ORCID Profile
0000-0002-9403-5882
Current Organisation
Griffith University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Chemical Engineering Design | Chemical Engineering | Mechanical Engineering | Microtechnology | Microelectromechanical Systems (MEMS) |
ANZSRC Socio-Economic Objective (SEO)
Diagnostic Methods | Expanding Knowledge in the Physical Sciences | Scientific Instruments | Management of Solid Waste from Manufacturing Activities | Expanding Knowledge in Engineering | Expanding Knowledge in Technology
Related Links
Publications
Oscillating sessile liquid marble - A tool to assess effective surface tension
Publisher: Elsevier BV
Date: 10-2021
Loop-mediated isothermal amplification in a core-shell bead assay for the detection of tyrosine kinase axl overexpression
Publisher: MDPI AG
Date: 30-07-2021
DOI: 10.3390/MI12080905
Abstract: The upregulated expression of tyrosine kinase AXL has been reported in several hematologic and solid human tumors, including gastric, breast, colorectal, prostate and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first ever loop-mediated isothermal lification (LAMP) in a core-shell bead assay for the detection of AXL gene overexpression. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally-friendly laboratory practices.
A floating self-propelling liquid marble containing aqueous ethanol solutions
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5RA23946J
Abstract: We report the behaviour of a self-propelling liquid marble containing an aqueous ethanol solution.
Modelling Sessile Droplet Profile Using Asymmetrical Ellipses
Publisher: MDPI AG
Date: 20-11-2021
DOI: 10.3390/PR9112081
Abstract: Modelling the profile of a liquid droplet has been a mainstream technique for researchers to study the physical properties of a liquid. This study proposes a facile modelling approach using an elliptic model to generate the profile of sessile droplets, with MATLAB as the simulation environment. The concept of the elliptic method is simple and easy to use. Only three specific points on the droplet are needed to generate the complete theoretical droplet profile along with its critical parameters such as volume, surface area, height, and contact radius. In addition, we introduced fitting coefficients to accurately determine the contact angle and surface tension of a droplet. Droplet volumes ranging from 1 to 300 µL were chosen for this investigation, with contact angles ranging from 90° to 180°. Our proposed method was also applied to images of actual water droplets with good results. This study demonstrates that the elliptic method is in excellent agreement with the Young–Laplace equation and can be used for rapid and accurate approximation of liquid droplet profiles to determine the surface tension and contact angle.
Direct Measurement of the Contents, Thickness, and Internal Pressure of Molybdenum Disulfide Nanoblisters
Publisher: American Chemical Society (ACS)
Date: 09-04-2020
Measuring the Coefficient of Friction of a Small Floating Liquid Marble
Publisher: Springer Science and Business Media LLC
Date: 02-12-2016
DOI: 10.1038/SREP38346
Abstract: This paper investigates the friction coefficient of a moving liquid marble, a small liquid droplet coated with hydrophobic powder and floating on another liquid surface. A floating marble can easily move across water surface due to the low friction, allowing for the transport of aqueous solutions with minimal energy input. However, the motion of a floating marble has yet to be systematically characterised due to the lack of insight into key parameters such as the coefficient of friction between the floating marble and the carrier liquid. We measured the coefficient of friction of a small floating marble using a novel experimental setup that exploits the non-wetting properties of a liquid marble. A floating liquid marble pair containing a minute amount magnetite particles were immobilised and then released in a controlled manner using permanent magnets. The capillarity-driven motion was analysed to determine the coefficient of friction of the liquid marbles. The “capillary charge” model was used to fit the experimental results. We varied the marble content and carrier liquid to establish a relationship between the friction correction factor and the meniscus angle.
Electrostatically excited liquid marble as a micromixer
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1RE00121C
Abstract: Liquid marble as a micromixer. Particles suspended in a transparent liquid marble is dispersed in a time lapse photo. The colour change from red to purple shows the particle position from the first frame to the last frame.
