ORCID Profile
0000-0002-9101-9131
Current Organisations
University of Milan
,
European Institute of Oncology
,
IRCCS European Institute of Oncology (IEO)
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Publications
Lack of PRKD 2 and PRKD 3 kinase domain somatic mutations in PRKD 1 wild‐type classic polymorphous low‐grade adenocarcinomas of the salivary gland
Publisher: Wiley
Date: 04-01-2016
DOI: 10.1111/HIS.12883
Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer
Publisher: Elsevier BV
Date: 11-2016
Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases
Publisher: Impact Journals, LLC
Date: 17-04-2018
MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB–NFIB fusion gene
Publisher: Wiley
Date: 28-12-2017
DOI: 10.1002/PATH.5006
The Genomic Landscape of Male Breast Cancers
Publisher: American Association for Cancer Research (AACR)
Date: 14-08-2016
DOI: 10.1158/1078-0432.CCR-15-2840
Abstract: Purpose: Male breast cancer is rare, and its genomic landscape has yet to be fully characterized. Lacking studies in men, treatment of males with breast cancer is extrapolated from results in females with breast cancer. We sought to define whether male breast cancers harbor somatic genetic alterations in genes frequently altered in female breast cancers. Experimental Design: All male breast cancers were estrogen receptor–positive, and all but two were HER2-negative. Fifty-nine male breast cancers were subtyped by immunohistochemistry, and tumor–normal pairs were microdissected and subjected to massively parallel sequencing targeting all exons of 241 genes frequently mutated in female breast cancers or DNA-repair related. The repertoires of somatic mutations and copy number alterations of male breast cancers were compared with that of subtype-matched female breast cancers. Results: Twenty-nine percent and 71% of male breast cancers were immunohistochemically classified as luminal A–like or luminal B–like, respectively. Male breast cancers displayed a heterogeneous repertoire of somatic genetic alterations that to some extent recapitulated that of estrogen receptor (ER)-positive/HER2-negative female breast cancers, including recurrent mutations affecting PIK3CA (20%) and GATA3 (15%). ER-positive/HER2-negative male breast cancers, however, less frequently harbored 16q losses, and PIK3CA and TP53 mutations than ER-positive/HER2-negative female breast cancers. In addition, male breast cancers were found to be significantly enriched for mutations affecting DNA repair–related genes. Conclusions: Male breast cancers less frequently harbor somatic genetic alterations typical of ER-positive/HER2-negative female breast cancers, such as PIK3CA and TP53 mutations and losses of 16q, suggesting that at least a subset of male breast cancers are driven by a distinct repertoire of somatic changes. Given the genomic differences, caution may be needed in the application of biologic and therapeutic findings from studies of female breast cancers to male breast cancers. Clin Cancer Res 22(16) 4045–56. ©2016 AACR.
The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis‐generating study
Publisher: Wiley
Date: 29-07-2015
DOI: 10.1002/PATH.4566
Microglandular adenosis associated with triple‐negative breast cancer is a neoplastic lesion of triple‐negative phenotype harbouring TP53 somatic mutations
Publisher: Wiley
Date: 17-03-2016
DOI: 10.1002/PATH.4691
Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing
Publisher: Wiley
Date: 29-06-2015
DOI: 10.1111/HIS.12735
MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast
Publisher: Wiley
Date: 24-05-2015
DOI: 10.1111/HIS.12712
Related Organisations
Università Degli Studi Del Piemonte Orientale Amedeo Avogadro
Location: Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Location: Italy
Memorial Sloan Kettering Cancer Center
Location: United States of America
Related Funding Activities
No related grants have been discovered for Nicola Fusco.