ORCID Profile
0000-0002-5419-0909
Current Organisations
University of Melbourne
,
Landspítali University Hospital
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Quantum Physics | Optical Physics | Medical Devices | Interdisciplinary Engineering not elsewhere classified | Elemental Semiconductors | Interdisciplinary Engineering | Pharmaceutical Sciences | Medical Biotechnology not elsewhere classified | Quantum Optics | Surfaces and Structural Properties of Condensed Matter | Photonics, Optoelectronics and Optical Communications | Quantum Information, Computation and Communication | Degenerate Quantum Gases and Atom Optics | Quantum Physics not elsewhere classified |
ANZSRC Socio-Economic Objective (SEO)
Expanding Knowledge in the Physical Sciences | Scientific Instruments | Expanding Knowledge in Engineering | Human Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Medical and Health Sciences | Expanding Knowledge in Technology
Related Links
Publications
Magneto-optical imaging of thin magnetic films using spins in diamond
Publisher: Springer Science and Business Media LLC
Date: 14-03-2016
DOI: 10.1038/SREP22797
Abstract: Imaging the fields of magnetic materials provides crucial insight into the physical and chemical processes surrounding magnetism and has been a key ingredient in the spectacular development of magnetic data storage. Existing approaches using the magneto-optic Kerr effect, x-ray and electron microscopy have limitations that constrain further development and there is increasing demand for imaging and characterisation of magnetic phenomena in real time with high spatial resolution. Here we show how the magneto-optical response of an array of negatively-charged nitrogen-vacancy spins in diamond can be used to image and map the sub-micron stray magnetic field patterns from thin ferromagnetic films. Using optically detected magnetic resonance, we demonstrate wide-field magnetic imaging over 100 × 100 μm 2 with sub-micron spatial resolution at video frame rates, under ambient conditions. We demonstrate an all-optical spin relaxation contrast imaging approach which can image magnetic structures in the absence of an applied microwave field. Straightforward extensions promise imaging with sub-μT sensitivity and sub-optical spatial and millisecond temporal resolution. This work establishes practical diamond-based wide-field microscopy for rapid high-sensitivity characterisation and imaging of magnetic s les, with the capability for investigating magnetic phenomena such as domain wall and skyrmion dynamics and the spin Hall effect in metals.
Apparent delocalization of the current density in metallic wires observed with diamond nitrogen-vacancy magnetometry
Publisher: American Physical Society (APS)
Date: 29-01-2019
Recent progress in diamond photonics
Publisher: IEEE
Date: 07-2012
Energy transfer processes related to the S-band transition in Tm
Publisher: IEE
Date: 2005
DOI: 10.1049/CP:20050708
A highly efficient two level diamond based single photon source
Publisher: AIP Publishing
Date: 18-05-2009
DOI: 10.1063/1.3141450
Abstract: An unexplored diamond defect center that is found to emit stable single photons at a measured rate of 1.6 MHz at room temperature is reported. The center, identified in chemical vapor deposition grown diamond crystals, exhibits a sharp zero phonon line at 734 nm with a full width at half maximum of ∼4 nm. The photon statistics confirm that the center is a single emitter and provides direct evidence of a true two level single quantum system in diamond.
Visible and near infra-red up-conversion in Tm^3+/Yb^3+ co-doped silica fibers under 980 nm excitation
Publisher: The Optical Society
Date: 21-08-2008
DOI: 10.1364/OE.16.013781
Abstract: The spectroscopic properties of Tm(3+)/Yb(3+) co-doped silica fibers under excitation at 980 nm are reported. Three distinct up-conversion fluorescence bands were observed in the visible to near infra-red regions. The blue and red fluorescence bands at 475 and 650 nm, respectively, were found to originate from the (1)G(4) level of Tm(3+). A three step up-conversion process was established as the populating mechanism for these fluorescence bands. The fluorescence band at 800 nm was found to originate from two possible transitions in Tm(3+) one being the transition from the (3)H(4) to (3)H(6) manifold which was found to dominate at low pump powers the other being the transition from the (1)G(4) to (3)H(6) level which dominates at higher pump powers. The fluorescence lifetime of the (3)H(4) and (3)F(4) levels of Tm(3+) and (2)F(5/2) level of Yb(3+) were studied as a function of Yb(3+) concentration, with no significant energy back transfer from Tm(3+) to Yb(3+) observed.
Quantum measurement and orientation tracking of fluorescent nanodiamonds inside living cells
Publisher: Springer Science and Business Media LLC
Date: 08-05-2011
Abstract: Fluorescent particles are routinely used to probe biological processes. The quantum properties of single spins within fluorescent particles have been explored in the field of nanoscale magnetometry, but not yet in biological environments. Here, we demonstrate optically detected magnetic resonance of in idual fluorescent nanodiamond nitrogen-vacancy centres inside living human HeLa cells, and measure their location, orientation, spin levels and spin coherence times with nanoscale precision. Quantum coherence was measured through Rabi and spin-echo sequences over long (>10 h) periods, and orientation was tracked with effective 1° angular precision over acquisition times of 89 ms. The quantum spin levels served as fingerprints, allowing in idual centres with identical fluorescence to be identified and tracked simultaneously. Furthermore, monitoring decoherence rates in response to changes in the local environment may provide new information about intracellular processes. The experiments reported here demonstrate the viability of controlled single spin probes for nanomagnetometry in biological systems, opening up a host of new possibilities for quantum-based imaging in the life sciences.
