ORCID Profile
0000-0001-7049-6900
Current Organisation
Centre National de la Recherche Scientifique
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Publisher: Springer Science and Business Media LLC
Date: 04-2021
Publisher: Springer Science and Business Media LLC
Date: 14-09-2016
DOI: 10.1038/NATURE19356
Publisher: Springer Science and Business Media LLC
Date: 2013
Publisher: Springer Science and Business Media LLC
Date: 27-07-2015
DOI: 10.1038/NG.3360
Publisher: American Geophysical Union (AGU)
Date: 04-2017
DOI: 10.1002/2017GC006854
Publisher: Springer Science and Business Media LLC
Date: 03-02-2020
Publisher: Public Library of Science (PLoS)
Date: 28-12-2020
DOI: 10.1371/JOURNAL.PGEN.1009190
Abstract: The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A total of 200 genes were found to significantly affect BMD. This pool of BMD genes comprised 141 genes with previously unknown functions in bone biology and was complementary to pools derived from recent human studies. Nineteen of the 141 genes also caused skeletal abnormalities. Examination of the BMD genes in osteoclasts and osteoblasts underscored BMD pathways, including vesicle transport, in these cells and together with in silico bone turnover studies resulted in the prioritization of candidate genes for further investigation. Overall, the results add novel pathophysiological and molecular insight into bone health and disease.
No related grants have been discovered for Yann Herault.