body coil was used and all patients had T2-weighted SPIR sequences. One radiologist, without prior knowledge of the clinical examination, analysed images and noted the presence of the fistula, its classification and the presence and number of any collections or extensions. The surgeon noted the MRI findings and looked for lesions suggested on MRI. The results of the MRI and surgical assessments were then compared. Results of surgical exploration while the surgeon was aware of MRI results were considered as the gold standard of surgical anatomy. Twenty-three (79.31%) of 29 fistula tracks were seen on MRI which correctly determined the type of all fistulas. In the six cases where the fistula was not seen on MRI, five were low trans-sphincteric and one was rectovaginal. MRI identified 8 of 10 collections. The synergic body coil MRI with SPIR sequencing without endoanal coils had a high accuracy in the diagnosis of high fistulas collections, complex fistulas and extensions.
Publisher: Springer International Publishing
Date: 2022
Publisher: Elsevier BV
Date: 02-2023
Publisher: Informa UK Limited
Date: 2006
DOI: 10.1080/03014460600802478
Abstract: The aim of the study was to create reference values for weight, height and body mass index (BMI) of school children living in Tehran. METHOD AND SAMPLES: The study subjects consisted of 1,420 girls between 6 and 17 years of age and 1,515 boys between 6 and 15 years of age. S les were collected by a multistage s ling method from schools in different areas of Tehran. All participants were established to be healthy and their height, weight and BMI evaluated. Reference standard values estimated by the LMS method using LMS Light software and 3rd, 5th, 10th, 25th, 50th, 75th, 90th, 97th and 85th (only for BMI) centiles were constructed and the results compared with US reference values. The centiles provided a good fit to the data. In boys, there were some significant differences of mean standard deviation scores (SDS) of height and BMI from zero, but there were no significant differences in weight. In girls, the mean SDS of height, weight and BMI were significantly lower than zero, especially for 7-9 years of age. Among 12-13-year-old girls, the mean SDS of height, weight and BMI came closer to zero, and the differences were not significant. Thereafter, although girls seemed to be shorter than US reference measures, their weight and BMI did not differ from reference values significantly. Our results for boys between 6 and 15 years are comparable with US reference values however, the US reference values, especially for height, are not applicable for Iranian girls between 6 and 17 years.
Publisher: Wiley
Date: 17-06-2023
DOI: 10.1002/UOG.26296
Publisher: Elsevier BV
Date: 02-2023
Publisher: Wiley
Date: 15-02-2022
DOI: 10.1111/APHA.13795
Abstract: The current study investigated the impact of maternal obesity on placental phenotype in relation to fetal growth and sex. Female C57BL6/J mice were fed either a diet high in fat and sugar or a standard chow diet, for 6 weeks prior to, and during, pregnancy. At day 19 of gestation, placental morphology and mitochondrial respiration and dynamics were assessed using high‐resolution respirometry, stereology, and molecular analyses. Diet‐induced maternal obesity increased the rate of small for gestational age fetuses in both sexes, and increased blood glucose concentrations in offspring. Placental weight, surface area, and maternal blood spaces were decreased in both sexes, with reductions in placental trophoblast volume, oxygen diffusing capacity, and an increased barrier to transfer in males only. Despite these morphological changes, placental mitochondrial respiration was unaffected by maternal obesity, although the influence of fetal sex on placental respiratory capacity varied between dietary groups. Moreover, in males, but not females, maternal obesity increased mitochondrial complexes (II and ATP synthase) and fission protein DRP1 abundance. It also reduced phosphorylated AMPK and capacity for lipid synthesis, while increasing indices of oxidative stress, specifically in males. In females only, placental mitochondrial biogenesis and capacity for lipid synthesis, were both enhanced. The abundance of uncoupling protein‐2 was decreased by maternal obesity in both fetal sexes. Maternal obesity exerts sex‐dependent changes in placental phenotype in association with alterations in fetal growth and substrate supply. These findings may inform the design of personalized lifestyle interventions or therapies for obese pregnant women.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 13-03-2021
DOI: 10.1097/PGP.0000000000000766
Abstract: Melanocytic pigmentation occurs in multiple sites in the lower female genital tract, but is rare within benign cysts of the vulva. We report 3 patients with multiloculated cystic lesions of the vulvar vestibule exhibiting prominent melanocytic pigmentation. The current cases differ from a previous report of melanosis in a Bartholin gland cyst in that the population of melanocytes occupies the acinar structures of the gland, rather than a squamous-lined surface. A similar cell population is demonstrated by immunoperoxidase methods in a fourth patient’s nonpigmented gland, suggesting that melanin production may arise in a native, rather than metaplastic, cell population.