Non-Neurotoxic Nanodiamond Probes for Intraneuronal Temperature Mapping
Publisher: American Chemical Society (ACS)
Date: 13-11-2017
Abstract: Optical biomarkers have been used extensively for intracellular imaging with high spatial and temporal resolution. Extending the modality of these probes is a key driver in cell biology. In recent years, the nitrogen-vacancy (NV) center in nanodiamond has emerged as a promising candidate for bioimaging and biosensing with low cytotoxicity and stable photoluminescence. Here we study the electrophysiological effects of this quantum probe in primary cortical neurons. Multielectrode array recordings across five replicate studies showed no statistically significant difference in 25 network parameters when nanodiamonds are added at varying concentrations over various time periods, 12-36 h. The physiological validation motivates the second part of the study, which demonstrates how the quantum properties of these biomarkers can be used to report intracellular information beyond their location and movement. Using the optically detected magnetic resonance from the nitrogen-vacancy defects within the nanodiamonds we demonstrate enhanced signal-to-noise imaging and temperature mapping from thousands of nanodiamond probes simultaneously. This work establishes nanodiamonds as viable multifunctional intraneuronal sensors with nanoscale resolution, which may ultimately be used to detect magnetic and electrical activity at the membrane level in excitable cellular systems.
Quantum measurement in living cells: Fluorescent diamond nanocrystals for biology
Publisher: IEEE
Date: 08-2011
Scanning Nanospin Ensemble Microscope for Nanoscale Magnetic and Thermal Imaging
Publisher: American Chemical Society (ACS)
Date: 04-01-2016
DOI: 10.1021/ACS.NANOLETT.5B03877
Abstract: Quantum sensors based on solid-state spins provide tremendous opportunities in a wide range of fields from basic physics and chemistry to biomedical imaging. However, integrating them into a scanning probe microscope to enable practical, nanoscale quantum imaging is a highly challenging task. Recently, the use of single spins in diamond in conjunction with atomic force microscopy techniques has allowed significant progress toward this goal, but generalization of this approach has so far been impeded by long acquisition times or by the absence of simultaneous topographic information. Here, we report on a scanning quantum probe microscope which solves both issues by employing a nanospin ensemble hosted in a nanodiamond. This approach provides up to an order of magnitude gain in acquisition time while preserving sub-100 nm spatial resolution both for the quantum sensor and topographic images. We demonstrate two applications of this microscope. We first image nanoscale clusters of maghemite particles through both spin resonance spectroscopy and spin relaxometry, under ambient conditions. Our images reveal fast magnetic field fluctuations in addition to a static component, indicating the presence of both superparamagnetic and ferromagnetic particles. We next demonstrate a new imaging modality where the nanospin ensemble is used as a thermometer. We use this technique to map the photoinduced heating generated by laser irradiation of a single gold nanoparticle in a fluid environment. This work paves the way toward new applications of quantum probe microscopy such as thermal/magnetic imaging of operating microelectronic devices and magnetic detection of ion channels in cell membranes.
<title>Characterization of a thulium-doped silica-based optical fibre for S-band amplification</title>
Publisher: SPIE
Date: 07-02-2006
DOI: 10.1117/12.675682
Fluorescent Nanodiamond Silk Fibroin Spheres: Advanced Nanoscale Bioimaging Tool
Publisher: American Chemical Society (ACS)
Date: 25-09-2015
Quantum Sensing in a Physiological‐Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers
Publisher: Wiley
Date: 22-04-2019
Abstract: Fluorescent nanodiamonds (fNDs) containing nitrogen vacancy (NV) centers are promising candidates for quantum sensing in biological environments. This work describes the fabrication and implementation of electrospun poly lactic-co-glycolic acid (PLGA) nanofibers embedded with fNDs for optical quantum sensing in an environment, which recapitulates the nanoscale architecture and topography of the cell niche. A protocol that produces uniformly dispersed fNDs within electrospun nanofibers is demonstrated and the resulting fibers are characterized using fluorescent microscopy and scanning electron microscopy (SEM). Optically detected magnetic resonance (ODMR) and longitudinal spin relaxometry results for fNDs and embedded fNDs are compared. A new approach for fast detection of time varying magnetic fields external to the fND embedded nanofibers is demonstrated. ODMR spectra are successfully acquired from a culture of live differentiated neural stem cells functioning as a connected neural network grown on fND embedded nanofibers. This work advances the current state of the art in quantum sensing by providing a versatile sensing platform that can be tailored to produce physiological-like cell niches to replicate biologically relevant growth environments and fast measurement protocols for the detection of co-ordinated endogenous signals from clinically relevant populations of electrically active neuronal circuits.