An automated on-demand liquid marble generator based on electrohydrodynamic pulling
Publisher: AIP Publishing
Date: 05-2019
DOI: 10.1063/1.5094522
Abstract: Liquid marble is a recently emerging digital microfluidic platform with a wide range of applications. Conventional liquid marbles are synthesized by coating liquid droplets with a thin layer of hydrophobic powder. Existing and emerging applications of liquid marbles require a contamination-free synthesis of liquid marbles with a high degree of reproducibility of their volume. Despite this requirement, the synthesis of liquid marbles has been still carried out manually. Manual production of liquid marbles leads to inconsistent volume and the possibility of contamination. The synthesis of liquid marbles with submicroliter volume is difficult to achieve and prone to large errors. This paper discusses the design and development of the first automated on-demand liquid marble generator with submicroliter capability. The device utilizes electrohydrodynamic pulling of liquid droplets on to a hydrophobic powder bed and subsequently coats them with the hydrophobic powder to synthesize liquid marbles of a desired volume.
Liquid Marbles as Miniature Reactors for Chemical and Biological Applications
Publisher: MDPI AG
Date: 07-07-2020
DOI: 10.3390/PR8070793
Abstract: The need for miniaturised reaction systems has led to the development of various microreactor platforms, such as droplet-based microreactors. However, these microreactors possess inherent drawbacks, such as rapid evaporation and difficult handling, that limit their use in practical applications. Liquid marbles are droplets covered with hydrophobic particles and are a potential platform that can overcome the weaknesses of bare droplets. The coating particles completely isolate the interior liquids from the surrounding environment, thus conveniently encapsulating the reactions. Great efforts have been made over the past decade to demonstrate the feasibility of liquid marble-based microreactors for chemical and biological applications. This review systemically summarises state-of-the-art implementations of liquid marbles as microreactors. This paper also discusses the various aspects of liquid marble-based microreactors, such as the formation, manipulation, and future perspectives.
Fundamentals of differential particle inertial focusing in symmetric sinusoidal microchannels
Publisher: American Chemical Society (ACS)
Date: 23-01-2019
DOI: 10.1021/ACS.ANALCHEM.8B05712
Abstract: Focusing and separation of particles such as cells at high throughput is extremely attractive for biomedical applications. Particle manipulation based on inertial effects requires a high flow speed and thus is well-suited to high-throughput applications. Recently, inertial focusing and separation using curvilinear microchannels has been attracting a great amount of interest because of the linear structure for parallelization, small device footprint, superior particle-focusing performance, and easy implementation of particle separation. However, the curvature directions of these microchannels alternate, leading to variations in both the magnitude and direction of the induced secondary flow. Accumulation of this variation along the channel causes unpredictable behaviors of particles. This paper systematically investigates the inertial-focusing phenomenon in low-aspect-ratio symmetric sinusoidal channels. First, we comprehensively studied the effects of parameters such as viscosity, flow conditions, particle size, and geometric dimensions of the microchannel on differential particle focusing. We found that particle inertial focusing is generally independent of fluid kinematic viscosity but highly dependent on particle size, flow conditions, and channel dimensions. Next, we derived an explicit scaling factor and included all four dimensionless parameters (particle-blockage ratio, curvature ratio, Dean number, and channel aspect ratio) in a single operational map to illustrate the particle-focusing patterns. Finally, we proposed a rational guideline to intuitively instruct the design of channel dimensions for separation of a given particle mixture.
Dynamic behaviour of a magnetically actuated floating liquid marble
Publisher: Springer Science and Business Media LLC
Date: 06-2017
Digital microfluidics with a magnetically actuated floating liquid marble
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6LC00378H
Abstract: We report a digital microfluidics platform based on floating liquid marbles.
Evaporation of Ethanol–Water Binary Mixture Sessile Liquid Marbles
Publisher: American Chemical Society (ACS)
Date: 09-06-2016
DOI: 10.1021/ACS.LANGMUIR.6B01272
Abstract: Liquid marble is a liquid droplet coated with particles. Recently, the evaporation process of a sessile liquid marble using geometric measurements has attracted great attention from the research community. However, the lack of gravimetric measurement limits further insights into the physical changes of a liquid marble during the evaporation process. Moreover, the evaporation process of a marble containing a liquid binary mixture has not been reported before. The present paper investigates the effective density and the effective surface tension of an evaporating liquid marble that contains aqueous ethanol at relatively low concentrations. The effective density of an evaporating liquid marble is determined from the concurrent measurement of instantaneous mass and volume. Density measurements combined with surface profile fitting provide the effective surface tension of the marble. We found that the density and surface tension of an evaporating marble are significantly affected by the particle coating.
