ORCID Profile
0000-0002-7832-0413
Current Organisations
Université Laval
,
French Institute of Health and Medical Research
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Publisher: Oxford University Press (OUP)
Date: 25-11-2008
DOI: 10.1093/AJE/KWN333
Publisher: CMA Joule Inc.
Date: 30-09-2013
DOI: 10.1503/CMAJ.122010
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 04-2010
DOI: 10.1161/HYPERTENSIONAHA.109.144220
Abstract: Records of repeated examinations of blood pressure are increasingly available for primary care patients, but the use of this information in predicting incident hypertension remains unclear, because cohort studies with repeat blood pressure monitoring are rare. We compared the incremental value of using data on blood pressure history to a single measure as in the Framingham hypertension risk score, a validated hypertension risk prediction algorithm. Participants were 4314 London-based civil servants (1297 women) aged 35 to 68 years who were free from prevalent hypertension, diabetes mellitus, and coronary heart disease at baseline examination (the Whitehall II Study). Standard clinical examinations of blood pressure, weight and height, current cigarette smoking, and parental history of hypertension were undertaken on a 5-year basis. A total of 1052 incident (new-onset) cases of hypertension were observed in two 5-year baseline follow-up data cycles. Comparison of the Framingham risk score with a score additionally incorporating 5-year blood pressure history showed, at best, modest improvements in indicators of predictive performance: C statistics (0.796 versus 0.799), predicted:observed ratios (1.04 [95% CI: 0.95 to 1.15] versus 0.98 [95% CI: 0.89 to 1.08]), or Hosmer-Lemeshow χ 2 values (11.5 versus 6.5). The net reclassification improvement with the modified score was 9.3% (95% CI: 4.2% to 14.4%), resulting from a net 17.1% increase in nonhypertensives correctly identified as being at lower risk but a net 7.8% increase in hypertensives incorrectly identified as at lower risk. These data suggest that, despite the net reclassification improvement, the clinical use of adding repeat measures of blood pressure to the Framingham hypertension risk score may be limited.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2008
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 07-2008
DOI: 10.1161/ATVBAHA.108.167239
Abstract: Objectives— The purpose of this study was to test whether psychological factors affect inflammation processes to an extent that increases the risk of coronary heart disease (CHD). Methods and Results— We used data from 6396 civil servants (4453 men, 1943 women) from the Whitehall II Study, aged 35 to 55 years and free from clinically validated CHD at the start of the follow-up period. Two psychological factors were assessed at phase 1 (1985 to 1988) and phase 2 (1989 to 1990): negative affect and psychological distress. Inflammatory biomarkers (fibrinogen, high-sensitivity C-reactive- protein, interleukin-6) and 12 baseline covariates including biological and behavioral CHD risk factors, sociodemographic variables, and work stress were measured at phase 3 (1991 to 1993). Follow-up for CHD death, first nonfatal myocardial infarction, or definite angina occurring between phase 3 and phase 7 (2003 to 2004) was based on clinical records. Higher levels of inflammatory markers were associated with higher CHD incidence, with hazard ratios (HR) ranging from 1.31 to 2.37 in age-and sex-adjusted models. Higher levels of negative affectivity and psychological distress were not associated with greater concentrations of inflammatory markers. Negative affectivity (relative index of inequality=1.68, 95% confidence interval [CI] 1.20 to 2.36) and higher psychological distress exposure (HR=1.66, 95% CI 1.28 to 2.14) were associated with higher CHD incidence and these associations remained unchanged after adjustment for inflammatory markers. Conclusions— Our findings suggest that psychological factors do not affect inflammation although they predict incident CHD.
Publisher: Royal College of Psychiatrists
Date: 08-2009
DOI: 10.1192/BJP.BP.108.057299
Abstract: Prospective data on the association between common mental disorders and obesity are scarce, and the impact of ageing on this association is poorly understood. To examine the association between common mental disorders and obesity (body mass index 30 kg/m 2 ) across the adult life course. The participants, 6820 men and 3346 women, aged 35–55 were screened four times during a 19-year follow-up (the Whitehall II study). Each screening included measurements of mental disorders (the General Health Questionnaire), weight and height. The excess risk of obesity in the presence of mental disorders increased with age ( P = 0.004). The estimated proportion of people who were obese was 5.7% at age 40 both in the presence and absence of mental disorders, but the corresponding figures were 34.6% and 27.1% at age 70. The excess risk did not vary by gender or according to ethnic group or socioeconomic position. The association between common mental disorders and obesity becomes stronger at older ages.
