ORCID Profile
0000-0002-4072-4324
Current Organisations
Uppsala University
,
Uppsala Universitet
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: MDPI AG
Date: 21-09-2022
DOI: 10.3390/MOLECULES27196188
Abstract: An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent evaporation method. Crystallization of celecoxib was suppressed, and no reaction with the carrier was detected. The MMC formulation was evaluated in vitro and in vivo in terms of oral bioavailability. Celebra®, a commercially available formulation, was used as a reference. The two celecoxib formulations were orally administrated in male rats (average of n = 6 animals per group), and blood s les for plasma were taken from all animals at different time points after administration. There was no statistical difference (p 0.05) in AUCinf between the two formulations. The results showed that MMC may be a promising drug delivery excipient for increasing the bioavailability of compounds with solubility-limited absorption.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CC03180G
Abstract: Bismuth subgallate was revealed as a coordination polymer providing insight into its solubility and gas sorption properties.
Publisher: Elsevier BV
Date: 08-2016
Publisher: MDPI AG
Date: 06-05-2020
DOI: 10.3390/PHARMACEUTICS12050426
Abstract: Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC carrier via physical adsorption. A modified in vitro lipolysis setup was then used to study lipid release and digestion with 1H nuclear magnetic resonance spectroscopy. The lipid loading efficiency with different solidification techniques was also evaluated. The MMC, unlike more commonly used porous silicate carriers, dissolved during the lipolysis assay, providing a rapid release of encapsulated lipids into solution. The digestion of the dispersed lipid-loaded MMC therefore resembled that of a coarse dispersion of the lipid. The stability data demonstrated minor degradation of the lipid within the pores of the MMC particles, but storage for three months did not reveal extensive degradation. To conclude, lipids can be adsorbed onto MMC, creating a solid powder from which the lipid is readily released into the solution during in vitro digestion. The chemical stability of the formulation does however merit further attention.
Publisher: American Chemical Society (ACS)
Date: 21-04-2020
DOI: 10.1021/JACS.0C02984
Publisher: American Chemical Society (ACS)
Date: 03-12-2019
Publisher: Wiley
Date: 29-11-2010
Abstract: The pressure-swing adsorption method for carbon dioxide capture would ideally be facilitated by adsorbents with a high capacity and a high selectivity for CO₂. Several aluminophosphates with 8-ring window apertures (AlPO₄-17, AlPO₄-18, AlPO₄-53, and AlPO₄-25) were synthesized by hydrothermal crystallization, calcined, and their CO₂ uptake and CO₂/N₂ selectivity were studied. CO₂ and N₂ uptake was determined for pressures up to 101 kPa at 273 and 293 K. Langmuir and Toth adsorption models were used to describe the adsorption isotherms. The CO₂ and N₂ uptakes strongly indicated that the squeezed 8-ring windows of certain aluminophosphates can sieve CO₂ from a CO₂ and N₂ gas mixture. Both AlPO₄-53 and AlPO₄-25 exhibited a remarkably higher uptake of CO₂ compared to N₂. The hydrophilicity of the AlPO₄ materials was investigated by means of water adsorption, and the results showed that all of the tested aluminophosphates were less water sensitive than a benchmark zeolite (13X). In particular, AlPO₄-53 and AlPO₄-25 showed a very low degree of water uptake with up to 20-30 % relative humidity. Determination of cyclic adsorption and desorption confirmed the relatively hydrophobic nature of the aluminophosphates, which render them less energy costly for the regeneration of adsorbents.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Ocean Cheung.