ORCID Profile
0000-0001-7633-9455
Current Organisation
University of Reading
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Publisher: JMIR Publications Inc.
Date: 30-06-2016
DOI: 10.2196/JMIR.5620
Publisher: MDPI AG
Date: 23-01-2021
DOI: 10.3390/NU13020326
Abstract: Metabolic diseases have been shown to be associated with low vitamin D status however, the findings have been inconsistent. Hence, the objective of our study was to investigate the relationship between vitamin D status and metabolic disease-related traits in healthy Southeast Asian women and examine whether this relationship was modified by dietary factors using a nutrigenetic study. The study included 110 Minangkabau women (age: 25–60 years) from Padang, Indonesia. Genetic risk scores (GRS) were constructed based on five vitamin D-related single nucleotide polymorphisms (SNPs) (vitamin D-GRS) and ten metabolic disease-associated SNPs (metabolic-GRS). The metabolic-GRS was significantly associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations (p = 0.009) and higher body mass index (BMI) (p = 0.016). Even though the vitamin D-GRS had no effect on metabolic traits (p 0.12), an interaction was observed between the vitamin D-GRS and carbohydrate intake (g) on body fat percentage (BFP) (pinteraction = 0.049), where those in iduals who consumed a high carbohydrate diet (mean ± SD: 319 g/d ± 46) and carried vitamin D-lowering risk alleles had significantly higher BFP (p = 0.016). In summary, we have replicated the association of metabolic-GRS with higher BMI and lower 25(OH)D concentrations and identified a novel interaction between vitamin D-GRS and carbohydrate intake on body fat composition.
Publisher: JMIR Publications Inc.
Date: 14-10-2015
DOI: 10.2196/JMIR.4660
Publisher: JMIR Publications Inc.
Date: 05-02-2016
DOI: 10.2196/JMIR.5198
Publisher: JMIR Publications Inc.
Date: 10-08-2017
Publisher: JMIR Publications Inc.
Date: 09-04-2018
DOI: 10.2196/RESPROT.8703
Publisher: JMIR Publications Inc.
Date: 10-08-2017
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Julie Lovegrove.