ORCID Profile
0000-0001-7169-9961
Current Organisation
Tongji University
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Publisher: Wiley
Date: 07-10-2018
Publisher: Wiley
Date: 11-06-2019
Publisher: American Chemical Society (ACS)
Date: 16-08-2023
Publisher: Springer Science and Business Media LLC
Date: 22-08-2019
DOI: 10.1038/S41467-019-11762-0
Abstract: Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine. Here we eliminate the toxicity of amyloid beta (Aβ) in a facile, high-throughput zebrafish ( Danio rerio ) model using casein coated-gold nanoparticles (βCas AuNPs). βCas AuNPs in systemic circulation translocate across the blood brain barrier of zebrafish larvae and sequester intracerebral Aβ 42 and its elicited toxicity in a nonspecific, chaperone-like manner. This is evidenced by behavioral pathology, reactive oxygen species and neuronal dysfunction biomarkers assays, complemented by brain histology and inductively coupled plasma-mass spectroscopy. We further demonstrate the capacity of βCas AuNPs in recovering the mobility and cognitive function of adult zebrafish exposed to Aβ. This potent, safe-to-use, and easy-to-apply nanomedicine may find broad use for eradicating toxic amyloid proteins implicated in a range of human diseases.
Publisher: American Chemical Society (ACS)
Date: 08-08-2018
DOI: 10.1021/ACS.NANOLETT.8B02446
Abstract: Amyloid diseases are global epidemics with no cure available. Herein, we report a first demonstration of in vivo mitigation of amyloidogenesis using biomimetic nanotechnology. Specifically, the amyloid fragments (b
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR07180B
Abstract: Graphene quantum dots are biocompatible zero-dimensional nanostructures, which displayed a potency in rescuing zebrafish embryos from the toxicity of human islet amyloid polypeptide.
No related grants have been discovered for Guotao Peng.