ORCID Profile
0000-0003-1169-5082
Current Organisations
University of Oxford
,
Newcastle University
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Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SC06844J
Abstract: mRNA display generates vast datasets of protein binders. Bioinformatic clustering of the sequences combined with high throughput synthesis and analysis methods allow efficient prioritisation of hits for in vivo experiments.
Publisher: Springer Science and Business Media LLC
Date: 23-09-2020
Publisher: Public Library of Science (PLoS)
Date: 06-07-2015
Publisher: Elsevier BV
Date: 05-2011
Publisher: American Chemical Society (ACS)
Date: 11-07-2012
DOI: 10.1021/JM300677J
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6OB02616H
Abstract: We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides.
Publisher: Informa UK Limited
Date: 07-03-2016
Publisher: Springer Science and Business Media LLC
Date: 05-03-2014
DOI: 10.1038/NCOMMS4423
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7SC02103H
Abstract: Four compounds in clinical trials for anaemia treatment are potent inhibitors of the hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs), but differ in potency and how they interact with HIF at the PHD active site.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC00286J
Abstract: Tight, non-active site binding cyclic peptides are promising affinity reagents for studying proteins and their interactions.
Publisher: Informa UK Limited
Date: 07-2020
Publisher: American Chemical Society (ACS)
Date: 09-07-2019
DOI: 10.1021/ACSCHEMBIO.9B00289
Abstract: Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are "epigenetic eraser" enzymes involved in the regulation of gene expression and are emerging drug targets in oncology. We screened a set of clinically used iron chelators and report that they potently inhibit JMJD2A (KDM4A)
Publisher: American Chemical Society (ACS)
Date: 04-01-2013
DOI: 10.1021/JM301583M
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC00387D
Abstract: The binding of prolyl-hydroxylated HIF-α to PHD2 is hindered by prior 2OG binding likely, leading to the inhibition of HIF-α degradation under limiting 2OG conditions.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Akane Kawamura.