Quantum magnetic imaging of iron organelles within the pigeon cochlea
Publisher: Proceedings of the National Academy of Sciences
Date: 15-11-2021
Abstract: Cuticulosomes are subcellular structures located within the inner ear hair cells of a variety of avian species with potential relevance to magnetoreception. Here we apply quantum magnetic microscopy to image the magnetic properties of in idual iron cuticulosomes within tissue s les. The magnetic susceptibility of the cuticulosomes was determined by characterizing the stray magnetic field strength as a function of applied magnetic field in two distinct locations of the pigeon inner ear. The measured susceptibilities do not support the particle model of magnetoreception, suggesting the physiological relevance of cuticulosomes lies in iron storage or stabilization of stereocilia. The quantum magnetic imaging method can be applied across a variety of biological systems providing an effective tool to screen for magnetic particle–based magnetoreceptors.
Electronic Properties and Metrology Applications of the DiamondNV
Publisher:
American Physical Society (APS)
Date:
31-01-2014
Publisher: American Physical Society (APS)
Date: 31-01-2014
Quantum imaging of current flow in graphene
Publisher: American Association for the Advancement of Science (AAAS)
Date: 07-04-2017
Abstract: We demonstrate diamond-based quantum imaging of the current flow in graphene structures with submicrometer resolution.
Diamond for neural interfacing: A review
Publisher: Elsevier BV
Date: 06-2016
Anticrossing Spin Dynamics of Diamond Nitrogen-Vacancy Centers and All-Optical Low-Frequency Magnetometry
Publisher: American Physical Society (APS)
Date: 02-12-2016
Room temperature single photon emission from zinc oxide nanoparticles formed by ion implantation in silica
Publisher: IEEE
Date: 06-2013
Microwave-free nuclear magnetic resonance at molecular scales
Publisher: Springer Science and Business Media LLC
Date: 03-07-2017
DOI: 10.1038/NCOMMS15950
Abstract: The implementation of nuclear magnetic resonance (NMR) at the nanoscale is a major challenge, as the resolution of conventional methods is limited to mesoscopic scales. Approaches based on quantum spin probes, such as the nitrogen-vacancy (NV) centre in diamond, have achieved nano-NMR under ambient conditions. However, the measurement protocols require application of complex microwave pulse sequences of high precision and relatively high power, placing limitations on the design and scalability of these techniques. Here we demonstrate NMR on a nanoscale organic environment of proton spins using the NV centre while eliminating the need for microwave manipulation of either the NV or the environmental spin states. We also show that the sensitivity of our significantly simplified approach matches that of existing techniques using the NV centre. Removing the requirement for coherent manipulation while maintaining measurement sensitivity represents a significant step towards the development of robust, non-invasive nanoscale NMR probes.
Two-Level Ultrabright Single Photon Emission from Diamond Nanocrystals
Publisher: American Chemical Society (ACS)
Date: 11-08-2009
DOI: 10.1021/NL9014167
Abstract: The fabrication of stable ultrabright single photon sources operating at room temperature is reported. The emitter is based on a color center within a diamond nanocrystal grown on a sapphire substrate by chemical vapor deposition method and exhibits a two-level electronic behavior with a maximum measured count rate of 3.2 x 10(6) counts/s at saturation. The emission is centered at approximately 756 nm with a full width at half-maximum approximately 11 nm and an excited state lifetime of 3.7 ns. These unique properties make it a leading candidate for quantum photonics and communication applications as well as for cellular biomarking.
Towards single-molecule NMR detection and spectroscopy using single spins in diamond
Publisher: American Physical Society (APS)
Date: 27-02-2014
Magnetically sensitive nanodiamond-doped tellurite glass fibers
Publisher: Springer Science and Business Media LLC
Date: 19-01-2018
DOI: 10.1038/S41598-018-19400-3
Abstract: Traditional optical fibers are insensitive to magnetic fields, however many applications would benefit from fiber-based magnetometry devices. In this work, we demonstrate a magnetically sensitive optical fiber by doping nanodiamonds containing nitrogen vacancy centers into tellurite glass fibers. The fabrication process provides a robust and isolated sensing platform as the magnetic sensors are fixed in the tellurite glass matrix. Using optically detected magnetic resonance from the doped nanodiamonds, we demonstrate detection of local magnetic fields via side excitation and longitudinal collection. This is a first step towards intrinsically magneto-sensitive fiber devices with future applications in medical magneto-endoscopy and remote mineral exploration sensing.
