ORCID Profile
0000-0002-4590-1334
Current Organisation
University of Liverpool
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: JMIR Publications Inc.
Date: 07-03-2019
Abstract: iarrheal disease, which affects 1 in 4 people in the United Kingdom annually, is the most common cause of outbreaks in community and health care settings. Traditional surveillance methods tend to detect point-source outbreaks of diarrhea and vomiting they are less effective at identifying low-level and intermittent food supply contamination. Furthermore, it can take up to 9 weeks for infections to be confirmed, reducing slow-burn outbreak recognition, potentially impacting hundreds or thousands of people over wide geographical areas. There is a need to address fundamental problems in traditional diarrheal disease surveillance because of underreporting and subsequent unconfirmed infection by patients and general practitioners (GPs) varying submission practices and selective testing of s les in laboratories limitations in traditional microbiological diagnostics, meaning that the timeliness of s le testing and etiology of most cases remains unknown and poorly integrated human and animal surveillance systems, meaning that identification of zoonoses is delayed or missed. his study aims to detect anomalous patterns in the incidence of gastrointestinal disease in the (human) community to target s ling to test traditional diagnostic methods against rapid, modern, and sensitive molecular and genomic microbiology methods that identify and characterize responsible pathogens rapidly and more completely and to determine the cost-effectiveness of rapid, modern, sensitive molecular and genomic microbiology methods. yndromic surveillance will be used to aid identification of anomalous patterns in microbiological events based on temporal associations, demographic similarities among patients and animals, and changes in trends in acute gastroenteritis cases using a point process statistical model. Stool s les will be obtained from patients’ consulting GPs, to improve the timeliness of cluster detection and characterize the pathogens responsible, allowing health protection professionals to investigate and control outbreaks quickly, limiting their size and impact. The cost-effectiveness of the proposed system will be examined using formal cost-utility analysis to inform decisions on national implementation. he project commenced on April 1, 2013. Favorable approval was obtained from the Research Ethics Committee on June 15, 2015, and the first patient was recruited on October 13, 2015, with 1407 patients recruited and s les processed using traditional laboratory techniques as of March 2017. he overall aim of this study is to create a new One Health paradigm for detecting and investigating diarrhea and vomiting in the community in near-real time, shifting from passive human surveillance and management of laboratory-confirmed infection toward an integrated, interdisciplinary enhanced surveillance system including management of people with symptoms. ERR1-10.2196/13941
Publisher: Elsevier BV
Date: 2019
Publisher: American Society for Microbiology
Date: 15-10-2012
DOI: 10.1128/JVI.00701-12
Abstract: Feline calicivirus (FCV) is an important pathogen of domestic cats and a frequently used model of human caliciviruses. Here we use an epidemiologically rigorous s ling framework to describe for the first time the phylodynamics of a calicivirus at regional and national scales. A large number of FCV strains cocirculated in the United Kingdom at the national and community levels, with no strain comprising more than 5% and 14% of these populations, respectively. The majority of strains exhibited a relatively restricted geographical range, with only two strains (one field virus and one vaccine virus) spreading further than 100 km. None of the field strains were identified outside the United Kingdom. Temporally, while some strains persisted locally for the majority of the study, others may have become locally extinct. Evolutionary analysis revealed a radial phylogeny with little bootstrap support for nodes above the strain level. In most cases, spatially and temporally erse strains intermingled in the phylogeny. Together, these data suggest that current FCV evolution is not associated with selective competition among strains. Rather, the genetic and antigenic landscape in each geographical location is highly complex, with many strains cocirculating. These variants likely exist at the community level by a combination of de novo evolution and occasional gene flow from the wider national population. This complexity provides a benchmark, for the first time, against which vaccine cross-protection at both local and national levels can be judged.
Publisher: Elsevier BV
Date: 04-2010
DOI: 10.1016/J.TVJL.2009.01.009
Abstract: C ylobacteriosis is a major cause of gastroenteritis in humans and some studies have suggested that dog ownership is a risk factor for the condition. To determine the prevalence, species distribution, and risk indicators for C ylobacter spp. infecting dogs attending veterinary practices in UK, faecal s les were collected in a cross-sectional study from 249 dogs with and without clinical signs. The prevalence of C ylobacter spp. was 38% (95% CI 32, 44), with C ylobacter upsaliensis accounting for 94 (98%) of the isolates and C ylobacter jejuni for the remainder. Multivariable analysis indicated that younger dogs were more likely to carry C. upsaliensis and the high prevalence of this pathogen supports the hypothesis that dogs, particularly younger animals, may be an important source of C. upsaliensis infection for humans. However the prevalence of C. jejuni, the most common C ylobacter spp. associated with disease in humans, was low (1.2%, 95% CI 0.3, 3).
