ORCID Profile
0000-0001-6026-8971
Current Organisations
University of Ulster at Jordanstown
,
University of Ulster
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Publisher: Elsevier BV
Date: 03-2023
Publisher: Elsevier BV
Date: 2012
Publisher: Elsevier BV
Date: 09-2009
Publisher: BMJ
Date: 06-2021
DOI: 10.1136/BMJOPEN-2020-048142
Abstract: To evaluate the dynamics and longevity of the humoral immune response to SARS-CoV-2 infection and assess the performance of professional use of the UK-RTC AbC-19 Rapid Test lateral flow immunoassay (LFIA) for the target condition of SARS-CoV-2 spike protein IgG antibodies. Nationwide serological study. Northern Ireland, UK, May 2020–February 2021. Plasma s les were collected from a erse cohort of in iduals from the general public (n=279), Northern Ireland healthcare workers (n=195), pre-pandemic blood donations and research studies (n=223) and through a convalescent plasma programme (n=183). Plasma donors (n=101) were followed with sequential s les over 11 months post-symptom onset. SARS-CoV-2 antibody levels in plasma s les using Roche Elecsys Anti-SARS-CoV-2 IgG/IgA/IgM, Abbott SARS-CoV-2 IgG and EuroImmun IgG SARS-CoV-2 ELISA immunoassays over time. UK-RTC AbC-19 LFIA sensitivity and specificity, estimated using a three-reference standard system to establish a characterised panel of 330 positive and 488 negative SARS-CoV-2 IgG s les. We detected persistence of SARS-CoV-2 IgG antibodies for up to 10 months post-infection, across a minimum of two laboratory immunoassays. On the known positive cohort, the UK-RTC AbC-19 LFIA showed a sensitivity of 97.58% (95.28% to 98.95%) and on known negatives, showed specificity of 99.59% (98.53 % to 99.95%). Through comprehensive analysis of a cohort of pre-pandemic and pandemic in iduals, we show detectable levels of IgG antibodies, lasting over 46 weeks when assessed by EuroImmun ELISA, providing insight to antibody levels at later time points post-infection. We show good laboratory validation performance metrics for the AbC-19 rapid test for SARS-CoV-2 spike protein IgG antibody detection in a laboratory-based setting.
Publisher: American Scientific Publishers
Date: 07-2009
DOI: 10.1166/JNN.2009.M82
Abstract: We report the growth of vertically oriented carbon micro-cones without using any foreign catalyst on silicon (100) substrate by microwave plasma assisted chemical vapour deposition method. The average height and bottom diameter of the carbon micro-cones are approximately 20 microm and approximately 1.4 microm, respectively. The diameters of the carbon micro-cones decrease gradually from bottom to tip, terminating in a nanotube structure. Mechanical damage of micro-cones resulted in the breaking and partial removal of the carbon micro-cones to show the structures possessed a nanotube core. Outside the micro-cone, the nanotubes showed a flattened ribbon structure. Electron microscopy and micro-Raman spectroscopy shows the nanotubes are multi walled and highly graphitic, with low structural disorder. The advanced vacuum electron emission devices could be fabricated with the carbon micro-cones grown directly on silicon substrate without using any catalyst.
Publisher: PeerJ
Date: 25-02-2021
DOI: 10.7717/PEERJ.10992
Abstract: The coronavirus (COVID-19) outbreak started in December 2019 and rapidly spread around the world affecting millions of people. With the growth of infection rate, many countries adopted different policies to control the spread of the disease. The UK implemented strict rules instructing in iduals to stay at home except in some special circumstances starting from 23 March 2020. Accordingly, this study focuses on sensitivity analysis of transmissibility of the infection as the effects of removing restrictions, for ex le by returning different occupational groups to their normal working environment and its effect on the reproduction number in the UK. For this reason, available social contact matrices are adopted for the population of UK to account for the average number of contacts. Different scenarios are then considered to analyse the variability of total contacts on the reproduction number in the UK as a whole and each of its four nations. Our data-driven retrospective analysis shows that if more than 38.5% of UK working-age population return to their normal working environment, the reproduction number in the UK is expected to be higher than 1. However, analysis of each nation, separately, shows that local reproduction number in each nation may be different and requires more adequate analysis. Accordingly, we believe that using statistical methods and historical data can provide good estimation of local transmissibility and reproduction number in any region. As a consequence of this analysis, efforts to reduce the restrictions should be implemented locally via different control policies. It is important that these policies consider the social contacts, population density, and the occupational groups that are specific to each region.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Publisher: Elsevier BV
Date: 09-2020
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for James McLaughlin.