In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos
Publisher: The Optical Society
Date: 20-03-2014
DOI: 10.1364/BOE.5.001250
Quantum probe hyperpolarisation of molecular nuclear spins
Publisher: Springer Science and Business Media LLC
Date: 28-03-2018
DOI: 10.1038/S41467-018-03578-1
Abstract: Hyperpolarisation of nuclear spins is important in overcoming sensitivity and resolution limitations of magnetic resonance imaging and nuclear magnetic resonance spectroscopy. Current hyperpolarisation techniques require high magnetic fields, low temperatures, or catalysts. Alternatively, the emergence of room temperature spin qubits has opened new pathways to achieve direct nuclear spin hyperpolarisation. Employing a microwave-free cross-relaxation induced polarisation protocol applied to a nitrogen vacancy qubit, we demonstrate quantum probe hyperpolarisation of external molecular nuclear spins to ~50% under ambient conditions, showing a single qubit increasing the polarisation of ~10 6 nuclear spins by six orders of magnitude over the thermal background. Results are verified against a detailed theoretical treatment, which also describes how the system can be scaled up to a universal quantum hyperpolarisation platform for macroscopic s les. Our results demonstrate the prospects for this approach to nuclear spin hyperpolarisation for molecular imaging and spectroscopy and its potential to extend beyond into other scientific areas.
Nano-manipulation of diamond-based single photon sources
Publisher: Optica Publishing Group
Date: 22-06-2009
DOI: 10.1364/OE.17.011287
Abstract: The ability to manipulate nano-particles at the nano-scale is critical for the development of active quantum systems. This paper presents a technique to manipulate diamond nano-crystals at the nano-scale using a scanning electron microscope, nano-manipulator and custom tapered optical fibre probes. The manipulation of a approximately 300 nm diamond crystal, containing a single nitrogen-vacancy centre, onto the endface of an optical fibre is demonstrated. The emission properties of the single photon source post manipulation are in excellent agreement with those observed on the original substrate.
High spatial and temporal resolution wide-field imaging of neuron activity using quantum NV-diamond
Publisher: Springer Science and Business Media LLC
Date: 09-05-2012
DOI: 10.1038/SREP00401
Acoustomicrofluidic Concentration and Signal Enhancement of Fluorescent Nanodiamond Sensors
Publisher: American Chemical Society (ACS)
Date: 23-11-2021
DOI: 10.1021/ACS.ANALCHEM.1C03893
Abstract: Diamond nitrogen-vacancy (NV) centers constitute a promising class of quantum nanosensors owing to the unique magneto-optic properties associated with their spin states. The large surface area and photostability of diamond nanoparticles, together with their relatively low synthesis costs, make them a suitable platform for the detection of biologically relevant quantities such as paramagnetic ions and molecules in solution. Nevertheless, their sensing performance in solution is often h ered by poor signal-to-noise ratios and long acquisition times due to distribution inhomogeneities throughout the analyte s le. By concentrating the diamond nanoparticles through an intense microcentrifugation effect in an acoustomicrofluidic device, we show that the resultant dense NV ensembles within the diamond nanoparticles give rise to an order-of-magnitude improvement in the measured acquisition time. The ability to concentrate nanoparticles under surface acoustic wave (SAW) microcentrifugation in a sessile droplet is, in itself, surprising given the well-documented challenge of achieving such an effect for particles below 1 μm in dimension. In addition to a demonstration of their sensing performance, we thus reveal in this work that the reason why the diamond nanoparticles readily concentrate under the SAW-driven recirculatory flow can be attributed to their considerably higher density and hence larger acoustic contrast compared to those for typical particles and cells for which the SAW microcentrifugation flow has been shown to date.
Enhanced single-photon emission in the near infrared from a diamond color center
Publisher: American Physical Society (APS)
Date: 15-06-2009
Near-Surface Spectrally Stable Nitrogen Vacancy Centres Engineered in Single Crystal Diamond
Publisher: Wiley
Date: 25-05-2012
Abstract: A method for engineering thin (<100 nm) layers of homoepitaxial diamond containing high quality, spectrally stable, isolated nitrogen-vacancy (NV) centres is reported. The photoluminescence excitation linewidth of the engineered NVs are as low as 140 MHz, at temperatures below 12 K, while the spin properties are at a level suitable for quantum memory and spin register applications. This methodology of NV fabrication is an important step toward scalable and practical diamond based photonic devices suitable for quantum information processing.
Advances in the Surface Functionalization of Nanodiamonds for Biological Applications: A Review
Publisher: American Chemical Society (ACS)
Date: 04-10-2021
Fluorescent diamond microparticle doped glass fiber for magnetic field sensing
Publisher: AIP Publishing
Date: 08-2020
DOI: 10.1063/5.0013473
Abstract: Diamond containing the nitrogen-vacancy (NV) center is emerging as a significant sensing platform. However, most NV sensors require microscopes to collect the fluorescence signals and therefore are limited to laboratory settings. By embedding micron-scale diamond particles at an annular interface within the cross section of a silicate glass fiber, we demonstrate a robust fiber material capable of sensing magnetic fields. Luminescence spectroscopy and electron spin resonance characterization reveal that the optical properties of NV centers in the diamond microcrystals are well preserved throughout the fiber drawing process. The hybrid fiber presents a low propagation loss of ∼4.0 dB/m in the NV emission spectral window, permitting remote monitoring of the optically detected magnetic resonance signals. We demonstrate NV-spin magnetic resonance readout through 50 cm of fiber. This study paves a way for the scalable fabrication of fiber-based diamond sensors for field-deployable quantum metrology applications.
