ORCID Profile
0000-0002-2248-8700
Current Organisation
National University of Singapore
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Publisher: Springer Science and Business Media LLC
Date: 26-04-2018
DOI: 10.1007/S41114-018-0012-9
Abstract: We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals, and study the capability of the network to determine the sky location of the source. We report our findings for gravitational-wave transients, with particular focus on gravitational-wave signals from the inspiral of binary neutron star systems, which are the most promising targets for multi-messenger astronomy. The ability to localize the sources of the detected signals depends on the geographical distribution of the detectors and their relative sensitivity, and $$90\\%$$ 90 % credible regions can be as large as thousands of square degrees when only two sensitive detectors are operational. Determining the sky position of a significant fraction of detected signals to areas of 5– $$20~\\mathrm {deg}^2$$ 20 deg 2 requires at least three detectors of sensitivity within a factor of $$\\sim 2$$ ∼ 2 of each other and with a broad frequency bandwidth. When all detectors, including KAGRA and the third LIGO detector in India, reach design sensitivity, a significant fraction of gravitational-wave signals will be localized to a few square degrees by gravitational-wave observations alone.
Publisher: American Physical Society (APS)
Date: 08-10-2024
Publisher: American Physical Society (APS)
Date: 04-09-2019
Publisher: Springer Science and Business Media LLC
Date: 29-07-2019
DOI: 10.1038/S41598-019-47360-9
Abstract: We have studied differentially regulated nuclear proteome of the clinical tissue specimens of glioblastoma (GBM, WHO Grade IV) and lower grades of gliomas (Grade II and III) using high resolution mass spectrometry- based quantitative proteomics approach. The results showed altered expression of many regulatory proteins from the nucleus such as DNA binding proteins, transcription and post transcriptional processing factors and also included enrichment of nuclear proteins that are targets of granzyme signaling – an immune surveillance pathway. Protein - protein interaction network analysis using integrated proteomics and transcriptomics data of transcription factors and proteins for cell invasion process (drawn from another GBM dataset) revealed YBX1, a ubiquitous RNA and DNA-binding protein and a transcription factor, as a key interactor of major cell invasion-associated proteins from GBM. To verify the regulatory link between them, the co-expression of YBX1 and six of the interacting proteins (EGFR, MAPK1, CD44, SOX2, TNC and MMP13) involved in cell invasion network was examined by immunohistochemistry on tissue micro arrays. Our analysis suggests YBX1 as a potential regulator of these key molecules involved in tumor invasion and thus as a promising target for development of new therapeutic strategies for GBM.
Publisher: SAGE Publications
Date: 03-09-2010
Abstract: The hot deformation behavior of extruded Mg/nano-Al 2 O 3 composite has been studied in the temperature and strain rate ranges of 300-500°C and 0.0003-10 s -1 . In the lower strain rate regime ( .1 s -1 ), the apparent activation energy evaluated is much higher than that for lattice self-diffusion. At higher strain rates, the behavior of the composite is similar to that of the matrix material and is controlled by grain boundary self diffusion. The prior particle boundaries in the composite, which are decorated by the nano-alumina particles, are stable and only kink under compression parallel to the extrusion direction.
Publisher: Informa UK Limited
Date: 23-03-2015
Publisher: ASTM International
Date: 05-2019
DOI: 10.1520/MPC20190005
Publisher: American Astronomical Society
Date: 04-09-2019
Publisher: AIP Publishing
Date: 07-10-2019
DOI: 10.1063/1.5110383
Abstract: The fingerprint spectral response of several materials with terahertz electromagnetic radiation indicates that terahertz technology is an effective tool for sensing applications. However, sensing few nanometer thin-films of dielectrics with much longer terahertz waves (1 THz = 0.3 mm) is challenging. Here, we demonstrate a quasibound state in the continuum (BIC) resonance for sensing of a nanometer scale thin analyte deposited on a flexible metasurface. The large sensitivity originates from the strong local field confinement of the quasi-BIC Fano resonance state and extremely low absorption loss of a low-index cyclic olefin copolymer substrate. A minimum thickness of 7 nm thin-film of germanium is sensed on the metasurface, which corresponds to a deep subwavelength scale of λ/43 000, where λ is the resonance wavelength. The low-loss, flexible, and large mechanical strength of the quasi-BIC microstructured metamaterial sensor could be an ideal platform for developing ultrasensitive wearable terahertz sensors.
