ORCID Profile
0000-0002-1801-5548
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Information Systems | Other Artificial Intelligence | Information Systems Development Methodologies | Conceptual Modelling |
Public services management | Information processing services | Community services not elsewhere classified
Publisher: Inderscience Publishers
Date: 2007
Publisher: Wiley
Date: 14-03-2020
DOI: 10.1111/NPH.16480
Publisher: Wiley
Date: 15-02-2021
DOI: 10.1111/PCE.14017
Publisher: Elsevier BV
Date: 04-2014
DOI: 10.1016/J.BIOMATERIALS.2014.01.081
Abstract: Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Identification of culture conditions enabling prolonged expansion and rejuvenation would have dramatic impact in regenerative medicine. aMSC-derived decellularized extracellular matrix (ECM) has been shown to provide such microenvironment which promotes MSC self renewal and "stemness". Since previous studies have demonstrated superior proliferation and osteogenic potential of human fetal MSCs (fMSCs), we hypothesize that their ECM may promote expansion of clinically relevant aMSCs. We demonstrated that aMSCs were more proliferative (∼ 1.6 ×) on fMSC-derived ECM than aMSC-derived ECMs and traditional tissue culture wares (TCPS). These aMSCs were smaller and more uniform in size (median ± interquartile range: 15.5 ± 4.1 μm versus 17.2 ± 5.0 μm and 15.5 ± 4.1 μm for aMSC ECM and TCPS respectively), exhibited the necessary biomarker signatures, and stained positive for osteogenic, adipogenic and chondrogenic expressions indications that they maintained multipotency during culture. Furthermore, fMSC ECM improved the proliferation (∼ 2.2 ×), size (19.6 ± 11.9 μm vs 30.2 ± 14.5 μm) and differentiation potential in late-passaged aMSCs compared to TCPS. In conclusion, we have established fMSC ECM as a promising cell culture platform for ex vivo expansion of aMSCs.
Publisher: University of Wollongong, SMART Infrastructure Facility
Date: 2014
Publisher: DE GRUYTER
Date: 2015
Publisher: University of Tartu
Date: 31-12-2001
DOI: 10.12697/SSS.2001.29.2.10
Abstract: The workpractices associaied with the use of an information system can be described using semiotic theories in terms of patterns of human communication. A model of workpractices has been created called the systemic semiotic workpractice framework that employs two compatible but distinct semiotic theories in order to explain the complexity of information systems use in organisational contexts. One of these theories called social semiotics can be used to describe atypical workpractice realisations, where a user renegotiates one or more canonical sequences of activities typically associated with a specific system feature. In doing so the user may alter the staging of the workpractice, redefine the goal of the workpractice, or renegotiate the usual role they adopt within the workpractice. Central concepts in social semiotics are explained and applied to an actual atypical renegotiated workpractice associated with the loan of materials to students in a smalloperational level information system called ALABS.
Publisher: MDPI AG
Date: 10-02-2021
Abstract: Historically, countries such as Australia, Canada and New Zealand have witnessed an increased over-representation of minority groups who are exposed to the criminal justice system. For many years in Australia, young First Nations males have been over-represented in the juvenile justice system in all states and territories. Many of these young males have disengaged from their schooling early, some through deliberate exclusion from the education system and others by choice. However, the choices for many young First Nations males may not be as clear cut as first might seem. This paper shows that over-representation in the juvenile justice system may be as a direct result of racial profiling, surveillance and over-policing of First Nations peoples within Australia. The literature addresses the ways in which young First Nations males experience these phenomena from an early age, and the long-term effects and consequences that can arise from these occurrences. An analysis of the current research both internationally and within Australia is thus conducted.