Fluorescent nanoparticles for biosensing applications
Publisher: IEEE
Date: 06-2013
Manipulating the Quantum Coherence of Optically Trapped Nanodiamonds
Publisher: American Chemical Society (ACS)
Date: 10-2018
Impact of Surface Functionalization on the Quantum Coherence of Nitrogen-Vacancy Centers in Nanodiamonds
Publisher: American Chemical Society (ACS)
Date: 20-03-2018
Abstract: Nanoscale quantum probes such as the nitrogen-vacancy (NV) center in diamonds have demonstrated remarkable sensing capabilities over the past decade as control over fabrication and manipulation of these systems has evolved. The biocompatibility and rich surface chemistry of diamonds has added to the utility of these probes but, as the size of these nanoscale systems is reduced, the surface chemistry of diamond begins to impact the quantum properties of the NV center. In this work, we systematically study the effect of the diamond surface chemistry on the quantum coherence of the NV center in nanodiamonds (NDs) 50 nm in size. Our results show that a borane-reduced diamond surface can on average double the spin relaxation time of in idual NV centers in nanodiamonds when compared to thermally oxidized surfaces. Using a combination of infrared and X-ray absorption spectroscopy techniques, we correlate the changes in quantum relaxation rates with the conversion of sp
Engineering of nitrogen-vacancy color centers in high purity diamond by ion implantation and annealing
Publisher: AIP Publishing
Date: 15-04-2011
DOI: 10.1063/1.3573768
Abstract: The negatively-charged nitrogen-vacancy (NV) center is the most studied optical center in diamond and is very important for applications in quantum information science. Many proposals for integrating NV centers in quantum and sensing applications rely on their tailored fabrication in ultra pure host material. In this study, we use ion implantation to controllably introduce nitrogen into high purity, low nitrogen chemical vapor deposition diamond s les. The properties of the resulting NV centers are studied as a function of implantation temperature, annealing temperature, and implantation fluence. We compare the implanted NV centers with native NV centers present deep in the bulk of the as-grown s les. The results for implanted NV centers are promising but indicate, at this stage, that the deep native NV centers possess overall superior optical properties. In particular, the implanted NV centers obtained after annealing at 2000 °C under a stabilizing pressure of 8 GPa showed an ensemble linewidth of 0.17 nm compared to 0.61 nm after annealing at 1000 °C. Over the same temperature range, the ensemble NV−/NV0 ratio increased by a factor of ∼5, although this was accompanied by an overall decrease in the NV count.
A diamond voltage imaging microscope
Publisher: Springer Science and Business Media LLC
Date: 08-09-2022
Towards all-diamond optical devices
Publisher: IEEE
Date: 06-2010
Nanoscale sensing and imaging in biology using the nitrogen-vacancy center in diamond
Publisher: Springer Science and Business Media LLC
Date: 02-2013
DOI: 10.1557/MRS.2013.24
Detection of nanoscale electron spin resonance spectra demonstrated using nitrogen-vacancy centre probes in diamond
Publisher: Springer Science and Business Media LLC
Date: 05-01-2016
DOI: 10.1038/NCOMMS10211
Abstract: Electron spin resonance (ESR) describes a suite of techniques for characterizing electronic systems with applications in physics, chemistry, and biology. However, the requirement for large electron spin ensembles in conventional ESR techniques limits their spatial resolution. Here we present a method for measuring ESR spectra of nanoscale electronic environments by measuring the longitudinal relaxation time of a single-spin probe as it is systematically tuned into resonance with the target electronic system. As a proof of concept, we extracted the spectral distribution for the P1 electronic spin bath in diamond by using an ensemble of nitrogen-vacancy centres, and demonstrated excellent agreement with theoretical expectations. As the response of each nitrogen-vacancy spin in this experiment is dominated by a single P1 spin at a mean distance of 2.7 nm, the application of this technique to the single nitrogen-vacancy case will enable nanoscale ESR spectroscopy of atomic and molecular spin systems.