Measuring the effective surface tension of a floating liquid marble using X-ray imaging
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SM00101A
Abstract: Liquid marbles are non-wetting droplets coated with microscopic powder. We measure the effective surface tension of a liquid marble using X-ray which reveals the hidden liquid–solid interface. A systematic curve fitting procedure is also provided.
Digital Imaging‐based Colourimetry for Enzymatic Processes in Transparent Liquid Marbles
Publisher: Wiley
Date: 26-11-2020
A stretchable micromixer with enhanced performance for intermediate Reynolds numbers
Publisher: Research Square Platform LLC
Date: 03-09-2021
DOI: 10.21203/RS.3.RS-870684/V2
Abstract: Chemical reactions in microscale require good mixing at a relatively low flowrate. However, mixing in microscale faces the major challenge of stable laminar flow associated with the low Reynolds number, the relative ratio between inertial force and viscous force. For low Reynolds numbers of less than unity, mixing occurs due to molecular diffusion. For high Reynolds number of more than several tens, chaotic advection enhances mixing. However, in the intermediate regime, mixing is not efficient. This paper reports a stretchable micromixer with dynamically tuneable channel dimensions. Periodically stretching the device changes the channel geometry and the curvature induced secondary Dean flows. The dynamically evolving secondary and main flows in the mixing channel result in chaotic advection and enhance mixing. The concept was demonstrated in a stretchable micromixer with a serpentine channel. We evaluated the performance of this stretchable micromixer both experimentally and numerically. At the intermediate range of Reynolds numbers from 4 to 17, the periodically stretched micromixer showed a better mixing efficiency than the non-stretched counterpart. Therefore, our stretchable micromixer is a potential candidate for applications where precious reagents need to be mixed at relatively low flow rate conditions.
Precise, wide field, and low-cost imaging and analysis of core–shell beads for digital polymerase chain reaction
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3LC00337J
Abstract: This study introduces a core–shell bead-based digital PCR platform, where PCR mix is enclosed in microfluidic beads. Multiple flow focusing stages in the device facilitate bead formation. Results of digital PCR are effectively compared with RT-qPCR.
A stretchable micrometer with enhanced performance for intermediate Reynolds numbers
Publisher: Research Square Platform LLC
Date: 02-09-2021
DOI: 10.21203/RS.3.RS-870684/V1
Abstract: Chemical reactions in microscale require good mixing at a relatively low flowrate. However, mixing in microscale faces the major challenge of stable laminar flow associated with the low Reynolds number, the relative ratio between inertial force and viscous force. For low Reynolds numbers of less than unity, mixing occurs due to molecular diffusion. For high Reynolds number of more than several tens, chaotic advection enhances mixing. However, in the intermediate regime, mixing is not efficient. This paper reports a stretchable micromixer with dynamically tuneable channel dimensions. Periodically stretching the device changes the channel geometry and the curvature induced secondary Dean flows. The dynamically evolving secondary and main flows in the mixing channel result in chaotic advection and enhance mixing. The concept was demonstrated in a stretchable micromixer with a serpentine channel. We evaluated the performance of this stretchable micromixer both experimentally and numerically. At the intermediate range of Reynolds numbers from 4 to 17, the periodically stretched micromixer showed a better mixing efficiency than the non-stretched counterpart. Therefore, our stretchable micromixer is a potential candidate for applications where precious reagents need to be mixed at relatively low flow rate conditions.
Dielectrophoretic Trapping of a Floating Liquid Marble
Publisher: American Physical Society (APS)
Date: 18-04-2019
Liquid marble coalescence via vertical collision
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SM00121A
Abstract: We determined the critical condition for the coalescence of two identical liquid marbles through collision.
Loop-Mediated Isothermal Amplification in Core-Shell Beads Assay for the Detection of Tyrosine Kinase AXL Over Expression
Publisher: MDPI AG
Date: 08-07-2021
DOI: 10.20944/PREPRINTS202107.0195.V1
Abstract: The upregulated expression of thyrosine kinase AXL has been reported in several hematologic and solid human tumors including gastric, breast, colorectal, prostate, and ovarian cancers. Thus, AXL can potentially serve as a diagnostic and prognostic biomarker for various cancers. This paper reports the first-ever use of loop-mediated isothermal lification (LAMP) of the AXL gene as a diagnostic method for ovarian cancer. We demonstrated simple instrumentation toward a point-of-care device to perform LAMP. This paper also reports the first-ever use of core-shell beads as a microreactor to perform LAMP as an attempt to promote environmentally friendly laboratory practices.
