ORCID Profile
0000-0001-6062-7823
Current Organisations
University of Coimbra
,
University of Cambridge
,
Nanyang Technological University
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Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CS00084K
Abstract: Functional printing of graphene and related two-dimensional materials provides an ideal platform for next generation disruptive technologies and applications.
Publisher: Wiley
Date: 04-12-2021
Abstract: Flexographic printing is promising for large‐area electronics due to high print‐speed and roll‐to‐roll capability. There have been recent attempts in using graphene as an active pigment in inks, most notably for slower techniques such as inkjet and screen printing. However, formulation of graphene‐enhanced inks for high‐speed printing and its effect on key metrics have never been investigated. Herein, graphene nanoplatelets (GPs) are incorporated to a conductive flexographic ink without compromising the rheological properties. An industrial scale at 100 m min −1 is printed on paper and polyethylene terephthalate (PET) substrates using a commercial flexographic press, and statistical performance variations are investigated across entire print runs. It is shown that GP‐incorporation improves sheet‐resistance ( R s ) and uniformity, with up to 54% improvement in average R s and 45% improvement in the standard‐deviation on PET. The adhesion on both the substrates improves with GP‐incorporation, as verified by tape/crosshatch tests. The durability of GP‐enhanced s les is probed with a 1000 cyclic bend‐test, with 0.31% average variation in resistance in the flat state on PET between the first and last 100 bends, exhibiting a robust print. The statistically scalable results show that GP‐incorporation offers a cost‐performance advantage for flexographic printing of large‐area conductive patterns without modifications to traditional high‐speed graphics printing presses.
Publisher: Wiley
Date: 02-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5CP05924K
Abstract: Using a multidisciplinary approach combining computational modeling, biophysical characterization, and in vitro toxicity studies, the anti-amyloid effect of graphene oxide and its molecular mechanism is investigated.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 14-08-2020
Abstract: A binary solvent ink exploiting solutal Marangoni flows to suppress the coffee-ring effect for uniform printing of 2D crystals.
Publisher: American Chemical Society (ACS)
Date: 23-12-2016
DOI: 10.1021/ACS.BIOMAC.5B01469
Abstract: Hydrogen sulfide (H2S) is involved in a myriad of cell signaling processes that trigger physiological events ranging from vasodilation to cell proliferation. Moreover, disturbances to H2S signaling have been associated with numerous pathologies. As such, the ability to release H2S in a cellular environment and stimulate signaling events is of considerable interest. Herein we report the synthesis of macromolecular H2S donors capable of stimulating cell signaling pathways in both the cytosol and at the cell membrane. Specifically, copolymers having pendent oligo(ethylene glycol) and benzonitrile groups were synthesized, and the benzonitrile groups were subsequently transformed into primary aryl thioamide groups via thionation using sodium hydrosulfide. These thioamide moieties could be incorporated into a hydrophilic copolymer or a block copolymer (i.e., into either the hydrophilic or hydrophobic domain). An electrochemical sensor was used to demonstrate release of H2S under simulated physiological conditions. Subsequent treatment of HEK293 cells with a macromolecular H2S donor elicited a slow and sustained increase in cytosolic ERK signaling, as monitored using a FRET-based biosensor. The macromolecular donor was also shown to induce a small, fast and sustained increase in plasma membrane-localized PKC activity immediately following addition to cells. Studies using an H2S-selective fluorescent probe in live cells confirmed release of H2S from the macromolecular donor over physiologically relevant time scales consistent with the signaling observations. Taken together, these results demonstrate that by using macromolecular H2S donors it is possible to trigger spatiotemporally confined cell signaling events. Moreover, the localized nature of the observed signaling suggests that macromolecular donor design may provide an approach for selectively stimulating certain cellular biochemical pathways.
Publisher: Wiley
Date: 10-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6PY00639F
Abstract: This review highlights the substantial progress in the syntheses and applications of filomicelles, an emerging nanomaterial with distinct and useful properties.