Electrospun Nanodiamond-Silk Fibroin Membranes: A Multifunctional Platform for Biosensing and Wound-Healing Applications
Publisher: American Chemical Society (ACS)
Date: 13-10-2020
Photophysics of chromium-related diamond single-photon emitters
Publisher: American Physical Society (APS)
Date: 13-04-2010
Ambient nanoscale sensing with single spins using quantum decoherence
Publisher: IOP Publishing
Date: 23-07-2013
Diamond-based single-photon emitters
Publisher: IOP Publishing
Date: 14-06-2011
MPCVD Processing of Titanium-diffused LiNbO<inf>3</inf> Waveguides: Optical Characterisation and Waveguide Restoration
Publisher: IEEE
Date: 12-2006
Estimation of energy transfer parameters in thulium- and ytterbium-doped silica fibers
Publisher: SPIE
Date: 17-11-2008
DOI: 10.1117/12.818042
Rapid, High‐Resolution Magnetic Microscopy of Single Magnetic Microbeads
Publisher: Wiley
Date: 26-03-2019
Abstract: Magnetic microparticles or "beads" are used in a variety of research applications from cell sorting through to optical force traction microscopy. The magnetic properties of such particles can be tailored for specific applications with the uniformity of in idual beads critical to their function. However, the majority of magnetic characterization techniques quantify the magnetic properties from large bead ensembles. Developing new magnetic imaging techniques to evaluate and visualize the magnetic fields from single beads will allow detailed insight into the magnetic uniformity, anisotropy, and alignment of magnetic domains. Here, diamond-based magnetic microscopy is applied to image and characterize in idual magnetic beads with varying magnetic and structural properties: ferromagnetic and superparamagnetic aramagnetic, shell (coated with magnetic material), and solid (magnetic material dispersed in matrix). The single-bead magnetic images identify irregularities in the magnetic profiles from in idual bead populations. Magnetic simulations account for the varying magnetic profiles and allow to infer the magnetization of in idual beads. Additionally, this work shows that the imaging technique can be adapted to achieve illumination-free tracking of magnetic beads, opening the possibility of tracking cell movements and mechanics in photosensitive contexts.
Environmentally Mediated Coherent Control of a Spin Qubit in Diamond
Publisher: American Physical Society (APS)
Date: 19-04-2017
An integrated widefield probe for practical diamond nitrogen-vacancy microscopy
Publisher: AIP Publishing
Date: 20-12-2021
DOI: 10.1063/5.0073320
Abstract: The widefield diamond nitrogen-vacancy (NV) microscope is a powerful instrument for imaging magnetic fields. However, a key limitation impeding its wider adoption is its complex operation, in part due to the difficulty of precisely interfacing the sensor and s le to achieve optimum spatial resolution. Here, we demonstrate a solution to this interfacing problem that is practical and reliably minimizes NV-s le standoff. We built a compact widefield NV microscope, which incorporates an integrated widefield diamond probe with full position and angular control, and developed a systematic alignment procedure based on optical interference fringes. Using this platform, we imaged an ultrathin (1 nm) magnetic film test s le and conducted a detailed study of the spatial resolution. We reproducibly achieved an estimated NV-s le standoff (and hence spatial resolution) of at most ∼2 μm across a ∼0.5 mm field of view. Guided by these results, we suggest future improvements for approaching the optical diffraction limit. This work is a step toward realizing a widefield NV microscope suitable for routine high-throughput mapping of magnetic fields.
Chromium single-photon emitters in diamond fabricated by ion implantation
Publisher: American Physical Society (APS)
Date: 15-03-2010
Wide-band nanoscale magnetic resonance spectroscopy using quantum relaxation of a single spin in diamond
Publisher: American Physical Society (APS)
Date: 05-10-2016
Energy transfer up-conversion in Tm3+-doped silica fiber
Publisher: Elsevier BV
Date: 02-2006
Infrared induced photo-dynamics of NV centres in optically trapped nanodiamond
Publisher: SPIE
Date: 07-09-2018
DOI: 10.1117/12.2320821
Tm<sup>3+</sup>/Yb<sup>3+</sup> co-doped alumino-silicate fibre: potential for S-band optical amplification
Publisher: IEEE
Date: 06-2007
Diamond waveguides: toward an all-diamond platform
Publisher: SPIE
Date: 21-12-2007
DOI: 10.1117/12.769906
Proximity-Induced Artefacts in Magnetic Imaging with Nitrogen-Vacancy Ensembles in Diamond
Publisher: MDPI AG
Date: 23-04-2018
DOI: 10.3390/S18041290
Comparison of different methods of nitrogen-vacancy layer formation in diamond for wide-field quantum microscopy
Publisher: American Physical Society (APS)
Date: 29-10-2020
Quantum Magnetic Imaging of Iron Biomineralization in Teeth of the Chiton Acanthopleura hirtosa
Publisher: Wiley
Date: 19-01-2020
21^st-Century Applications of Nanodiamonds
Publisher: The Optical Society
Date: 09-2010
Dynamic Stabilization of the Optical Resonances of Single Nitrogen-Vacancy Centers in Diamond
Publisher: American Physical Society (APS)
Date: 14-05-2012
Room-temperature single-photon emission from zinc oxide nanoparticle defects and their in vitro photostable intrinsic fluorescence
Publisher: Walter de Gruyter GmbH
Date: 25-06-2016
Abstract: Zinc oxide (ZnO) is a promising semiconductor that is suitable for bioimaging applications due to its intrinsic defect fluorescence. However, ZnO generally suffers from poor photostability. We report room-temperature single-photon emission from optical defects found in ZnO nanoparticles (NPs) formed by ion implantation followed by thermal oxidation in a silica substrate. We conduct a thorough investigation into the photophysics of a particularly bright defect and identify other single emitters within the NPs. Photostability was observed when the NPs were removed from the growth substrate and taken up by skin cells for in vitro imaging.
