ORCID Profile
0000-0002-6804-4128
Current Organisation
Tampere University
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Publisher: Springer Science and Business Media LLC
Date: 29-11-2021
DOI: 10.1038/S41467-021-27220-9
Abstract: Breast cancer is now globally the most frequent cancer and leading cause of women’s death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα + ) phenotype that is initially responsive to antihormonal therapies, but drug resistance emerges. A major barrier to the understanding of the ERα-pathway biology and therapeutic discoveries is the restricted repertoire of luminal ERα + breast cancer models. The ERα + phenotype is not stable in cultured cells for reasons not fully understood. We examine 400 patient-derived breast epithelial and breast cancer explant cultures (PDECs) grown in various three-dimensional matrix scaffolds, finding that ERα is primarily regulated by the matrix stiffness. Matrix stiffness upregulates the ERα signaling via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation. The finding that the matrix stiffness is a central cue to the ERα phenotype reveals a mechanobiological component in breast tissue hormonal signaling and enables the development of novel therapeutic interventions. Subject terms: ER-positive (ER + ), breast cancer, ex vivo model, preclinical model, PDEC, stiffness, p38 SAPK.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7PY01814B
Abstract: Precisely grafted polymer brushes on cellulose nanocrystals guide the formation of silica and yield uniform CNC-based hybrid nanomaterials which are subsequently used in the fabrication of hollow and highly porous silica nanorods.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR03263C
Abstract: Upon changing the position, nature and number of the halogen atoms, the same amyloidogenic peptide self-assembles into different nanostructures.
Publisher: American Chemical Society (ACS)
Date: 16-01-2019
Publisher: Wiley
Date: 24-07-2017
Publisher: American Chemical Society (ACS)
Date: 27-09-2018
DOI: 10.1021/JACS.8B08870
Abstract: The construction of precise soft matter nanostructures in solution presents a challenge. A key focus remains on the rational design of functionalities to achieve the high morphological complexity typically found in biological systems. Advances in controlled polymerizations and self-assembly increasingly allow approaches toward complex hierarchical nanomaterials. By combining tailor-made cylindrical polymer brushes, block copolymers and interpolyelectrolyte complexation-driven self-assembly, we demonstrate a facile construction of uniformly compartmentalized and topographically structured polymeric nanowires in aqueous media. The approach offers a modular avenue in programming the internal morphology of polymer nanowires by varying the block copolymer composition and topology.
Publisher: American Chemical Society (ACS)
Date: 10-08-2023
Location: No location found
No related grants have been discovered for Nonappa Nonappa.