Publisher: Springer Science and Business Media LLC
Date: 2023
DOI: 10.1038/S41591-022-02142-1
Abstract: Pregnancy loss and perinatal death are devastating events for families. We assessed ‘genomic autopsy’ as an adjunct to standard autopsy for 200 families who had experienced fetal or newborn death, providing a definitive or candidate genetic diagnosis in 105 families. Our cohort provides evidence of severe atypical in utero presentations of known genetic disorders and identifies novel phenotypes and disease genes. Inheritance of 42% of definitive diagnoses were either autosomal recessive (30.8%), X-linked recessive (3.8%) or autosomal dominant (excluding de novos, 7.7%), with risk of recurrence in future pregnancies. We report that at least ten families (5%) used their diagnosis for preimplantation (5) or prenatal diagnosis (5) of 12 pregnancies. We emphasize the clinical importance of genomic investigations of pregnancy loss and perinatal death, with short turnaround times for diagnostic reporting and followed by systematic research follow-up investigations. This approach has the potential to enable accurate counseling for future pregnancies.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 14-01-2020
Publisher: Elsevier BV
Date: 09-2021
Publisher: BMJ
Date: 04-2021
Abstract: We present the case of a baby boy, with antenatal finding of bilateral enlarged echogenic lungs, who developed severe postnatal respiratory failure. Two important differential diagnoses, which have an impact on antenatal and postnatal management, are discussed. Fetal ultrasound, MRI and postmortem MRI images are presented and findings correlated with the autopsy findings.
Publisher: Wiley
Date: 18-10-2005
DOI: 10.1111/J.1463-1318.2005.00878.X
Abstract: The aim of this study was to assess the prevalence of end colostomy complications and the evaluation of factors influencing outcome. Three hundred and thirty patients with end colostomy were studied. All patient were recalled for examination for recent complications. Early complications included stoma site pain, early dermal irritation (during the first month after surgery), mucosal bleeding, stomal prolapse and psychosocial complications. Late complications included peristomal hernia, stomal stenosis, late dermal irritation (after the first month), stomal retraction, stomal necrosis and other stoma complications (perforation, fistula etc.). Probable underlying factors were studied. To evaluate risk factors affecting complications, univariable analysis and then multivariable analysis by binary logistic regression was performed. One hundred and one (30.6%) patients had no complications and the remainder had at least one of early or late complications. Overall, psychosocial complications, 56.4% mucosal bleeding, 34.5% early dermal irritation, 23.5% were the most frequent complications. Peristomal hernia (11.2%) was the most common late complication. Those aged > 40 years had significant associations with psychosocial problem (OR = 2.77), mucosal haemorrhage (OR = 2.19), and early dermal irritation (OR = 3.14). The risks of peristomal hernia and early dermal irritation are greater in the patients with BMI > 25 kg/m2 (OR = 2.08 and 2.55, respectively). The risk of most prevalent complications of colostomy construction increases in elder patients. The high prevalence of psychosocial and skin problems in patients with a colostomy, needs special attention especially from the viewpoint of education by trained stoma nurses and preparation of standard equipment.
Publisher: Informa UK Limited
Date: 2006
DOI: 10.1080/03014460600909372
Abstract: The aim of this study was to determine the age of appearance of secondary sexual characteristics in Iranian girls living in Tehran. A cross-sectional study was conducted between 2003 and 2004 on 1420 6-17-year-old females in different parts of Tehran. Data were collected on the basis of a multistage probability s ling. Secondary sexual characteristics were evaluated by inspection and palpation, and were recorded according to Tanner staging. The subjects were asked about the occurrence of menarche and the age of its onset. Generalized additive logistic modelling was used for the analysis of data. The median age (percentile 10-percentile 90) of Tanner 2 of breast development (B2) and Tanner 2 of pubic hair growth (P2) among 1136 girls was 9.74 years (8.23-11.94) and 10.49 years (8.86-12.17), respectively. The ages of the 2.5 percentile for B2 and P2 were 7.42 and 7.03 years, respectively, so the onset of puberty at < 7 years and 5 months is considered precocious in this population. The median age of menarche in 399 girls was 12.68 years (11.27-15.96).
Location: Australia
No related grants have been discovered for Ali Moghimi.