Publisher: Wiley
Date: 26-02-2022
Abstract: Non‐fullerene acceptors (NFAs) have recently breathed new life into organic photovoltaic (OPVs), achieving breakthrough photovoltaic conversion efficiencies. Unlike conventional fullerene acceptors, they offer strong levels of tunability and solution‐processibility that allow them to be easily exploited in the roll‐to‐roll (R2R) fabrication process. This has enabled a new renaissance for OPVs in the face of other photovoltaic material candidates for large‐scale, high‐throughput, cost‐effective manufacturing. In this review, the current progress of R2R manufacturing of NFA‐OPVs and the applications enabled by them are summarized. The perspectives on their research, technological, and future prospects for industry scale‐up are also presented.
Publisher: Wiley
Date: 19-04-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6PY01797E
Abstract: Polymerization-induced self-assembly (PISA) is an easily applied synthetic technique for the preparation of polymer nanoparticles with various shapes and at high concentrations.
Publisher: Wiley
Date: 30-03-2023
Abstract: Multienergy X‐ray detection is critical to effectively differentiate materials in a variety of diagnostic radiology and nondestructive testing applications. Silicon and selenium X‐ray detectors are the most common for multienergy detection however, these present poor energy discrimination across the broad X‐ray spectrum and exhibit limited spatial resolution due to the high thicknesses required for radiation attenuation. Here, an X‐ray detector based on solution‐processed thin‐film metal halide perovskite that overcomes these challenges is introduced. By harnessing an optimized n‐i‐p diode configuration, operation is achieved across a broad range of soft and hard X‐ray energies stemming from 0.1 to 10's of keV. Through detailed experimental and simulation work, it is shown that optimized Cs 0.1 FA 0.9 PbI 3 perovskites effectively attenuate soft and hard X‐rays, while also possessing excellent electrical properties to result in X‐ray detectors with high sensitivity factors that exceed 5 × 10 3 and 6 × 10 4 µC Gy −1 cm −2 within soft and hard X‐ray regimes, respectively. Harnessing the solution‐processable nature of the perovskites, roll‐to‐roll printable X‐ray detectors on flexible substrates are also demonstrated.
Publisher: Palgrave Macmillan UK
Date: 2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5PY01467K
Abstract: RAFT-mediated emulsion polymerization of styrene and subsequent morphological transition produces nanoaggregates with tuneable morphologies.
Publisher: Wiley
Date: 08-07-2019
Publisher: American Chemical Society (ACS)
Date: 15-07-2016
DOI: 10.1021/ACS.BIOMAC.6B00919
Abstract: Oxytocin, a cyclic nine amino acid neurohypophyseal hormone therapeutic, is effectively used in the control of postpartum hemorrhaging (PPH) and is on the WHO List of Essential Medicines. However, oxytocin has limited shelf life stability in aqueous solutions, particularly at temperatures in excess of 25 °C and injectable aqueous oxytocin formulations require refrigeration (<8 °C). This is particularly problematic in the hot climates often found in many developing countries where daytime temperatures can exceed 40 °C and where reliable cold-chain storage is not always achievable. The purpose of this study was to develop N-terminal amine targeted PEGylation strategies utilizing both linear PEG and polyPEG "comb" polymers as an effective method for stabilizing solution formulations of this peptide for prolonged storage in the absence of efficient cold-chain storage. The conjugation chemistries investigated herein include irreversible amine targeted conjugation methods utilizing NHS ester and aldehyde reductive amination chemistry. Additionally, one reversible conjugation method using a Schiff base approach was explored to allow for the release of the native peptide, thus, ensuring that biological activity remains unaffected. The reversibility of this approach was investigated for the different polymer architectures, alongside a nonpolymer oxytocin analogue to monitor how pH can tune native peptide release. Elevated temperature degradation studies of the polymer conjugates were evaluated to assess the stability of the PEGylated analogues in comparison to the native peptide in aqueous formulations to mimic storage conditions in developing nations and regions where storage under appropriate conditions is challenging.
Location: Australia
Location: United Kingdom of Great Britain and Northern Ireland
Location: No location found
Start Date: 2019
End Date: End date not available
Funder: Royal Academy of Engineering
View Funded ActivityStart Date: 2018
End Date: 2019
Funder: Engineering and Physical Sciences Research Council
View Funded Activity