ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0003-1701-9480

Current Organisations
Beatson Institute for Cancer Research , University of Glasgow

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Publications

Publication

MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

Publisher: Elsevier BV

Date: 04-2014

DOI: 10.1016/J.CCR.2014.03.006

Publication

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

Publisher: eLife Sciences Publications, Ltd

Date: 07-06-2021

DOI: 10.7554/ELIFE.63807

Abstract: RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine and the mechanisms of how they contribute to tumourigenesis remain unclear. Here, we show that RAL GTPases are necessary and sufficient to activate EGFR/MAPK signalling in the intestine, via induction of EGFR internalisation. Knocking down Drosophila RalA from intestinal stem and progenitor cells leads to increased levels of plasma membrane-associated EGFR and decreased MAPK pathway activation. Importantly, in addition to influencing stem cell proliferation during damage-induced intestinal regeneration, this role of RAL GTPases impacts on EGFR-dependent tumourigenic growth in the intestine and in human mammary epithelium. However, the effect of oncogenic RAS in the intestine is independent from RAL function. Altogether, our results reveal previously unrecognised cellular and molecular contexts where RAL GTPases become essential mediators of adult tissue homeostasis and malignant transformation.

Publication

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

Publisher: Elsevier BV

Date: 06-2013

DOI: 10.1016/J.STEM.2013.04.006

Publication

Author response: RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

Publisher: eLife Sciences Publications, Ltd

Date: 24-05-2021

DOI: 10.7554/ELIFE.63807.SA2

Related Organisations

Organisation

Washington University In Saint Louis School Of Medicine

Location: United States of America

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Organisation

Beatson Institute For Cancer Research

Location: United Kingdom of Great Britain and Northern Ireland

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Organisation

Mount Sinai Hospital

Location: United States of America

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Organisation

University Of Glasgow

Location: United Kingdom of Great Britain and Northern Ireland

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Organisation

University Of Glasgow

Location: No location found

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Related Funding Activities

No related grants have been discovered for Julia Cordero.

Julia Cordero

Researcher

Related Links

Publications

MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

Author response: RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

Related Organisations

Washington University In Saint Louis School Of Medicine

Beatson Institute For Cancer Research

Mount Sinai Hospital

University Of Glasgow

University Of Glasgow

Related Funding Activities

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