ORCID Profile
0000-0002-0171-6495
Current Organisations
Kyoto University
,
Garvan Institute of Medical Research
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Publisher: John Libbey Eurotext
Date: 09-2015
Publisher: Wiley
Date: 24-08-2015
DOI: 10.1111/JDV.13258
Publisher: Informa UK Limited
Date: 04-11-2016
Publisher: Wiley
Date: 06-05-2016
Publisher: John Libbey Eurotext
Date: 09-2022
Publisher: Wiley
Date: 21-06-2017
Publisher: Wiley
Date: 13-08-2016
DOI: 10.1111/JDV.13873
Publisher: Wiley
Date: 24-06-2015
Publisher: Wiley
Date: 31-08-2015
DOI: 10.1111/JDV.13287
Publisher: Wiley
Date: 27-01-2023
Publisher: Wiley
Date: 07-04-2023
Abstract: Mast cells (MCs) are immune cells residing in tissues and playing indispensable roles in maintaining homeostasis and inflammatory states. Skin lesions associated with atopic dermatitis (AD) and type 2 skin inflammation display an increment in MCs, which have both pro‐ and anti‐inflammatory effects. The direct and indirect activations of skin MCs by environmental factors such as Staphylococcus aureus can instigate type 2 skin inflammation in AD with poorly understood mechanisms. Furthermore, both IgE‐dependent and ‐independent degranulation of MCs contribute to pruritus in AD. Conversely, MCs suppress type 2 skin inflammation by promoting Treg expansion through IL‐2 secretion in the spleen. Moreover, skin MCs can upregulate gene expression involved in skin barrier function, thus mitigating AD‐like inflammation. These functional variances of MCs in AD could stem from differences in experimental systems, their localization, and origins. In this review, we will focus on how MCs are maintained in the skin under homeostatic and inflammatory conditions, and how they are involved in the pathogenesis of type 2 skin inflammation.
Publisher: Elsevier BV
Date: 08-2019
Publisher: Cold Spring Harbor Laboratory
Date: 05-03-2022
DOI: 10.1101/2022.03.04.483030
Abstract: Mast cells (MCs) are tissue-resident immune cells that are classified into two subsets in mice: connective tissue-type MCs (CTMCs) and mucosal type MCs (MMCs). Although both CTMCs and MMCs can be induced from bone marrow (BM)-derived hematopoietic stem cells (HSCs) in vitro, recent research on MC ontogeny has revealed that MMCs are maintained with a supply of BM-derived HSCs, while CTMCs are maintained locally by self-proliferation in steady state in vivo . However, how CTMCs, such as skin MCs, are maintained in an inflammatory state such as atopic dermatitis (AD) remains to be fully elucidated. Methods: MC903-induced AD model was used to identify BM-derived MCs in the skin. The infiltration and proliferation of MCs were evaluated by flow cytometry using CD45.1 BM-chimera mice and parabiosis. BM-derived MCs in AD-like skin were compared to resident MCs (rMCs) in gene expressions by RNA sequence analysis. The fate of BM-derived MCs in AD-like skin was investigated for expressions of CTMC markers and responses to compound 48/80. Results: In AD-like skin, significant increase of both rMCs and BM-derived MCs was observed. BM-derived MCs were derived from circulating MC progenitors (MCps) and were distinguished from rMCs by integrinβ7 expression, which was gradually downregulated in the skin. RNA sequence analysis showed that integrinβ7 + MCs in the skin shared characteristics of both MMC and CTMC. Integrinβ7 + MCs proliferated in situ and acquired the CTMC phenotypes in AD-like skin. Conclusions: Skin MCs are maintained in AD-like skin by both local proliferation of rMCs and infiltration roliferation of BM-derived MCs, which differentiate toward CTMC in the skin.
Publisher: Elsevier BV
Date: 08-2021
Publisher: John Libbey Eurotext
Date: 09-2016
Publisher: Medical Journals Sweden AB
Date: 2015
Publisher: Oxford University Press (OUP)
Date: 06-06-2016
DOI: 10.1111/BJD.14542
Publisher: S. Karger AG
Date: 16-12-2014
DOI: 10.1159/000370304
Abstract: Rhinoplasty is a plastic surgery procedure to reconstruct the nose. Silicone alloplastic materials are most widely used as implants for rhinoplasty, but calcification on the surface occurs with long-term usage. Herein, we report a case of gruel-like calcification approximately 50 years after silicone implant rhinoplasty. In this case, calcification on the silicone surface might have transformed into gruel-like deposits, which presented as a subcutaneous mass at the dorsal area of the nose. The precise mechanism is unclear a pH change in the tissue might have occurred during the process of inflammation, leading to the dissolution of calcified deposits.
Publisher: John Libbey Eurotext
Date: 09-2015
Publisher: Wiley
Date: 12-10-2015
Publisher: Elsevier BV
Date: 2023
DOI: 10.1016/J.JACI.2022.09.011
Abstract: Mast cells (MCs) are tissue-resident cells with various immunological functions. MCs are increased in atopic dermatitis (AD) skin and can contribute to the inflammation. Although skin MCs are inducible from bone marrow (BM) cells in vitro, they are maintained locally by self-proliferation in the steady state in vivo. However, how skin MCs are increased in AD skin, including the infiltration of BM-derived MC progenitors (MCps) and their differentiation, remains unclear. We aimed to identify and characterize BM-derived MCps in AD skin. BM-derived MCps in AD skin were analyzed by flow cytometry using BM-chimeric mice and parabiosis in an MC903-induced AD model. BM-derived MCps in AD-like skin were compared with resident MCs for gene expression by RNA sequence analysis. We observed local proliferation of resident MCs and an increase in BM-derived MCs in AD-like skin. BM-derived MCs in the skin were derived from circulating MCps and were distinguishable from resident MCs by integrinβ7. RNA sequence analysis showed that integrinβ7 BM-derived integrinβ7
Publisher: John Libbey Eurotext
Date: 07-2017
Publisher: John Libbey Eurotext
Date: 07-2016
Publisher: Frontiers Media SA
Date: 12-05-2022
DOI: 10.3389/FIMMU.2022.898419
Abstract: Skin is a frontline organ that is continuously exposed to external stimuli, including pathogens. Various immune cells reside in the skin under physiological conditions and protect the body from the entry of pathogens/antigens by interacting with each other and orchestrating erse cutaneous immune responses. To avoid unnecessary inflammation and tissue damage during the elimination of external pathogens and antigens, skin possesses regulatory systems that fine-tune these immune reactions. Mast cells (MCs) are one of the skin-resident immune cell populations that play both effector and regulatory functions in the cutaneous immune response. So far, the interleukin-10-mediated mechanisms have mostly been investigated as the regulatory mechanisms of MCs. Recent studies have elucidated other regulatory mechanisms of MCs, such as the maintenance of regulatory T/B cells and the programmed cell death protein-1 rogrammed cell death-ligand 1-mediated inhibitory pathway. These regulatory pathways of MCs have been suggested to play important roles in limiting the excessive inflammation in inflammatory skin diseases, such as contact and atopic dermatitis. The regulatory functions of MCs may also be involved in the escape mechanisms of antitumor responses in skin cancers, such as melanoma. Understanding and controlling the regulatory functions of skin MCs may lead to novel therapeutic strategies for inflammatory skin diseases and skin cancers.
Publisher: Wiley
Date: 04-11-2015
DOI: 10.1111/JDV.13494
Publisher: Wiley
Date: 15-06-2022
DOI: 10.1002/SKI2.124
No related grants have been discovered for Yuki Keith.