ORCID Profile
0000-0002-5569-3970
Current Organisations
National Ageing Research Institute
,
Macquarie University
,
University of Brasilia
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Publisher: Elsevier BV
Date: 05-2021
Publisher: Elsevier BV
Date: 12-2020
Publisher: Wiley
Date: 08-02-2021
DOI: 10.1002/GPS.5502
Abstract: Internet‐based interventions involving elements of cognitive behavior therapy, psychoeducation, relaxation and skills training for caregivers of people with dementia have been found to be promising in Western countries. Given these outcomes, the adapted version of a multi‐component online caregiver skills training and support program of the World Health Organization, called iSupport, was tested for feasibility and preliminary effectiveness in India. One hundred fifty‐one caregivers of family members with a diagnosis of Alzheimer's disease or dementia were randomized to either the intervention arm (iSupport n = 74) or to the control group (an education‐only e‐book program n = 77). Participants were assessed using self‐rated measures of depression and perceived burden, which were the primary outcome measures, at baseline and 3‐month follow‐up. Person‐centered attitude, self‐efficacy, mastery and self‐rated health were also assessed. Fifty‐five caregivers (29 in the iSupport group and 26 in the control condition) completed the study. The recruitment and retention rate of the study were 44.67% and 36.42% respectively. No significant differences were found between the two groups at 3‐month follow‐up on the primary outcomes. Among the secondary outcomes, significant improvement was only seen in caregivers' person‐centered attitude towards persons with dementia in the iSupport group ( t = 2.228 p 0.05). Despite efforts to recruit and retain participants to the online program, this study had a low recruitment and retention rate, which require closer attention and indicates a need for further adaptations of the Indian version of the iSupport program to improve its acceptability and accessibility. The lessons learned from this study will guide the further development of caregiver training and support interventions in India. The trial was registered with the Clinical Trials Registry‐India (Trial Registration No. CTRI/2017/02/007876).
Publisher: Elsevier BV
Date: 06-2017
Publisher: Medknow
Date: 2023
Publisher: SAGE Publications
Date: 2013
Publisher: JMIR Publications Inc.
Date: 04-04-2022
Abstract: ndia is undergoing a demographic transition characterized by population aging and is witnessing a high dementia rate. Although nearly 7 million people live with dementia in India, dementia awareness is poor, and current resources addressing dementia care are basic and often incomplete, duplicated, or conflicting. To address this gap, this study aims to use digital media, which has had a massive technological uptake in India, to improve dementia care in India. he objective of this paper is to describe an intervention study design that examines the feasibility and acceptability of Moving Pictures India, a digital media resource to improve dementia care in India. his study employs a mixed methods design and is ided into 4 phases: (1) video interviews with Indian caregivers and health professionals (2) coproduction of resources (3) pilot randomized controlled trial (RCT) and (4) dissemination and analytics. The pilot RCT will follow an experimental parallel group design with 2 arms aiming to assess the impact, feasibility, and acceptability of the developed resources. The primary outcome measures for the pilot RCT will be feasibility and acceptability, while the secondary outcome measures will be caregiver burden, mood, and quality of life. his study received funding from the Alzheimer’s Association in the United States in July 2021. In 2023, we will enroll 60 dementia caregivers (40 caregivers in the intervention arm and 20 in the control) for the pilot RCT. The study has been approved by the National Institute of Mental Health and Neuro Sciences Ethics Committee (26th IEC (BEH.SC.DIV.)/2020-21 dated November 11, 2020) the Health Ministry's Screening Committee, India (proposal ID 2020-10137) the Curtin University Human Research Ethics Committee (approval number HRE2020-0735) and the NARI Research Governance Office (site-specific approval dated March 17, 2021). his protocol is designed to deliver unique, coproduced, and evidence-based media resources to support caregivers of persons with dementia in India and other countries aiming to utilize digital media for dementia care. If the intervention is found feasible and acceptable, postpiloting analytics and qualitative feedback will be used to develop an implementation trial to evaluate the effectiveness of the potential low-risk high-benefit intervention in practice. linical Trials Registry-India CTRI/2021/01/030403 ctri.nic.in/Clinicaltrials maindet2.php?trialid=50794 ERR1-10.2196/38456
Publisher: Elsevier BV
Date: 09-2020
Publisher: Springer Science and Business Media LLC
Date: 08-05-2018
Publisher: Elsevier BV
Date: 05-2022
DOI: 10.1016/J.PHARMTHERA.2021.108021
Abstract: Among the various biological properties presented by Mesenchymal Stem Cells (MSCs), their ability to control the immune response and fight pathogen infection through the production of antimicrobial peptides (AMPs) have been the subject of intense research in recent years. AMPs secreted by MSCs exhibit activity against a wide range of microorganisms, including bacteria, fungi, yeasts, and viruses. The main AMPs produced by these cells are hepcidin, cathelicidin LL-37, and β-defensin-2. In addition to acting against pathogens, those AMPs have also been shown to interact with MSCs to modulate MSC proliferation, migration, and regeneration, indicating that such peptides exert a more erse biological effect than initially thought. In the present review, we discuss the production of AMPs by MSCs, revise the multiple functions of these peptides, including their influence over MSCs, and present an overview of clinical situations in which the antimicrobial properties of MSCs may be explored for therapy. Finally, we discuss possibilities of combining MSCs and AMPs to generate improved therapeutic strategies.