Re-examining ferritin-bound iron: current and developing clinical tools
Publisher: Walter de Gruyter GmbH
Date: 22-10-2020
Abstract: Iron is a highly important metal ion cofactor within the human body, necessary for haemoglobin synthesis, and required by a wide range of enzymes for essential metabolic processes. Iron deficiency and overload both pose significant health concerns and are relatively common world-wide health hazards. Effective measurement of total iron stores is a primary tool for both identifying abnormal iron levels and tracking changes in clinical settings. Population based data is also essential for tracking nutritional trends. This review article provides an overview of the strengths and limitations associated with current techniques for diagnosing iron status, which sets a basis to discuss the potential of a new serum marker – ferritin-bound iron – and the improvement it could offer to iron assessment.
Nonmonotonic Superparamagnetic Behavior of the Ferritin Iron Core Revealed via Quantum Spin Relaxometry
Publisher: American Chemical Society (ACS)
Date: 19-12-2022
Optimizing Optical Tweezers Experiments for Magnetic Resonance Sensing with Nanodiamonds
Publisher: American Chemical Society (ACS)
Date: 15-03-2021
Electron paramagnetic resonance microscopy using spins in diamond under ambient conditions
Publisher: Springer Science and Business Media LLC
Date: 06-09-2017
Nanomechanical Sensing Using Spins in Diamond
Publisher: American Chemical Society (ACS)
Date: 13-02-2017
DOI: 10.1021/ACS.NANOLETT.6B04544
Abstract: Nanomechanical sensors and quantum nanosensors are two rapidly developing technologies that have erse interdisciplinary applications in biological and chemical analysis and microscopy. For ex le, nanomechanical sensors based upon nanoelectromechanical systems (NEMS) have demonstrated chip-scale mass spectrometry capable of detecting single macromolecules, such as proteins. Quantum nanosensors based upon electron spins of negatively charged nitrogen-vacancy (NV) centers in diamond have demonstrated erse modes of nanometrology, including single molecule magnetic resonance spectroscopy. Here, we report the first step toward combining these two complementary technologies in the form of diamond nanomechanical structures containing NV centers. We establish the principles for nanomechanical sensing using such nanospin-mechanical sensors (NSMS) and assess their potential for mass spectrometry and force microscopy. We predict that NSMS are able to provide unprecedented AC force images of cellular biomechanics and to not only detect the mass of a single macromolecule but also image its distribution. When combined with the other nanometrology modes of the NV center, NSMS potentially offer unparalleled analytical power at the nanoscale.
Processing of Diamond: Towards All-Diamond Integrated Optics
Publisher: IEEE
Date: 06-2007
Intrinsic fluorescence of selenium nanoparticles for cellular imaging applications
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NR08771F
Abstract: (a) Microscopic image of selenium nanoparticles uptaken by the fibroblast cells. (b) Intrinsic fluorescence of the particles exploited for in vitro imaging.
Modelling strain dependence of fluorescence from doped optical fibres: application to neodymium
Publisher: IEEE
Date: 2002
Quantum probes for biology: Unlocking single molecule dynamics
Publisher: Elsevier BV
Date: 02-2019
Not All Fluorescent Nanodiamonds Are Created Equal: A Comparative Study
Publisher: Wiley
Date: 28-01-2019
Magnetic noise from ultrathin abrasively deposited materials on diamond
Publisher: American Physical Society (APS)
Date: 08-11-2018
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Publisher: Springer Science and Business Media LLC
Date: 03-2023
Spin properties of dense near-surface ensembles of nitrogen-vacancy centers in diamond
Publisher: American Physical Society (APS)
Date: 02-02-2018
Detection of atomic spin labels in a lipid bilayer using a single-spin nanodiamond probe
Publisher: Proceedings of the National Academy of Sciences
Date: 17-06-2013
Abstract: Magnetic field fluctuations arising from fundamental spins are ubiquitous in nanoscale biology, and are a rich source of information about the processes that generate them. However, the ability to detect the few spins involved without averaging over large ensembles has remained elusive. Here, we demonstrate the detection of gadolinium spin labels in an artificial cell membrane under ambient conditions using a single-spin nanodiamond sensor. Changes in the spin relaxation time of the sensor located in the lipid bilayer were optically detected and found to be sensitive to near-in idual (4 ± 2) proximal gadolinium atomic labels. The detection of such small numbers of spins in a model biological setting, with projected detection times of 1 s [corresponding to a sensitivity of ∼5 Gd spins per Hz 1/2 ], opens a pathway for in situ nanoscale detection of dynamical processes in biology.