Dynamic Behaviours of Monodisperse Double Emulsion Formation in a Tri-Axial Capillary Device
Publisher: MDPI AG
Date: 31-10-2022
DOI: 10.3390/MI13111877
Abstract: We investigated experimentally, analytically, and numerically the formation process of double emulsion formations under a dripping regime in a tri-axial co-flow capillary device. The results show that mismatches of core and shell droplets under a given flow condition can be captured both experimentally and numerically. We propose a semi-analytical model using the match ratio between the pinch-off length of the shell droplet and the product of the core growth rate and its pinch-off time. The mismatch issue can be avoided if the match ratio is lower than unity. We considered a model with the wall effect to predict the size of the matched double emulsion. The model shows slight deviations with experimental data if the Reynolds number of the continuous phase is lower than 0.06 but asymptotically approaches good agreement if the Reynolds number increases from 0.06 to 0.14. The numerical simulation generally agrees with the experiments under various flow conditions.
Core-Shell Beads as Microreactors for Phylogrouping of E. coli Strains
Publisher: MDPI AG
Date: 07-08-2020
DOI: 10.3390/MI11080761
Abstract: Multiplex polymerase chain reaction (PCR) is an effective tool for simultaneous detection of target genes. Nevertheless, their use has been restricted due to the intrinsic interference between primer pairs. Performing several single PCRs in an array format instead of a multiplex PCR is a simple way to overcome this obstacle. However, there are still major technical challenges in designing a new generation of single PCR microreactors with a small s le volume, rapid thermal cycling, and no evaporation during lification. We report a simple and robust core-shell bead array for a series of single lifications. Four core-shell beads with a polymer coating and PCR mixture were synthesized using liquid marble formation and subsequent photo polymerization. Each bead can detect one target gene. We constructed a customised system for thermal cycling of these core-shell beads. Phylogrouping of the E. coli strains was carried out based on the fluorescent signal of the core-shell beads. This platform can be a promising alternative for multiplex nucleic acid analyses due to its simplicity and high throughput. The platform reported here also reduces the cycling time and avoids evaporation as well as contamination of the s le during the lification process.
Floating mechanism of a small liquid marble
Publisher: Springer Science and Business Media LLC
Date: 23-02-2016
DOI: 10.1038/SREP21777
Abstract: Flotation of small solid objects and liquid droplets on water is critical to natural and industrial activities. This paper reports the floating mechanism of liquid marbles, or liquid droplets coated with hydrophobic microparticles. We used X-ray computed tomography (XCT) to acquire cross-sectional images of the floating liquid marble and interface between the different phases. We then analysed the shape of the liquid marble and the angles at the three-phase contact line (TPCL). We found that the small floating liquid marbles follow the mechanism governing the flotation of solid objects in terms of surface tension forces. However, the contact angles formed and deformation of the liquid marble resemble that of a sessile liquid droplet on a thin, elastic solid. For small liquid marbles, the contact angle varies with volume due to the deformability of the interface.
Uniaxial Cyclic Cell Stretching Device for Accelerating Cellular Studies
Publisher: MDPI AG
Date: 31-07-2023
DOI: 10.3390/MI14081537
Abstract: Cellular response to mechanical stimuli is a crucial factor for maintaining cell homeostasis. The interaction between the extracellular matrix and mechanical stress plays a significant role in organizing the cytoskeleton and aligning cells. Tools that apply mechanical forces to cells and tissues, as well as those capable of measuring the mechanical properties of biological cells, have greatly contributed to our understanding of fundamental mechanobiology. These tools have been extensively employed to unveil the substantial influence of mechanical cues on the development and progression of various diseases. In this report, we present an economical and high-performance uniaxial cell stretching device. This paper reports the detailed operation concept of the device, experimental design, and characterization. The device was tested with MDA-MB-231 breast cancer cells. The experimental results agree well with previously documented morphological changes resulting from stretching forces on cancer cells. Remarkably, our new device demonstrates comparable cellular changes within 30 min compared with the previous 2 h stretching duration. This third-generation device significantly improved the stretching capabilities compared with its previous counterparts, resulting in a remarkable reduction in stretching time and a substantial increase in overall efficiency. Moreover, the device design incorporates an open-source software interface, facilitating convenient parameter adjustments such as strain, stretching speed, frequency, and duration. Its versatility enables seamless integration with various optical microscopes, thereby yielding novel insights into the realm of mechanobiology.