Publisher: Elsevier BV
Date: 2010
Publisher: Springer Science and Business Media LLC
Date: 12-2013
DOI: 10.1186/SCRT372
Publisher: Informa UK Limited
Date: 05-2013
Publisher: Emerald
Date: 19-07-2022
Abstract: The purpose of this paper is to demonstrate the utility of systemic functional linguistics (SFL) as an underlying model to examine the similarities/differences between spoken and written peer-to-peer (P2P) communication. An embedded mixed methods experimental design with linguistically standardized experimental stimuli was used to expose the basic linguistic differences between P2P communications that can be attributed to communication medium (spoken/written) and product type (hedonic/utilitarian). The findings show, empirically, that consumer’s spoken language is not linguistically equivalent to that of written language. This confirms that the capability of language to convey semantic meaning in spoken communication differs from written communication. This study extends the characteristics that differentiate hedonic from utilitarian products to include lexical density (i.e. hedonic) vs lexical sparsity (i.e. utilitarian). The findings of this study are not wholly relevant to other forms of consumer communication (e.g. viral marketing). This research used a few SFL resources. This research shows that marketers should ideally apply a semantic approach to the analysis of communications, given that communication meaning can vary across channels. Marketers may also want to focus on specific feedback channels (e.g. review site vs telephone) depending on the depth of product’s details that need to be captured. This study also offers metrics that advertisers could use to classify media and to characterize consumer segments. This research shows the relevance of SFL for understanding P2P communications and has potential applications to other marketing communications.
Publisher: Wiley
Date: 29-11-2021
DOI: 10.1002/PPP3.10169
Abstract: Oil palm is the first oil‐producing crop globally, representing nearly 20 million ha. In the recent past, oil palm cultivation has been controversial not only because of land utilisation at the expense of primary tropical forests or health concerns associated with palm oil, but also pollution caused by fertilization (including CO 2 produced to synthesise fertilizers). Oil palm fields are heavily fertilized with potassium (K), and thus finding better, more parsimonious methods to monitor K nutrition is more important than ever. Here, we suggest that metabolomics and subsequent machine learning of metabolic signatures represent a promising tool to probe K requirements, opening avenues for precision agriculture in oil palm industry.
Publisher: Elsevier BV
Date: 08-1997
Publisher: SAGE Publications
Date: 12-05-2014
Abstract: Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors remain incurable. Metastatic disease progression continues to be poorly understood due to the lack of appropriate model systems. To address this gap in understanding, we propose an all-human microphysiological system that facilitates the investigation of cancer behavior in the liver metastatic niche . This existing LiverChip is a 3D-system modeling the hepatic niche it incorporates a full complement of human parenchymal and non-parenchymal cells and effectively recapitulates micrometastases. Moreover, this system allows real-time monitoring of micrometastasis and assessment of human-specific signaling. It is being utilized to further our understanding of the efficacy of chemotherapeutics by examining the activity of established and novel agents on micrometastases under conditions replicating diurnal variations in hormones, nutrients and mild inflammatory states using programmable microdispensers. These inputs affect the cues that govern tumor cell responses. Three critical signaling groups are targeted: the glucose/insulin responses, the stress hormone cortisol and the gut microbiome in relation to inflammatory cues. Currently, the system sustains functioning hepatocytes for a minimum of 15 days confirmed by monitoring hepatic function (urea, α-1-antitrypsin, fibrinogen, and cytochrome P450) and injury (AST and ALT). Breast cancer cell lines effectively integrate into the hepatic niche without detectable disruption to tissue, and preliminary evidence suggests growth attenuation amongst a subpopulation of breast cancer cells. xMAP technology combined with systems biology modeling are also employed to evaluate cellular crosstalk and illustrate communication networks in the early microenvironment of micrometastases. This model is anticipated to identify new therapeutic strategies for metastasis by elucidating the paracrine effects between the hepatic and metastatic cells, while concurrently evaluating agent efficacy for metastasis, metabolism and tolerability.