Publisher: JMIR Publications Inc.
Date: 02-06-2022
DOI: 10.2196/38456
Abstract: India is undergoing a demographic transition characterized by population aging and is witnessing a high dementia rate. Although nearly 7 million people live with dementia in India, dementia awareness is poor, and current resources addressing dementia care are basic and often incomplete, duplicated, or conflicting. To address this gap, this study aims to use digital media, which has had a massive technological uptake in India, to improve dementia care in India. The objective of this paper is to describe an intervention study design that examines the feasibility and acceptability of Moving Pictures India, a digital media resource to improve dementia care in India. This study employs a mixed methods design and is ided into 4 phases: (1) video interviews with Indian caregivers and health professionals (2) coproduction of resources (3) pilot randomized controlled trial (RCT) and (4) dissemination and analytics. The pilot RCT will follow an experimental parallel group design with 2 arms aiming to assess the impact, feasibility, and acceptability of the developed resources. The primary outcome measures for the pilot RCT will be feasibility and acceptability, while the secondary outcome measures will be caregiver burden, mood, and quality of life. This study received funding from the Alzheimer’s Association in the United States in July 2021. In 2023, we will enroll 60 dementia caregivers (40 caregivers in the intervention arm and 20 in the control) for the pilot RCT. The study has been approved by the National Institute of Mental Health and Neuro Sciences Ethics Committee (26th IEC (BEH.SC.DIV.)/2020-21 dated November 11, 2020) the Health Ministry's Screening Committee, India (proposal ID 2020-10137) the Curtin University Human Research Ethics Committee (approval number HRE2020-0735) and the NARI Research Governance Office (site-specific approval dated March 17, 2021). This protocol is designed to deliver unique, coproduced, and evidence-based media resources to support caregivers of persons with dementia in India and other countries aiming to utilize digital media for dementia care. If the intervention is found feasible and acceptable, postpiloting analytics and qualitative feedback will be used to develop an implementation trial to evaluate the effectiveness of the potential low-risk high-benefit intervention in practice. Clinical Trials Registry-India CTRI/2021/01/030403 ctri.nic.in/Clinicaltrials maindet2.php?trialid=50794 DERR1-10.2196/38456
Publisher: Springer Singapore
Date: 2021
Publisher: Informa UK Limited
Date: 21-02-2020
Publisher: Elsevier BV
Date: 2019
DOI: 10.1016/J.AJP.2018.11.015
Abstract: We sought to examine the endophenotype pattern of neuro-hemodynamic substrates of emotion counting Stroop (ecStroop) paradigm in patients with OCD, their unaffected siblings [first degree relatives-FDR] and healthy controls (HC). OCD patients (medication naïve)[N = 16], their unaffected siblings(FDR)[N = 16] and HC [N = 24] were compared using an established ecStroop paradigm in a 3-Tesla fMRI. The relative BOLD signals corresponding to the three types of conditions (neural words-N, words with negative emotional salience-E and words with salience for OCD-O) were examined in the apriori hypothesized brain regions. Both in O minus N contrast and O minus E contrast, the groups demonstrated significant differential activation of right insula (BA 13). The post-hoc analyses showed in patients and FDRs relative to HC the following: significant hyperactivation of insula in O minus E contrast significant hyperactivation of right insula and right DLPFC (BA 9) in O minus N contrast. The neuro-hemodynamic responses corresponding to the obsessive words in insula and DLPFC could be potential endophenotypes. "Threat relatedness" might thus have a vulnerability meaning in the pathogenesis and neurobiological basis of OCD.