Liquid marble – a high-yield micro-photobioreactor platform
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3RE00221G
Abstract: This paper demonstrates the use of a transparent liquid marble as a micro-photobioreactor for microalgal culture, with enhanced performance due to high light transmissivity and large surface area.
Generation of three-dimensional multiple spheroid model of olfactory ensheathing cells using floating liquid marbles.
Publisher: Springer Science and Business Media LLC
Date: 14-10-2015
DOI: 10.1038/SREP15083
Abstract: We describe a novel protocol for three-dimensional culturing of olfactory ensheathing cells (OECs), which can be used to understand how OECs interact with other cells in three dimensions. Transplantation of OECs is being trialled for repair of the paralysed spinal cord, with promising but variable results and thus the therapy needs improving. To date, studies of OEC behaviour in a multicellular environment have been h ered by the lack of suitable three-dimensional cell culture models. Here, we exploit the floating liquid marble, a liquid droplet coated with hydrophobic powder and placed on a liquid bath. The presence of the liquid bath increases the humidity and minimises the effect of evaporation. Floating liquid marbles allow the OECs to freely associate and interact to produce OEC spheroids with uniform shapes and sizes. In contrast, a sessile liquid marble on a solid surface suffers from evaporation and the cells aggregate with irregular shapes. We used floating liquid marbles to co-culture OECs with Schwann cells and astrocytes which formed natural structures without the confines of gels or bounding layers. This protocol can be used to determine how OECs and other cell types associate and interact while forming complex cell structures.
Manipulation of a floating liquid marble using dielectrophoresis
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8LC01057A
Abstract: A liquid marble is a microliter-sized droplet coated with hydrophobic powder.
Evaporation dynamics of liquid marbles at elevated temperatures
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8RA02265H
Abstract: We investigate the evaporation behaviour of a group of liquid marbles at elevated temperature under various conditions.
Manipulation of liquid marbles
Publisher: Springer Science and Business Media LLC
Date: 23-05-2015
Investigation of liquid marble shell using X‐ray: shell thickness and effective surface tension
Publisher: Wiley
Date: 12-2022
Abstract: Liquid marble is a non‐wetting droplet encapsulated by micro‐ or nano‐sized hydrophobic particles. Recently, liquid marble has been emerging as a tool for digital microfluidics. Thus, a detailed understanding of the fundamentals of liquid marble is essential. The shell of a liquid marble has an opaque and fuzzy appearance which hinders in‐depth investigation using conventional optical microscopy. We used X‐ray computerized microtomography (CMT) to generate an image with a visible interface between the core liquid and the shell to overcome this problem. The interface facilitates accurate measurement of the shell thickness and the effective surface tension. This work investigates the effect of liquid marble preparation methods and liquid marble volumes on shell thickness and effective surface tension. We found that increasing the revolution speed during liquid marble preparation increases shell thickness. A liquid marble shell has a uniform packing when the revolution speed is 200–300 rpm. We also found that the effective surface tension of liquid marbles decreases with increasing volume. This could be due to a stronger effect of gravitational force for a large liquid marble. The findings from this work could provide a new insight into the characterization of liquid marble and open up a new direction of fundamental research of liquid marble shell.
Digital polymerase chain reaction technology-recent advances and future perspectives
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8LC00990B
Abstract: We critically evaluate the state of the art of the development of digital polymerase chain reaction systems.
Wide-Band-Gap Semiconductors for Biointegrated Electronics: Recent Advances and Future Directions
Publisher: American Chemical Society (ACS)
Date: 19-04-2021
Inertial Microfluidic Purification of Floating Cancer Cells for Drug Screening and Three-Dimensional Tumor Models
Publisher: American Chemical Society (ACS)
Date: 25-06-2020
Controllable high-performance liquid marble micromixer
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2LC00017B
Abstract: A high-performance micromixer based on rolling liquid marble.