Publisher: Springer International Publishing
Date: 2017
Publisher: Springer Berlin Heidelberg
Date: 2015
Publisher: Cogitatio
Date: 20-06-2023
Abstract: This thematic issue addresses the challenges faced by Indigenous peoples in protecting their rights and maintaining their unique cultures and ways of life. Despite residing on all continents and possessing distinct social, cultural, economic, and political characteristics, Indigenous peoples have historically faced oppression and violation of their rights. Measures to protect Indigenous rights are gradually being recognized by the international community, but ongoing issues such as illegal deforestation, mining, and land clearances continue to desecrate sacred sites and oppress Indigenous peoples. Indigenous women and youth are particularly vulnerable, facing higher levels of gender‐based violence and overrepresentation in judicial sentencing statistics. Land rights continue to be threatened by natural resource extraction, infrastructure projects, large‐scale agricultural expansion, and conservation orders. There is also a heightened risk of statelessness for Indigenous peoples whose traditional lands cross national borders, leading to displacement, attacks, killings, and criminalization.
Publisher: Wiley
Date: 19-03-2019
DOI: 10.1111/NPH.15751
Abstract: Oil palm is by far the major oil‐producing crop on the global scale, with c . 62 Mt oil produced each year. This species is a strong potassium (K)‐demanding species cultivated in regions where soil K availability is generally low and waterlogging due to tropical heavy rains can limit further nutrient absorption. However, the metabolic effects of K and waterlogging have never been assessed precisely. Here, we examined the metabolic response of oil palm saplings in the glasshouse under controlled conditions (nutrient composition with low or high K availability, with or without waterlogging), using gas exchange, metabolomics and proteomics analyses. Our results showed that both low K and waterlogging have a detrimental effect on photosynthesis but stimulate leaf respiration, with differential accumulation of typical metabolic intermediates and enzymes of Krebs cycle and alternative catabolic pathways. In addition, we found a strong relationship between metabolic composition, the rate of leaf dark respiration, and cumulated respiratory loss. Advert environmental conditions (here, low K and waterlogging) therefore have an enormous effect on respiration in oil palm. Leaf metabolome and proteome appear to be good predictors of carbon balance, and open avenues for cultivation biomonitoring using functional genomics technologies.
Publisher: Springer International Publishing
Date: 2013
Publisher: IEEE
Date: 09-2015
Publisher: IGI Global
Date: 2007
DOI: 10.4018/978-1-59904-063-9.CH009
Abstract: The authors demonstrate how Systemic Semiotics, an approach that combines a semiotic model of language called Systemic Functional Linguistics with selected concepts from Social Semiotics, can be applied to create Agent-Oriented Information Systems in which social processes can be elicited from stakeholders, specified by designers, and embedded into actual agent-based systems. The utility of Systemic Semiotics applied to Agent-Oriented Conceptual modelling is demonstrated by developing a real world system to address the problem of registering and training volunteers in an emergency service organisation. The experience of developing this system was then used to propose an experimental Agent-Oriented Conceptual Modelling Methodology that uses the same theory and concepts for describing the artefacts and the processes of agent-oriented systems development.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6LC01171C
Abstract: Microphysiological systems fitted with hydrogel scaffolds are critical tools in the assessment and development of therapeutic strategies to target dormant metastases.
Publisher: Elsevier BV
Date: 2019
Publisher: SAGE Publications
Date: 24-07-2016
Abstract: The liver is a highly metastasis-permissive organ, tumor seeding of which usually portends mortality. Its unique and erse architectural and cellular composition enable the liver to undertake numerous specialized functions, however, this distinctive biology, notably its hemodynamic features and unique microenvironment, renders the liver intrinsically hospitable to disseminated tumor cells. The particular focus for this perspective is the bidirectional interactions between the disseminated tumor cells and the unique resident cell populations of the liver notably, parenchymal hepatocytes and non-parenchymal liver sinusoidal endothelial, Kupffer, and hepatic stellate cells. Understanding the early steps in the metastatic seeding, including the decision to undergo dormancy versus outgrowth, has been difficult to study in 2D culture systems and animals due to numerous limitations. In response, tissue-engineered biomimetic systems have emerged. At the cutting-edge of these developments are ex vivo ‘microphysiological systems’ (MPS) which are cellular constructs designed to faithfully recapitulate the structure and function of a human organ or organ regions on a milli- to micro-scale level and can be made all human to maintain species-specific interactions. Hepatic MPSs are particularly attractive for studying metastases as in addition to the liver being a main site of metastatic seeding, it is also the principal site of drug metabolism and therapy-limiting toxicities. Thus, using these hepatic MPSs will enable not only an enhanced understanding of the fundamental aspects of metastasis but also allow for therapeutic agents to be fully studied for efficacy while also monitoring pharmacologic aspects and predicting toxicities. The review discusses some of the hepatic MPS models currently available and although only one MPS has been validated to relevantly modeling metastasis, it is anticipated that the adaptation of the other hepatic models to include tumors will not be long in coming.
