ORCID Profile
0000-0002-1655-1275
Current Organisation
Vaccine and Infectious Disease Organization International Vaccine Centre
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Publisher: Elsevier BV
Date: 10-2017
DOI: 10.1016/J.CARBPOL.2017.06.008
Abstract: Crosslinked carboxymethyl cellulose grafted carboxymethyl polyvinyl alcohol (CMC-g-CMPVA) was loaded with modified magnetite iron oxide (Fe
Publisher: MDPI AG
Date: 17-05-2021
DOI: 10.3390/GELS7020060
Abstract: With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by erse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.
Publisher: Springer Science and Business Media LLC
Date: 09-09-2017
Publisher: Wiley
Date: 23-09-2016
DOI: 10.1002/APP.44271
Publisher: Springer Science and Business Media LLC
Date: 22-05-2018
Publisher: MDPI AG
Date: 27-09-2021
DOI: 10.3390/GELS7040153
Abstract: Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.
Publisher: Institution of Engineering and Technology (IET)
Date: 28-02-2018
Location: Canada
No related grants have been discovered for Nuraina Anisa Dahlan.