Protein array processing software for automated semiquantitative analysis of serum antibody repertoires
Publisher: AIP Publishing
Date: 09-2023
DOI: 10.1063/5.0169421
Recent Advances and Future Perspectives on Microfluidic Liquid Handling
Publisher: MDPI AG
Date: 12-06-2017
DOI: 10.3390/MI8060186
Dynamic behaviours of monodisperse double emulsion formation in a tri-axial capillary device
Publisher: Research Square Platform LLC
Date: 29-09-2022
DOI: 10.21203/RS.3.RS-2110258/V1
Abstract: We investigated experimentally, analytically and numerically the formation process of double emulsion formations under dripping regime in a tri-axial co-flow capillary device. The results show that mismatches of core and shell droplets under a given flow condition can be captured both experimentally and numerically. We propose a semi-analytical model using the match ratio between the pinch-off length of the shell droplet and the product of the core growth rate and its pinch-off time. The mismatch issue can be avoided if the match ratio is lower than unity. We considered a model with the wall effect to predict the size of the matched double emulsion. The model shows slight deviations with experimental data if the Reynolds number of continuous phase is lower than 0.06, but asymptotically approaches to good agreement if the Reynolds number increases from 0.06 to 0.14. The numerical simulation generally agrees with the experiments under various flow conditions.
Front Cover: Investigation of liquid marble shell using X‐ray: shell thickness and effective surface tension (ChemNanoMat 1/2022)
Publisher: Wiley
Date: 09-12-2022
Dynamic Behaviour of Monodisperse Double Emulsion Formation in a Tri-axial Capillary Device
Publisher: MDPI AG
Date: 14-10-2022
DOI: 10.20944/PREPRINTS202210.0213.V1
Abstract: We investigated experimentally, analytically and numerically the formation process of double emulsion formations under dripping regime in a tri-axial co-flow capillary device. The results show that mismatches of core and shell droplets under a given flow condition can be captured both experimentally and numerically. We propose a semi-analytical model using the match ratio between the pinch-off length of the shell droplet and the product of the core growth rate and its pinch-off time. The mismatch issue can be avoided if the match ratio is lower than unity. We considered a model with the wall effect to predict the size of the matched double emulsion. The model shows slight deviations with experimental data if the Reynolds number of continuous phase is lower than 0.06, but asymptotically approaches to good agreement if the Reynolds number increases from 0.06 to 0.14. The numerical simulation generally agrees with the experiments under various flow conditions.
The stress-strain relationship of liquid marbles under compression
Publisher: AIP Publishing
Date: 28-01-2019
DOI: 10.1063/1.5079438
Abstract: Liquid marbles can be characterized using elastic solid models consisting of a liquid surrounded by a soft solid membrane. The elastic properties of liquid marbles determine the amount of compression under a given external force. This is an important property as the elasticity of liquid marbles determines their morphology under a given stress. We show that the stress-strain relationship of liquid marbles can be described by σ*Bo=0.6[1/(1−εhro)2−1], where Bo is the Bond number, σ* is the normalised stress, and εhr0 is the strain measured with respect to the equivalent radius of the liquid marble. This stress-strain relationship could pave the way for the development of microfluidic devices with robust liquid marbles.
Accurate dielectrophoretic positioning of a floating liquid marble with a two-electrode configuration
Publisher: Springer Science and Business Media LLC
Date: 03-06-2019
Deformation of a floating liquid marble.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4SM02882A
Abstract: We report the analytical and experimental characterisation of the deformation of a liquid marble floating on a liquid surface.
Critical Trapping Conditions for Floating Liquid Marbles
Publisher: American Physical Society (APS)
Date: 02-01-2020
Core–Shell Particles: From Fabrication Methods to Diverse Manipulation Techniques
Publisher: MDPI AG
Date: 21-02-2023
DOI: 10.3390/MI14030497
Abstract: Core–shell particles are micro- or nanoparticles with solid, liquid, or gas cores encapsulated by protective solid shells. The unique composition of core and shell materials imparts smart properties on the particles. Core–shell particles are gaining increasing attention as tuneable and versatile carriers for pharmaceutical and biomedical applications including targeted drug delivery, controlled drug release, and biosensing. This review provides an overview of fabrication methods for core–shell particles followed by a brief discussion of their application and a detailed analysis of their manipulation including assembly, sorting, and triggered release. We compile current methodologies employed for manipulation of core–shell particles and demonstrate how existing methods of assembly and sorting micro/nanospheres can be adopted or modified for core–shell particles. Various triggered release approaches for diagnostics and drug delivery are also discussed in detail.