Publisher: American Astronomical Society
Date: 11-09-2019
Publisher: Elsevier BV
Date: 05-2006
Publisher: Elsevier BV
Date: 04-2007
Publisher: MDPI AG
Date: 08-06-2018
DOI: 10.3390/MET8060437
Publisher: Elsevier BV
Date: 09-2015
Publisher: American Physical Society (APS)
Date: 04-09-2019
Publisher: Elsevier BV
Date: 2014
Publisher: Elsevier BV
Date: 2013
Publisher: Springer Science and Business Media LLC
Date: 02-10-2008
Publisher: MDPI AG
Date: 05-09-2018
DOI: 10.3390/MET8090699
Abstract: AZ31-based nanocomposites are produced by disintegrated melt deposition (DMD) processing. In this investigation, the influence of the addition of Ca to AZ31-1.5 vol.% nano-alumina composite (base) on its hot working behavior is studied to develop a processing route for manufacturing components with these composites. A processing map for the base composite in the temperature range 250–500 °C and strain rate 0.0003–10 s−1 is compared with those for composites with 1% Ca and 2% Ca. The grain size of the base composite is refined by Ca addition and the 1 ¯ 0 texture is strengthened. Besides nano-alumina particles, the Ca-containing composites have intermetallic particles (Mg,Al)2Ca present at grain boundaries as well as in the matrix. All the three nanocomposites exhibit three DRX domains, with one of them at high strain rate that facilitates high productivity. Addition of Ca mitigates the occurrence of wedge cracking that occurs in AZ31-1.5NAl composite. Increasing of Ca addition to 2% prevents dynamic recrystallization (DRX) at lower temperatures and strain rates and causes only dynamic recovery. At lower temperatures and higher strain rates, DRX occurs by basal + prismatic slip along with recovery via climb controlled by grain boundary self-diffusion promoted by very fine grain size in the composites.
Publisher: Elsevier BV
Date: 12-2014
Publisher: American Physical Society (APS)
Date: 04-12-2019
Publisher: Elsevier BV
Date: 06-2009
Publisher: American Physical Society (APS)
Date: 20-11-2019
Publisher: MDPI AG
Date: 27-07-2020
Abstract: Mg-3Zn-1Al (AZ31) alloy is a popular wrought alloy, and its mechanical properties could be further enhanced by the addition of calcium (Ca). The formation of stable secondary phase (Mg,Al)2Ca enhances the creep resistance at the expense of formability and, therefore, necessitates the establishment of safe working window(s) for producing wrought products. In this study, AZ31-3Ca alloy has been prepared by the disintegrated melt deposition (DMD) processing route, and its hot deformation mechanisms have been evaluated, and compared with similarly processed AZ31, AZ31-1Ca and AZ31-2Ca magnesium alloys. DMD processing has refined the grain size to 2–3 μm. A processing map has been developed for the temperature range 300–450 °C and strain rate range 0.0003–10 s−1. Three working domains are established in which dynamic recrystallization (DRX) readily occurs, although the underlying mechanisms of DRX differ from each other. The alloy exhibits flow instability at lower temperatures and higher strain rates, which manifests as adiabatic shear bands. A comparison of the processing maps of these alloys revealed that the hot deformation mechanisms have not changed significantly by the increase of Ca addition.
Publisher: American Astronomical Society
Date: 26-06-2019
No related grants have been discovered for Manoj Gupta.