A diamond voltage imaging microscope
Publisher: Research Square Platform LLC
Date: 11-05-2022
DOI: 10.21203/RS.3.RS-1102242/V1
Abstract: Technologies that capture the complex electrical dynamics occurring in biological systems, across fluid membranes and at solid-liquid interfaces drive fundamental understanding and innovation in erse fields from neuroscience to energy storage. However, the capabilities of existing voltage imaging techniques utilizing micro-electrode arrays, scanning probes, or optical fluorescence methods are respectively limited by resolution, scan speed, and photostability. Here we develop an optoelectronic voltage imaging system which overcomes these limitations by using charge-sensitive fluorescent reporters embedded within a transparent semiconducting diamond device. Electrochemical tuning of the diamond surface termination enables photostable optical voltage imaging with a quantitative linear response at biologically relevant voltages and timescales. This technology represents a major step toward label-free, large-scale, and long-term voltage recording of physical and biological systems with sub-micron resolution.
Temperature and angle dependent magnetic imaging of biological iron nanoparticles using quantum diamond microscopy
Publisher: AIP Publishing
Date: 16-01-2023
DOI: 10.1063/5.0114998
Abstract: Quantum diamond microscopy is an emerging versatile technique for studying the magnetic properties of materials. It has been applied extensively in condensed matter physics and materials science and has blossomed into a unique platform for the magnetic study of biological systems. To date, biological demonstrations of quantum diamond microscopy have been performed under ambient conditions. Here, we extend this magnetic microscopy platform to cryogenic temperatures to study magnetic anisotropy and the blocking temperature from an in idual iron organelle found within the inner ear of pigeons. Our work confirms that the interface between thin histological tissue sections and diamond can be maintained under cryogenic temperatures. Our magnetic images provide evidence of magnetic anisotropy from a single iron organelle with sub-cellular resolution using this correlative optical imaging method. This approach may be extended to a broad range of systems where magnetic materials play structural and functional roles in biological systems.
Microscopic Imaging of the Stress Tensor in Diamond Using in Situ Quantum Sensors
Publisher: American Chemical Society (ACS)
Date: 31-05-2019
DOI: 10.1021/ACS.NANOLETT.9B01402
Abstract: The precise measurement of mechanical stress at the nanoscale is of fundamental and technological importance. In principle, all six independent variables of the stress tensor, which describe the direction and magnitude of compression/tension and shear stress in a solid, can be exploited to tune or enhance the properties of materials and devices. However, existing techniques to probe the local stress are generally incapable of measuring the entire stress tensor. Here, we make use of an ensemble of atomic-sized in situ strain sensors in diamond (nitrogen-vacancy defects) to achieve spatial mapping of the full stress tensor, with a submicrometer spatial resolution and a sensitivity of the order of 1 MPa (10 MPa) for the shear (axial) stress components. To illustrate the effectiveness and versatility of the technique, we apply it to a broad range of experimental situations, including mapping the stress induced by localized implantation damage, nanoindents, and scratches. In addition, we observe surprisingly large stress contributions from functional electronic devices fabricated on the diamond and also demonstrate sensitivity to deformations of materials in contact with the diamond. Our technique could enable in situ measurements of the mechanical response of diamond nanostructures under various stimuli, with potential applications in strain engineering for diamond-based quantum technologies and in nanomechanical sensing for on-chip mass spectroscopy.
Reactive ion etching of waveguide structures in diamond
Publisher: Elsevier BV
Date: 11-2008
Enhanced Widefield Quantum Sensing with Nitrogen-Vacancy Ensembles Using Diamond Nanopillar Arrays
Publisher: American Chemical Society (ACS)
Date: 26-02-2020
Creation of nitrogen-vacancy centers in chemical vapor deposition diamond for sensing applications
Publisher: IOP Publishing
Date: 03-2022
Abstract: The nitrogen-vacancy (NV) center in diamond is a promising quantum system for magnetometry applications exhibiting optical readout of minute energy shifts in its spin sub-levels. Key material requirements for NV ensembles are a high NV − concentration, a long spin coherence time and a stable charge state. However, these are interdependent and can be difficult to optimize during diamond growth and subsequent NV creation. In this work, we systematically investigate the NV center formation and properties in bulk chemical vapor deposition (CVD) diamond. The nitrogen flow during growth is varied by over four orders of magnitude, resulting in a broad range of single substitutional nitrogen concentrations of 0.2–20 parts per million. For a fixed nitrogen concentration, we optimize electron-irradiation fluences with two different accelerated electron energies, and we study defect formation via optical characterizations. We discuss a general approach to determine the optimal irradiation conditions, for which an enhanced NV concentration and an optimum of NV charge states can both be satisfied. We achieve spin–spin coherence times T 2 ranging from 45.5 to 549 μ s for CVD diamonds containing 168 to 1 parts per billion NV − centers, respectively. This study shows a pathway to engineer properties of NV-doped CVD diamonds for improved sensitivity.
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