Publisher: Informa UK Limited
Date: 06-2007
Publisher: Wiley
Date: 19-02-2020
DOI: 10.1111/PCE.13740
Publisher: Springer US
Date: 2002
Publisher: Elsevier BV
Date: 04-2018
Publisher: Wiley
Date: 28-11-2022
DOI: 10.1111/AJAG.13158
Abstract: This study explores older people's use of a free bus service in Wollongong, Australia. The research focus was on understanding the experiences of people over the age of 60 who use the service and the extent to which it contributes to their physical, mental and social well‐being. The ethnographic research utilised fieldwork and interviews for data collection. Participant observations took place on the bus, and interviews were undertaken at bus stops. Data were analysed using an inductive thematic approach. The research highlighted how bus services can be caring places for older people and a bus journey could be characterised as a therapeutic milieu. Travelling on the bus provided opportunities for health promotion due to active transport. Subsidised access to public transport supported people to maintain social connections throughout the city. Bus travel has contributed positively to the physical, mental and social well‐being of people over the age of 60 in Wollongong.
Publisher: Springer Berlin Heidelberg
Date: 2015
Publisher: MDPI
Date: 26-10-2018
Publisher: IGI Global
Date: 2019
Publisher: Springer International Publishing
Date: 2019
Publisher: Springer Science and Business Media LLC
Date: 14-10-2014
DOI: 10.1038/BJC.2014.533
Publisher: American Association for Cancer Research (AACR)
Date: 10-2006
DOI: 10.1158/0008-5472.CAN-06-0217
Abstract: The lymphotoxin-β receptor (LTβR) is a tumor necrosis factor receptor family member critical for the development and maintenance of various lymphoid microenvironments. Herein, we show that agonistic anti-LTβR monoclonal antibody (mAb) CBE11 inhibited tumor growth in xenograft models and potentiated tumor responses to chemotherapeutic agents. In a syngeneic colon carcinoma tumor model, treatment of the tumor-bearing mice with an agonistic antibody against murine LTβR caused increased lymphocyte infiltration and necrosis of the tumor. A pattern of differential gene expression predictive of cellular and xenograft response to LTβR activation was identified in a panel of colon carcinoma cell lines and when applied to a panel of clinical colorectal tumor s les indicated 35% likelihood a tumor response to CBE11. Consistent with this estimate, CBE11 decreased tumor size and/or improved long-term animal survival with two of six independent orthotopic xenografts prepared from surgical colorectal carcinoma s les. Targeting of LTβR with agonistic mAbs offers a novel approach to the treatment of colorectal and potentially other types of cancers. (Cancer Res 2006 66(19): 9617-24)
Publisher: Springer Science and Business Media LLC
Date: 14-08-2017
Publisher: Elsevier BV
Date: 07-2020
Publisher: Informa UK Limited
Date: 07-2013
Publisher: IEEE
Date: 12-2018
Publisher: Wiley
Date: 16-10-2016
DOI: 10.1111/PCE.12606
Publisher: Springer International Publishing
Date: 2021
Publisher: MDPI AG
Date: 13-06-2020
DOI: 10.3390/IJMS21124227
Abstract: Oil palm is an oil-producing crop of major importance at the global scale. Oil palm mesocarp lipids are used for myriads industrial applications, and market demand has been growing for decades. In addition, oil palm seeds are oleaginous, and the oil extracted therefrom can be used for several purposes, from food to cosmetics. As such, there is a huge need in oil palm seeds to maintain the global cohort of more than 2 billion trees. However, oil palm seed germination is a rather difficult process, not only to break dormancy, but also because it is long and often reaches lower-than-expected germination rates. Surprisingly, despite the crucial importance of germination for oil palm plantation management, our knowledge is still rather limited, in particular about germinating oil palm seed metabolism. The present review incorporates different pieces of information that have been obtained in the past few years, in oil palm and in other palm species, in order to provide an overview of germination metabolism and its control. Further insights can also be gained from other oleaginous model plants, such as Arabidopsis or canola, however, palm seeds have peculiarities that must be accounted for, to gain a better understanding of germinating seed metabolism.
