ORCID Profile
0000-0001-9223-3896
Current Organisation
University of Southampton
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Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6SM90091G
Abstract: Correction for 'Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMR' by Francesca Piana et al., Soft Matter, 2016, 12, 4034-4043.
Publisher: Wiley
Date: 08-01-2018
DOI: 10.1002/NBM.3870
Abstract: Fumarate is an important probe of metabolism in hyperpolarized magnetic resonance imaging and spectroscopy. It is used to detect the release of fumarase in cancer tissues, which is associated with necrosis and drug treatment. Nevertheless, there are limited reports describing the detailed kinetic studies of this enzyme in various cells and tissues. Thus, we aimed to evaluate the sub-minute kinetics of human red blood cell fumarase using nuclear magnetic resonance (NMR) spectroscopy, and to provide a quantitative description of the enzyme that is relevant to the use of fumarate as a probe of cell rupture. The fumarase reaction was studied using time courses of
Publisher: Royal Society of Chemistry
Date: 2020
Publisher: Frontiers Media SA
Date: 25-05-2018
Publisher: Royal Society of Chemistry
Date: 2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6SM00607H
Abstract: Eighteen N-aryl-N'-alkyl urea gelators were synthesised in order to understand the effect of head substituents on gelation performance. Minimum gelation concentration values obtained from gel formation studies were used to rank the compounds and revealed the remarkable performance of 4-methoxyphenyl urea gelator 15 in comparison to 4-nitrophenyl analogue 14, which could not be simply ascribed to substituent effects on the hydrogen bonding capabilities of the urea protons. Crystal structure prediction calculations indicated alternative low energy hydrogen bonding arrangements between the nitro group and urea protons in gelator 14, which were supported experimentally by NMR spectroscopy. As a consequence, it was possible to relate the observed differences to interference of the head substituents with the urea tape motif, disrupting the order of supramolecular packing. The combination of unbiased structure prediction calculations with NMR is proposed as a powerful approach to investigate the supramolecular arrangement in gel fibres and help understand the relationships between molecular structure and gel formation.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CP00145F
Abstract: Long-lived singlet order is exploited in diffusion NMR experiments to successfully measure the tortuosity of randomly packed spheres with diameters ranging from 500 to 1000 μm.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4RA15241G
Abstract: The addition of a certain amount of organophosphorus chemical warfare agent simulant DMMP promotes strengthening of the urea-based supramolecular gel structure.
Location: United Kingdom of Great Britain and Northern Ireland
Location: Italy
No related grants have been discovered for Giuseppe Pileio.