ORCID Profile
0000-0002-5859-808X
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Chemical Engineering | Chemical Engineering not elsewhere classified | Chemical Engineering Design | Fluidisation and Fluid Mechanics | Catalytic Process Engineering | Food Engineering | Powder and Particle Technology | Process Control and Simulation | Non-automotive Combustion and Fuel Engineering (incl. Alternative/Renewable Fuels) | Food Sciences | Functional Materials | Crop and Pasture Biomass and Bioproducts | Interdisciplinary Engineering | Cell Metabolism |
ANZSRC Socio-Economic Objective (SEO)
Primary Mining and Extraction of Mineral Resources not elsewhere classified | Oil and Gas Refining | Solid Oxide Fuel Cells | Energy not elsewhere classified | Expanding Knowledge in Engineering | Inorganic industrial chemicals | Energy Conservation and Efficiency not elsewhere classified | Lupins | Nutraceuticals and Functional foods | Beneficiation or dressing of non-metallic minerals (incl. diamonds) | Energy minerals not elsewhere classified | Ceramics
Related Links
Publications
Gas-solid flow hydrodynamics of an industrial scale catalyst lift engager
Publisher: Elsevier BV
Date: 05-2010
Simulation and Analysis of Carbon-in-Leach (CIL) Circuits
Publisher: Elsevier
Date: 2012
Effect of closure models on Eulerian-Eulerian gas-solid flow predictions in riser
Publisher: Elsevier BV
Date: 2014
Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury.
Publisher: Wiley
Date: 24-02-2021
DOI: 10.1111/JCPP.13385
Abstract: Despite increasing evidence of a link between early life brain injury and anti‐social behavior, very few studies have assessed factors that explain this association in children with traumatic brain injury (TBI). One hypothesis suggests that childhood TBI elevates risk for anti‐social behavior via disruption to anatomically distributed neural networks implicated in executive functioning (EF). In this longitudinal prospective study, we employed high‐resolution structural neuroimaging to (a) evaluate the impact of childhood TBI on regional morphometry of the central executive network (CEN) and (b) evaluate the prediction that lower EF mediates the prospective relationship between structural differences within the CEN and postinjury anti‐social behaviors. This study involved 155 children, including 112 consecutively recruited, hospital‐confirmed cases of mild‐severe TBI and 43 typically developing control (TDC) children. T1‐weighted brain magnetic resonance imaging (MRI) sequences were acquired sub‐acutely in a subset of 137 children [TBI: n = 103 TDC: n = 34]. All participants were evaluated using direct assessment of EF 6 months postinjury, and parents provided ratings of anti‐social behavior 12 months postinjury. Severe TBI was associated with postinjury volumetric differences within the CEN and its putative hub regions. When compared with TD controls, the TBI group had significantly worse EF, which was associated with more frequent anti‐social behaviors and abnormal CEN morphometry. Mediation analysis indicated that reduced EF mediated the prospective association between postinjury volumetric differences within the CEN and more frequent anti‐social behavior. Our longitudinal prospective findings suggest that detection of neurostructural abnormalities within the CEN may aid in the early identification of children at elevated risk for postinjury executive dysfunction, which may in turn contribute to chronic anti‐social behaviors after early life brain injury. Findings underscore the potential value of early surveillance and preventive measures for children presenting with neurostructural and/or neurocognitive risk factors.
