ORCID Profile
0000-0002-4331-1250
Current Organisation
University of Zurich
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Publisher: Springer Science and Business Media LLC
Date: 22-02-2021
DOI: 10.1038/S43247-021-00112-Y
Abstract: As planetary boundaries loom, there is an urgent need to develop sustainable equilibriums between societies and the resources they consume, thereby avoiding regime shifts to undesired states. Transient system trajectories to a stable state may differ substantially, posing significant challenges to distinguishing sustainable from unsustainable trajectories. We use stylized models to show how feedbacks between anthropogenic harvest regimes and resource availability drive transient dynamics. We show how substantial time lags may occur between interventions and social-ecological outcomes, and that sudden system collapses need not be linked to recent environmental changes. Historical reconstructions of island state populations show a variety of transient dynamics that closely corresponds to model expectations based on island differences in productivity and harvesting regime. We conclude that vulnerable social-ecological systems may persist when the population:resource ratio remains within a viable range of intermediate (rather than small) values, which implies that averting environmental crises may require counter-intuitive measures.
Publisher: Springer Science and Business Media LLC
Date: 26-04-2022
Publisher: Elsevier BV
Date: 07-2021
Publisher: Wiley
Date: 08-06-2020
Publisher: Cold Spring Harbor Laboratory
Date: 27-11-2022
DOI: 10.1101/2022.11.25.22282723
Abstract: A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight after term delivery as a proxy for placental growth, we report genome-wide association analyses in the fetal ( n = 65,405), maternal ( n = 61,228), and paternal ( n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are confidently classified as fetal only, four maternal only, and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1 . Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but twelve loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with risk of preecl sia or shorter gestational duration. Moreover, these analyses support a role for insulin produced by the fetus in regulating the growth of the placenta, providing a key link between fetal and placental growth.
Publisher: Elsevier BV
Date: 07-2021
No related grants have been discovered for Cathrine Ebbing.