Publisher: American Society for Microbiology
Date: 25-06-2015
Abstract: Leptospira interrogans serovar Bratislava infection occurs in multiple domestic and wildlife species and is associated with poor reproductive performance in swine and horses. We present the complete genome assembly of strain PigK151 comprising two chromosomes, CI (4.457 Mbp) and CII (358 kbp).
Publisher: Springer Science and Business Media LLC
Date: 2011
Publisher: Wiley
Date: 08-2019
DOI: 10.1136/VR.105075
Abstract: Clinical The high levels of resistance to polymyxin shown here, along with genetic similarities between some human and animal isolates, together suggest a need for sustained surveillance of this veterinary niche as a potential reservoir for resistant, clinically relevant bacteria in both animals and humans.
Publisher: University of Toronto Press Inc. (UTPress)
Date: 03-2006
DOI: 10.3138/JVME.33.1.38
Publisher: JMIR Publications Inc.
Date: 26-09-2019
DOI: 10.2196/13941
Abstract: Diarrheal disease, which affects 1 in 4 people in the United Kingdom annually, is the most common cause of outbreaks in community and health care settings. Traditional surveillance methods tend to detect point-source outbreaks of diarrhea and vomiting they are less effective at identifying low-level and intermittent food supply contamination. Furthermore, it can take up to 9 weeks for infections to be confirmed, reducing slow-burn outbreak recognition, potentially impacting hundreds or thousands of people over wide geographical areas. There is a need to address fundamental problems in traditional diarrheal disease surveillance because of underreporting and subsequent unconfirmed infection by patients and general practitioners (GPs) varying submission practices and selective testing of s les in laboratories limitations in traditional microbiological diagnostics, meaning that the timeliness of s le testing and etiology of most cases remains unknown and poorly integrated human and animal surveillance systems, meaning that identification of zoonoses is delayed or missed. This study aims to detect anomalous patterns in the incidence of gastrointestinal disease in the (human) community to target s ling to test traditional diagnostic methods against rapid, modern, and sensitive molecular and genomic microbiology methods that identify and characterize responsible pathogens rapidly and more completely and to determine the cost-effectiveness of rapid, modern, sensitive molecular and genomic microbiology methods. Syndromic surveillance will be used to aid identification of anomalous patterns in microbiological events based on temporal associations, demographic similarities among patients and animals, and changes in trends in acute gastroenteritis cases using a point process statistical model. Stool s les will be obtained from patients’ consulting GPs, to improve the timeliness of cluster detection and characterize the pathogens responsible, allowing health protection professionals to investigate and control outbreaks quickly, limiting their size and impact. The cost-effectiveness of the proposed system will be examined using formal cost-utility analysis to inform decisions on national implementation. The project commenced on April 1, 2013. Favorable approval was obtained from the Research Ethics Committee on June 15, 2015, and the first patient was recruited on October 13, 2015, with 1407 patients recruited and s les processed using traditional laboratory techniques as of March 2017. The overall aim of this study is to create a new One Health paradigm for detecting and investigating diarrhea and vomiting in the community in near-real time, shifting from passive human surveillance and management of laboratory-confirmed infection toward an integrated, interdisciplinary enhanced surveillance system including management of people with symptoms. DERR1-10.2196/13941
Publisher: Wiley
Date: 10-2016
DOI: 10.1136/VR.I5322
Abstract: Presentation for pruritus comprised 6.5 per cent, 3.6 per cent and 2.0 per cent of canine, feline and rabbit consultations, respectively, between January 2014 and June 2016Topical antimicrobials were the most commonly prescribed pruritus treatments for dogs (33.6 per cent of consultations) for cats, it was systemic glucocorticoids (53.5 per cent)In surveillance of coagulase-positive staphylococci, 16 per cent of 176 coagulase-positive staphylococci isolated from canine diagnostic s les were sensitive to all tested antibacterial classes multidrug resistance (resistance to three or more antibacterial classes) was found in 6.8 per cent.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Alan Radford.