Numerical study of fog formation around ambient air vaporizers
Publisher: Elsevier BV
Date: 06-2018
CFD Modelling of Flow and Solids Distribution in Carbon-in-Leach Tanks
Publisher: MDPI AG
Date: 28-10-2015
DOI: 10.3390/MET5041997
Modelling and numerical simulation of liquid–solid circulating fluidized bed system for protein purification
Publisher: Elsevier BV
Date: 09-2013
Vortex shape and gas‐liquid hydrodynamics in unbaffled stirred tank
Publisher: Wiley
Date: 17-02-2019
DOI: 10.1002/CJCE.23433
Evaporation of a droplet on a heated spherical particle
Publisher: Elsevier BV
Date: 10-2015
Modelling of the interaction between a falling n-heptane droplet and hot solid surface
Publisher: Elsevier BV
Date: 09-2014
Verification of EMMS formulation using lattice Boltzmann simulations
Publisher: Elsevier BV
Date: 05-2014
Characteristics of energy production and dissipation around a bubble rising in water
Publisher: Elsevier BV
Date: 2019
Effect of inlet boundary conditions on computational fluid dynamics (CFD) simulations of gas-solid flows in risers
Publisher: American Chemical Society (ACS)
Date: 30-09-2012
DOI: 10.1021/IE200940F
Lupin seed γ-conglutin: Extraction and purification methods - A review
Publisher: Elsevier BV
Date: 03-2018
Particle deposition in natural gas pipelines using computational fluid dynamics modelling
Publisher: Wiley
Date: 27-12-2012
DOI: 10.1002/APJ.648
Effect of a cluster on gas-solid drag from lattice Boltzmann simulations
Publisher: Elsevier BV
Date: 10-2013
Hydrodynamic study of fluid catalytic cracker unit stripper
Publisher: American Chemical Society (ACS)
Date: 18-03-2013
DOI: 10.1021/IE300828N
CFD simulation of solid–liquid stirred tanks for low to dense solid loading systems
Publisher: Elsevier BV
Date: 12-2016
The health of adolescents in detention: a global scoping review
Publisher: Elsevier BV
Date: 02-2020
CFD study: Effect of pulsating flow on gas–solid hydrodynamics in FCC riser
Publisher: Elsevier BV
Date: 04-2017
Prevalence and predictors of externalizing behavior in young adult survivors of pediatric traumatic brain injury
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 03-2015
Modeling and optimization of Carbon in leach (CIL) circuit for gold recovery
Publisher: Elsevier BV
Date: 11-2015
Droplet impact dynamics on a spherical particle
Publisher: Elsevier BV
Date: 08-2013
The health of children deprived of liberty: a human rights issue
Publisher: Elsevier BV
Date: 2020
Effect of drag models on CFD–DEM predictions of bubbling fluidized beds with Geldart D particles
Publisher: Elsevier BV
Date: 11-2018
Bubbles in viscous liquids: Time dependent behaviour and wake characteristics
Publisher: Elsevier BV
Date: 04-2016
Dynamic tank in series modeling of direct internal reforming SOFC
Publisher: Hindawi Limited
Date: 06-03-2017
DOI: 10.1002/ER.3733
Estimation of Bubble Properties in Bubbling Fluidized Bed Using ECVT Measurements
Publisher: American Chemical Society (ACS)
Date: 30-05-2018
Effect of baffles on performance of fluid catalytic cracking riser
Publisher: Elsevier BV
Date: 06-2018
Hydrodynamics of an FCC riser using energy minimization multiscale drag model
Publisher: Elsevier BV
Date: 04-2011
Impact of HSPBT blade angle on gas phase hydrodynamics in a gas–liquid stirred tank
Publisher: Elsevier BV
Date: 02-2202
Language impairment and comorbid vulnerabilities among young people in custody
Publisher: Wiley
Date: 22-08-2017
DOI: 10.1111/JCPP.12791
Abstract: While the prevalence of language and communication difficulties among young people in custody is well established, holistic understanding of the complexity and co-occurrence of additional vulnerabilities among this population are rare. Ninety-three young people in a young offenders institution in England were assessed using the Comprehensive Health Assessment Tool, the Test of Word Knowledge, and a range of additional assessments of communication, cognition, and neurodevelopmental difficulties. Forty-seven percent of the young people demonstrated an aspect of language skills significantly below the population average, with more than one in four identified as having impairment. Only one in four of those with an impairment had previously accessed speech and language services. Language needs were associated with difficulties with social communication and nonverbal cognition, as well as higher risk of self-harm and substance misuse. Earlier identification of language difficulties requires routine assessment of young people at risk of engagement in offending behavior. Where language difficulties are identified, holistic assessments of needs should be undertaken. There is a need for speech and language therapy provision within youth justice services, as well as in other services accessed by young people at risk of engagement in offending.
Children and Crime: In the Moment
Publisher: SAGE Publications
Date: 12-06-2020
Abstract: Traditional approaches to understanding and responding to children and crime are fundamentally based on ‘miniaturised’ adult models. The assumption appears to be that children are adults in the making, essentially just smaller, developing versions of grown-ups. This view of children is increasingly being challenged. Children are not simply putative adults, they are different, distinct and developing. This article sets out to explore the notion that children essentially think and behave ‘in the moment’. The implications of this for our understanding of children and crime are also explored.