Publisher: Oxford University Press (OUP)
Date: 14-02-2008
DOI: 10.1093/IJE/DYN021
Publisher: BMJ
Date: 15-09-2010
Publisher: Wiley
Date: 02-07-2020
DOI: 10.1111/DME.14345
Publisher: BMJ
Date: 06-10-2009
DOI: 10.1136/BMJ.B3765
Publisher: Elsevier BV
Date: 12-2016
DOI: 10.1016/J.PSYNEUEN.2016.08.020
Abstract: To examine longitudinal associations between antidepressant medication use and the metabolic syndrome (MetS). 5014 participants (49.8% were men) from the D.E.S.I.R. cohort study, aged 30-65 years at baseline in 1994-1996, were followed over 9 years at 3-yearly intervals (1997-1999, 2000-2002, and 2003-2005). Antidepressant use and MetS, defined by the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP-ATP III) and the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, were assessed concurrently at four medical examinations. In fully-adjusted longitudinal logistic regression analyses based on generalized estimating equations, antidepressant users had a 9% (p=0.011) and a 6% (p=0.036) greater annual increase in the odds of having the MetS defined by NCEP-ATP III and AHA/NHLBI criteria respectively. Sex-specific analyses showed that this association was confined to men only. When the different types of antidepressant were considered, men who used selective serotonin reuptake inhibitors (SSRIs), imipramine type antidepressants or "other" antidepressants had a 52% (p=0.028), 31% (p=0.011), and 16% (p=0.016) greater annual increase in the odds of having the MetS over time compared to non-users, respectively. These associations depended on the definition of the MetS. Our longitudinal data showed that antidepressant use was associated with an increased odds of having the MetS in men but not in women and this was mainly for SSRIs, imipramine type and "other" antidepressants. People on antidepressants may need to be checked regularly for the elements of the metabolic syndrome treatable by change in diet, physical activity and/or by medication therapy.
Publisher: Oxford University Press (OUP)
Date: 02-07-2009
DOI: 10.1093/AJE/KWP161
Publisher: BMJ
Date: 30-06-2008
DOI: 10.1136/BMJ.A118
Publisher: Oxford University Press (OUP)
Date: 09-07-2008
Publisher: Cambridge University Press (CUP)
Date: 17-07-2424
DOI: 10.1017/S0033291709990432
Abstract: The psychosocial vulnerability model of hostility posits that hostile in iduals, given their oppositional attitudes and behaviours, are more likely to have increased interpersonal conflicts, lower social support, more stressful life events (SL-E) and higher likelihood of depression. However, little research has tested this hypothesis using large-scale prospective s les. The present study aims to assess the predictive value of hostility for depressive mood. Data are from 3399 participants in the Whitehall II cohort study, aged 35–55 years at baseline (phase 1 1985–1988). Cynical hostility was measured at phase 1. Depressive mood was assessed at phase 7 (2002–2004). Sociodemographic characteristics, health-related behaviours, common mental disorders and antidepressant medication intake were assessed at phase 1. SL-E and confiding/emotional support were measured at phases 1, 2 (1989–1990) and 5 (1997–1999). Compared with participants in the lowest quartile of cynical hostility, those in the highest quartiles were more likely to have depressive mood [second quartile: odds ratio (OR) 1.58, 95% confidence interval (CI) 1.14–2.20 third quartile: OR 2.78, 95% CI 2.03–3.77 fourth quartile: OR 4.66, 95% CI 3.41–6.36] in analysis adjusted for sociodemographic characteristics. This graded association was somewhat attenuated (⩽18%) but remained robust to adjustments for the covariates measured at baseline and follow-up. The association was also evident in participants free of mental health difficulties at baseline. Cynical hostility is a strong and robust predictor of depressive mood. Consideration of personality characteristics may be crucial to the understanding and management of depression.
Publisher: Physicians Postgraduate Press, Inc
Date: 14-12-2010
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 04-2011
DOI: 10.1161/HYPERTENSIONAHA.110.164061
Abstract: Prospective data on depressive symptoms and blood pressure are scarce, and the impact of age on this association is poorly understood. The present study examines longitudinal trajectories of depressive episodes and the probability of hypertension associated with these trajectories over time. Participants were 6889 men and 3413 women, London-based civil servants aged 35 to 55 years at baseline, followed for 24 years between 1985 and 2009. Depressive episode (defined as scoring ≥4 on the General Health Questionnaire-Depression subscale or using prescribed antidepressant medication) and hypertension (systolic/diastolic blood pressure ≥140/90 mm Hg or use of antihypertensive medication) were assessed concurrently at 5 medical examinations. In the fully adjusted longitudinal logistic regression analyses based on generalized estimating equations using age as the time scale, participants in the “increasing depression” group had a 24% ( P .05) lower risk of hypertension at ages 35 to 39 years compared with those in the “low/transient depression” group. However, there was a faster age-related increase in hypertension in the increasing depression group, corresponding with a 7% ( P .01) greater increase in the odds of hypertension for each 5-year increase in age. A higher risk of hypertension in the first group of participants was not evident before 55 years of age. A similar pattern of association was observed in men and women, although it was stronger in men. This study suggests that the risk of hypertension increases with repeated experience of depressive episodes over time and becomes evident in later adulthood.
Location: No location found
Location: Saudi Arabia
No related grants have been discovered for Hermann Nabi.