ORCID Profile
0000-0001-9790-808X
Current Organisation
INSERM
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Publisher: Frontiers Media SA
Date: 29-01-2015
Publisher: MDPI AG
Date: 16-10-2019
Abstract: Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.
Location: Spain
No related grants have been discovered for María Jesús García-León.