CFD simulation of solid-liquid stirred tanks
Publisher: Elsevier BV
Date: 07-2012
Reverse phase HPLC method for detection and quantification of lupin seed γ-conglutin
Publisher: Elsevier BV
Date: 09-2017
DOI: 10.1016/J.JCHROMB.2017.08.025
Abstract: A simple, selective and accurate reverse phase HPLC method was developed for detection and quantitation of γ-conglutin from lupin seed extract. A linear gradient of water and acetonitrile containing trifluoroacetic acid (TFA) on a reverse phase column (Agilent Zorbax 300SB C-18), with a flow rate of 0.8ml/min was able to produce a sharp and symmetric peak of γ-conglutin with a retention time at 29.16min. The identity of γ-conglutin in the peak was confirmed by mass spectrometry (MS/MS identification) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. The data obtained from MS/MS analysis was matched against the specified database to obtain the exact match for the protein of interest. The proposed method was validated in terms of specificity, linearity, sensitivity, precision, recovery and accuracy. The analytical parameters revealed that the validated method was capable of selectively performing a good chromatographic separation of γ-conglutin from the lupin seed extract with no interference of the matrix. The detection and quantitation limit of γ-conglutin were found to be 2.68μg/ml and 8.12μg/ml respectively. The accuracy (precision and recovery) analysis of the method was conducted under repeatable conditions on different days. Intra-day and inter-day precision values less than 0.5% and recovery greater than 97% indicated high precision and accuracy of the method for analysis of γ-conglutin. The method validation findings were reproducible and can be successfully applied for routine analysis of γ-conglutin from lupin seed extract.
Simultaneous estimation of states and inputs in a planar solid oxide fuel cell using nonlinear adaptive observer design
Publisher: Elsevier BV
Date: 02-2014
Hydrodynamics of a fluid catalytic cracking stripper using γ-ray densitometry
Publisher: American Chemical Society (ACS)
Date: 19-04-2011
DOI: 10.1021/IE1021877
Interaction of bubbles rising inline in quiescent liquid
Publisher: Elsevier BV
Date: 07-2017
Planar SOFC system modelling and simulation including a 3D stack module
Publisher: Elsevier BV
Date: 2016
Computational fluid dynamic modelling of FCC riser: A review
Publisher: Elsevier BV
Date: 07-2016
Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds
Publisher: Elsevier BV
Date: 12-2021
Solid oxide fuel cell reactor analysis and optimisation through a novel multi-scale modelling strategy
Publisher: Elsevier BV
Date: 07-2015
Family and Community Predictors of Comorbid Language, Socioemotional and Behavior Problems at School Entry
Publisher: Public Library of Science (PLoS)
Date: 05-07-2016
Computational fluid dynamics analysis of liquefied natural gas dispersion for risk assessment strategies
Publisher: Elsevier BV
Date: 2013
Modeling of Cryogenic Liquefied Natural Gas Ambient Air Vaporizers
Publisher: American Chemical Society (ACS)
Date: 07-06-2018
Nivolumab in the treatment of advanced renal cell carcinoma
Publisher: Future Medicine Ltd
Date: 07-2018
Abstract: Renal cell carcinoma (RCC) has typically been considered an immunogenic malignancy with responses seen to IL-2 and IFN-α. Response rates, however, were low and at the cost of considerable toxicity and as such, agents targeting angiogenesis have become the mainstay of treatment. Nivolumab is an immune checkpoint inhibitor targeting PD-1 thereby upregulating the host immune response against tumor cells. Nivolumab has emerged as a promising new therapy in advanced malignancies, and the first agent to show survival advantage in patients failing prior VEGFR-targeted therapy in metastatic RCC. This review summarizes the present evidence, toxicity profile, potential predictive biomarkers and promising future strategies with nivolumab in metastatic RCC.