Publisher: Elsevier BV
Date: 05-2016
Publisher: Elsevier BV
Date: 05-2018
Publisher: Elsevier BV
Date: 10-2014
DOI: 10.1016/J.COMPPSYCH.2014.07.006
Abstract: Obsessive-compulsive disorder (OCD) is a heterogeneous condition with evidence of familiality in a considerable proportion of patients. A classification into familial and sporadic forms has been proposed to explain the heterogeneity. The current study aims to compare the demographic, clinical and comorbidity patterns of patients with and without a family history of OCD in first-degree relatives. 802 consecutive patients who consulted a specialty OCD Clinic at a tertiary care psychiatric hospital in India were evaluated with the Mini-International Neuropsychiatric Interview, the Yale-Brown Obsessive-Compulsive Scale, and the Clinical Global Impression Scale. Family history was assessed by interviewing patients and at least one first-degree relative. Family history of OCD was seen in 152 patients (19%). Family history was associated with juvenile onset (Χ(2)=19.472, p<0.001), obsessions of contamination (Χ(2)=6.658, p=0.01), hoarding (Χ(2)=4.062, p=0.032), need for symmetry (Χ(2)=3.95, p=0.047), washing compulsion (Χ(2)=7.923, p=0.005), ordering compulsions (Χ(2)=6.808, p=0.009), repeating compulsions (Χ(2)=4.950, p=0.026) and compulsions by proxy (Χ(2)=7.963, p=0.005). Family history was also associated with greater severity of OCD (t=-2.31, p=0.022) and compulsions (t=-3.09, p=0.002) and longer duration of illness at presentation (t=-2.93, p=0.004). Our findings suggest that familial OCD may have distinctive clinical features. Studying familial forms of OCD may offer unique insight in to understanding the genetic basis of OCD.
Publisher: Elsevier BV
Date: 2018
DOI: 10.1016/J.JAD.2017.08.014
Abstract: Cognitive behaviour therapy (CBT) for Obsessive Compulsive Disorder (OCD) is therapist-intensive and prolonged making it less accessible to patients, particularly in resource-constrained situations. We examined the efficacy of a brief psychotherapeutic intervention as an adjunct to serotonin reuptake inhibitors (SRIs) in OCD. We randomized 64 adult OCD patients stabilized on SRIs to either the 6-session brief family-based intervention (BFBI n = 30) that included psychoeducation, exposure and response prevention and family intervention or to a control arm of relaxation exercises (RE). Assessments were conducted at baseline and at 1- and 3- months post-intervention. Primary outcome measure was response to treatment defined as ≥ 35% reduction in the Yale-Brown Obsessive Compulsive Scale total score relative to baseline score plus a Clinical Global Impression- Improvement rating of very much improved or much improved. Family accommodation and expressed emotions were also assessed. At 3- month follow-up, the BFBI group responded better than the RE group (53% vs. 12%, p < 0.001). Illness severity, family accommodation and expressed emotion declined significantly over time in the BFBI group compared to the RE group. The BFBI (OR = 13.17, p < 0.001) and baseline illness severity (OR = 0.746, p < 0.011) predicted treatment response. S le size was small and follow-up duration was short. Control group had less time with the therapist although number of sessions was identical in both the groups. Briefer intervention is effective in treating OCD. Briefer and inclusive format of intervention has important implications for clinical practice in resource-constrained circumstances.
Publisher: Oxford University Press (OUP)
Date: 02-2018
Publisher: Elsevier BV
Date: 11-2011
Publisher: Wiley
Date: 09-09-2019
DOI: 10.1002/WPS.20684
Publisher: Elsevier BV
Date: 04-2020
Publisher: Elsevier BV
Date: 09-2013
Location: India
Location: No location found
No related grants have been discovered for Upasana Baruah.