ORCID Profile
0000-0002-8245-6778
Current Organisation
Monash University - Caulfield Campus
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Publisher: Wiley
Date: 14-05-2017
DOI: 10.1111/ACPS.12742
Abstract: There is some evidence that clozapine is significantly underutilised. Also, clozapine use is thought to vary by country, but so far no international study has assessed trends in clozapine prescribing. Therefore, this study aimed to assess clozapine use trends on an international scale, using standardised criteria for data analysis. A repeated cross‐sectional design was applied to data extracts (2005–2014) from 17 countries worldwide. In 2014, overall clozapine use prevalence was greatest in Finland (189.2/100 000 persons) and in New Zealand (116.3/100 000), and lowest in the Japanese cohort (0.6/100 000), and in the privately insured US cohort (14.0/100 000). From 2005 to 2014, clozapine use increased in almost all studied countries (relative increase: 7.8–197.2%). In most countries, clozapine use was highest in 40–59‐year‐olds (range: 0.6/100 000 (Japan) to 344.8/100 000 (Finland)). In youths (10–19 years), clozapine use was highest in Finland (24.7/100 000) and in the publicly insured US cohort (15.5/100 000). While clozapine use has increased in most studied countries over recent years, clozapine is still underutilised in many countries, with clozapine utilisation patterns differing significantly between countries. Future research should address the implementation of interventions designed to facilitate increased clozapine utilisation.
Publisher: Elsevier BV
Date: 2020
DOI: 10.2139/SSRN.3588074
Publisher: Springer International Publishing
Date: 2021
Publisher: Springer International Publishing
Date: 2022
Publisher: Elsevier BV
Date: 10-2017
DOI: 10.1016/J.EURONEURO.2017.07.001
Abstract: The objective of this study was to assess international trends in antipsychotic use, using a standardised methodology. A repeated cross-sectional design was applied to data extracts from the years 2005 to 2014 from 16 countries worldwide. During the study period, the overall prevalence of antipsychotic use increased in 10 of the 16 studied countries. In 2014, the overall prevalence of antipsychotic use was highest in Taiwan (78.2/1000 persons), and lowest in Colombia (3.2/1000). In children and adolescents (0-19 years), antipsychotic use ranged from 0.5/1000 (Lithuania) to 30.8/1000 (Taiwan). In adults (20-64 years), the range was 2.8/1000 (Colombia) to 78.9/1000 (publicly insured US population), and in older adults (65+ years), antipsychotic use ranged from 19.0/1000 (Colombia) to 149.0/1000 (Taiwan). Atypical antipsychotic use increased in all populations (range of atypical/typical ratio: 0.7 (Taiwan) to 6.1 (New Zealand, Australia)). Quetiapine, risperidone, and olanzapine were most frequently prescribed. Prevalence and patterns of antipsychotic use varied markedly between countries. In the majority of populations, antipsychotic utilisation and especially the use of atypical antipsychotics increased over time. The high rates of antipsychotic prescriptions in older adults and in youths in some countries merit further investigation and systematic pharmacoepidemiologic monitoring.
Publisher: Elsevier BV
Date: 2020
DOI: 10.2139/SSRN.3712947
Publisher: Springer Nature Switzerland
Date: 2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2022
Publisher: ACM
Date: 15-07-2023
Publisher: Wiley
Date: 12-2014
DOI: 10.1111/GEC3.12185
Publisher: ACM
Date: 20-07-2016
Publisher: Springer International Publishing
Date: 27-12-2016
No related grants have been discovered for Camilo Cruz Gambardella.