Publisher: Springer US
Date: 2017
Publisher: IEEE
Date: 1998
Publisher: Wiley
Date: 17-01-2019
DOI: 10.1111/PCE.13450
Abstract: K deficiency and waterlogging are common stresses that can occur simultaneously and impact on crop development and yield. They are both known to affect catabolism, with rather opposite effects: inhibition of glycolysis and higher glycolytic fermentative flux, respectively. But surprisingly, the effect of their combination on plant metabolism has never been examined precisely. Here, we applied a combined treatment (K availability and waterlogging) to sunflower (Helianthus annuus L.) plants under controlled greenhouse conditions and performed elemental quantitation, metabolomics, and isotope analyses at different s ling times. Whereas separate K deficiency and waterlogging caused well-known effects such as polyamines production and sugar accumulation, respectively, waterlogging altered K-induced respiration enhancement (via the C
Publisher: Springer Science and Business Media LLC
Date: 13-06-2023
DOI: 10.1007/S44020-023-00036-4
Abstract: First Nations languages can play a significant role in ensuring connection to land, culture, Songlines, kinship, history, and stories. Ongoing language attrition for First Nations peoples of Australia has been due to colonization and past adverse government policies, which rendered First Nations languages a threat to the expansion of the colony. Through processes of dislocation from country and punishment for speaking language, many First Nations peoples began to lose their languages and were forcefully compelled to speak the English language on missions and reserves. Promoting First Nations languages in early educational contexts can instill a sense of cultural identity and connectedness to schooling for First Nations children, helping to ensure that languages are passed on to future generations. In many parts of Australia, First Nations languages are being revitalized and are being taught to both First Nations children and non-Indigenous children in early learning centers and in classrooms. This paper draws upon existing literature, briefly examining the removal of First Nations languages in Queensland from a historical perspective. The authors consider three essential elements required to work with First Nations communities when revitalizing First Nations languages and implementing a successful language program into schools: co-design, authentic delivery, and cultural inclusivity. We demonstrate how these elements have been used in the revitalization of First Nations languages in two Queensland schools. Finally, the importance of using an Indigenous centered approach to maintain languages at a local level is posited as a critical step in creating culturally inclusive environments for First Nations children in mainstream school settings.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4LC01416B
Abstract: Micromolded hydrogels lose non-fouling properties enabling cell adhesion and migration on the gel (left). We develop a method to regenerate the cell resistance of the gels resulting in robust resistance to cell adhesion (right).
Publisher: Informa UK Limited
Date: 13-01-2021
Publisher: Elsevier BV
Date: 02-2018
Publisher: Springer Berlin Heidelberg
Date: 2015
Publisher: Springer Berlin Heidelberg
Date: 2015
Publisher: Informa UK Limited
Date: 06-09-2022
Publisher: Emerald Publishing Limited
Date: 26-07-2021
Publisher: IBM
Date: 2008
DOI: 10.1147/SJ.471.0129
Publisher: Elsevier BV
Date: 04-2016
Publisher: Emerald
Date: 05-1993
Publisher: Springer US
Date: 2006
Publisher: Elsevier BV
Date: 11-2020
Start Date: 12-2002
End Date: 12-2005
Amount: $67,635.00
Funder: Australian Research Council
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