Simulation of gas-solid flows in riser using energy minimization multiscale model: Effect of cluster diameter correlation
Publisher: Elsevier BV
Date: 07-2011
Physicochemical characterisation of kafirins extracted from sorghum grain and dried distillers grain with solubles related to their biomaterial functionality
Publisher: Springer Science and Business Media LLC
Date: 26-07-2021
DOI: 10.1038/S41598-021-94718-Z
Abstract: Kafirin, the hydrophobic prolamin storage protein in sorghum grain is enriched when the grain is used for bioethanol production to give dried distillers grain with solubles (DGGS) as a by-product. There is great interest in DDGS kafirin as a new source for biomaterials. There is however a lack of fundamental understanding of how the physicochemical properties of DDGS kafirin having been exposed to the high temperature conditions during ethanol production, compare to kafirin made directly from the grain. An understanding of these properties is required to catalyse the utilisation of DDGS kafirin for biomaterial applications. The aim of this study was to extract kafirin directly from sorghum grain and from DDGS derived from the same grain and, then perform a comparative investigation of the physicochemical properties of these kafirins in terms of: polypeptide profile by sodium-dodecyl sulphate polyacrylamide gel electrophoresis secondary structure by Fourier transform infra-red spectroscopy and x-ray diffraction, self-assembly behaviour by small-angle x-ray scattering, surface morphology by scanning electron microscopy and surface chemical properties by energy dispersive x-ray spectroscopy. DDGS kafirin was found to have very similar polypeptide profile as grain kafirin but contained altered secondary structure with increased levels of β-sheets. The structure morphology showed surface fractals and surface elemental composition suggesting enhanced reactivity with possibility to endow interfacial wettability. These properties of DDGS kafirin may provide it with unique functionality and thus open up opportunities for it to be used as a novel food grade biomaterial.
Traumatic brain injury and homelessness: from prevalence to prevention.
Publisher: Elsevier BV
Date: 2019
Kafirin adsorption on ion-exchange resins: Isotherm and kinetic studies
Publisher: Elsevier BV
Date: 08-2014
DOI: 10.1016/J.CHROMA.2014.06.035
Abstract: Kafirin is a natural, hydrophobic and celiac safe prolamin protein obtained from sorghum seeds. Today kafirin is found to be useful in designing delayed delivery systems and coatings of pharmaceuticals and nutraceuticals where its purity is important and this can be obtained by adsorptive chromatography. This study is the first scientific insight into the isotherm and kinetic studies of kafirin adsorption on anion- and cation-exchange resins for practical applications in preparative scale chromatography. Adsorption isotherms of kafirin were determined for five anion- and two cation-exchange resins in batch systems. Isotherm parameters such as maximum binding capacity and dissociation constant were determined from Langmuir isotherm, and adsorptive capacity and affinity constant from Freundlich isotherm. Langmuir isotherm was found to fit the adsorption equilibrium data well. Batch uptake kinetics for kafirin adsorption on these resins was also carried out and critical parameters including the diffusion coefficient, film mass transfer coefficient, and Biot number for film-pore diffusion model were calculated. Both the isotherm and the kinetic parameters were considered for selection of appropriate resin for kafirin purification. UNOsphere Q (78.26 mg/ml) and Toyopearl SP-650M (57.4 mg/ml) were found to offer better kafirin binding capacities and interaction strength with excellent uptake kinetics under moderate operating conditions. With these adsorbents, film diffusion resistance was found to be major governing factor for adsorption (Bi<10 and δ<1). Based on designer objective function, UNOsphere Q was found be best adsorbent for binding of kafirin. The data presented is valuable for designing large scale preparative adsorptive chromatographic kafirin purification systems.
Related Organisations
No related organisations have been discovered for Nathan Hughes.
Related Funding Activities
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100211
Start Date: 10-2012
End Date: 08-2017
Amount: $230,000.00
Funder: Australian Research Council
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End Date: 11-2023
Amount: $313,304.00
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View Funded ActivityLinkage Projects - Grant ID: LP110100717
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View Funded ActivityLinkage Projects - Grant ID: LP160101181
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End Date: 12-2019
Amount: $410,000.00
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View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE100100155
Start Date: 2010
End Date: 12-2010
Amount: $495,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE110100160
Start Date: 08-2011
End Date: 07-2012
Amount: $190,000.00
Funder: Australian Research Council
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End Date: 04-2015
Amount: $180,000.00
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View Funded ActivityDiscovery Projects - Grant ID: DP220103669
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End Date: 12-2025
Amount: $370,000.00
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