Coalescence processes of droplets and liquid marbles
Publisher: MDPI AG
Date: 20-11-2017
DOI: 10.3390/MI8110336
Core -Shell Particles: from Fabrication Methods to Diverse Manipulation Techniques
Publisher: MDPI AG
Date: 26-12-2022
DOI: 10.20944/PREPRINTS202212.0463.V1
Abstract: Core-shell particles are heterogenous micro- or nanoparticles with solid, liquid or gas core encapsulated by a protective solid shell. The unique composition of core and shell materials imparts smart properties to the particles. Core-shell particles are gaining increasing attention as tuneable and versatile carriers for pharmaceutical and biomedical applications including targeted drug delivery, controlled drug release, and biosensing. This review first provides an overview of fabrication methods for core-shell particles, followed by a brief discussion on their application and a detailed analysis on manipulation including assembly, sorting, and triggered release. We compile current methodologies employed for manipulation of core-shell particles and demonstrate how existing methods of assembly and sorting micro/nanospheres can be adopted or modified for core-shell particles. Various triggered release approaches for diagnostics and drug delivery are also discussed in detail.
Picking up and placing a liquid marble using dielectrophoresis
Publisher: Springer Science and Business Media LLC
Date: 21-11-2018
Biodegradable Polymers for Micro Elastofluidics
Publisher: Wiley
Date: 09-06-2023
Abstract: Micro elastofluidics is an emerging research field that encompasses characteristics of conventional microfluidics and fluid‐structure interactions. Micro elastofluidics is expected to enable practical applications, for instance, where direct contact between biological s les and fluid handling systems is required. Besides design optimization, choosing a proper material is critical to the practical use of micro elastofluidics upon interaction with biological interface and after its functional lifetime. Biodegradable polymers are one of the most studied materials for this purpose. Micro elastofluidic devices made of biodegradable polymers possess exceptional mechanical elasticity, excellent bio compatibility, and structural degradability into non‐toxic products. This article provides an insightful and systematic review of the utilization of biodegradable polymers in digital and continuous‐flow micro elastofluidics.
Liquid marbles as biochemical reactors for the polymerase chain reaction
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9LC00676A
Abstract: Liquid marbles can serve as a biochemical reactor for the polymerase chain reaction, eliminating the conventional single use plastic reaction vial.
Effect of Core Liquid Surface Tension on the Liquid Marble Shell
Publisher: Wiley
Date: 23-11-2020
Uniaxial Cyclic Cell Stretching Device for Accelerating Cellular Studies
Publisher: MDPI AG
Date: 05-07-2023
DOI: 10.20944/PREPRINTS202307.0263.V1
Abstract: Cellular response to mechanical stimuli is a crucial factor for maintaining cell homeostasis. The interaction between extracellular matrix and mechanical stress plays a significant role in organ-izing the cytoskeleton and aligning cells. Tools that apply mechanical forces to cells and tissues, as well as those capable of measuring the mechanical properties of biological cells, have greatly contributed to our understanding of fundamental mechanobiology. These tools have been exten-sively employed to unveil the substantial influence of mechanical cues on the development and progression of various diseases. In this report, we present an economical and high-performance uniaxial cell stretching device. This paper reports the detailed operation concept of the device, ex-perimental design, and characterization. The device was tested with MDA-MB-231 breast cancer cells. Experimental results agree well with previously documented morphological changes re-sulting from stretching forces on cancer cells. Remarkably, our new device demonstrates compa-rable cellular changes within a 30-minute compared to the previous 2-hour stretching duration. Moreover, the device design incorporates an open-source software interface, facilitating conven-ient parameter adjustments such as strain, stretching speed, frequency, and duration. Its versatil-ity enables seamless integration with various optical microscopes, thereby yielding novel insights into the realm of mechanobiology.
Related Organisations
Related Funding Activities
Discovery Projects - Grant ID: DP220100261
Start Date: 07-2022
End Date: 06-2025
Amount: $495,000.00
Funder: Australian Research Council
View Funded ActivityDiscovery Early Career Researcher Award - Grant ID: DE200100119
Start Date: 01-2020
End Date: 01-2023
Amount: $424,607.00
Funder: Australian Research Council
View Funded Activity