ORCID Profile
0000-0001-8848-6399
Current Organisations
Asda Pharmacy
,
University of Bristol School of Social and Community Medicine
,
University of Bristol
,
M J Williams Ltd
,
University of Bath
,
Brigham and Women's Hospital
,
Harvard Medical School
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Publications
Coordinate Network Mapping: An Emerging Approach for Morphometric Meta-Analysis
Publisher: American Psychiatric Association Publishing
Date: 12-2021
Network localization of cervical dystonia based on causal brain lesions
Publisher: Oxford University Press (OUP)
Date: 28-05-2019
DOI: 10.1093/BRAIN/AWZ112
Identification of Personalized Transcranial Magnetic Stimulation Targets Based on Subgenual Cingulate Connectivity: An Independent Replication
Publisher: Elsevier BV
Date: 11-2021
Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease
Publisher: Springer Science and Business Media LLC
Date: 08-07-2021
Causal mapping of human brain function
Publisher: Springer Science and Business Media LLC
Date: 20-04-2022
The future of brain circuit-targeted therapeutics
Publisher: Springer Science and Business Media LLC
Date: 31-07-2023
Bringing Human Brain Connectomics to Clinical Practice in Psychiatry
Publisher: Elsevier BV
Date: 03-2023
Risk factors, risk stratification and risk-specific surveillance strategies after endovascular aneurysm repair: study protocol for a Delphi study by the International RIsk Stratification in EVAR (IRIS
Publisher: BMJ
Date: 04-2022
DOI: 10.1136/BMJOPEN-2021-055803
Abstract: Several risk factors for adverse events after endovascular aneurysm repair (EVAR) have been described, but there is no consensus on their comparative prognostic significance, use in risk stratification and application in determining postoperative surveillance. A scoping review of the literature was conducted to identify risk factors for adverse events after EVAR. Main adverse events were considered post-EVAR abdominal aortic aneurysm rupture and reintervention. Risk factors were grouped into four domains: (1) preoperative anatomy, (2) aortic device, (3) procedure performance and (4) postoperative surveillance. The Delphi methodology will be used to steer a group of experts in the field towards consensus organised into three tiers. In tier 1, participants will be asked to independently rate risk factors for adverse events after EVAR. In tier 2, the panel will be asked to independently rate a range of combinations of risk factors across the four domains derived from tier 1. A risk-stratification tool will then be built, which will include algorithms that map responses to signalling questions onto a proposed risk judgement for each domain. Domain-level judgements will in turn provide the basis for an overall risk judgement for the in idual patient. In tier 3, risk factor-informed surveillance strategies will be developed. Each tier will typically include three rounds and rating will be conducted using a 4-point Likert scale, with an option for free-text responses. Research Ethics Committee and Health Research Authority approval has been waived, since this is a professional staff study and no duty of care lies with the National Health Service to any of the participants. The results will be presented at regional, national and international meetings and will be submitted for publication in peer-reviewed journals. The risk stratification tool and surveillance algorithms will be made publicly available for clinical use and validation.
Heterogeneous neuroimaging findings across substance use disorders localize to a common brain network
Publisher: Springer Science and Business Media LLC
Date: 25-09-2023
‘Expedited Interhemispheric Inhibition’: A Simple Method to Collect Additional IHI Data in the Same Amount of Time
Publisher: Springer Science and Business Media LLC
Date: 03-11-2020
Brain lesions disrupting addiction map to a common human brain circuit
Publisher: Springer Science and Business Media LLC
Date: 06-2022
DOI: 10.1038/S41591-022-01834-Y
Abstract: Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. We analyzed two cohorts of patients addicted to smoking at the time of focal brain damage (cohort 1 n = 67 cohort 2 n = 62). Lesion locations were mapped to a brain atlas and the brain network functionally connected to each lesion location was computed using human connectome data ( n = 1,000). Associations with addiction remission were identified. Generalizability was assessed using an independent cohort of patients with focal brain damage and alcohol addiction risk scores ( n = 186). Specificity was assessed through comparison to 37 other neuropsychological variables. Lesions disrupting smoking addiction occurred in many different brain locations but were characterized by a specific pattern of brain connectivity. This pattern involved positive connectivity to the dorsal cingulate, lateral prefrontal cortex, and insula and negative connectivity to the medial prefrontal and temporal cortex. This circuit was reproducible across independent lesion cohorts, associated with reduced alcohol addiction risk, and specific to addiction metrics. Hubs that best matched the connectivity profile for addiction remission were the paracingulate gyrus, left frontal operculum, and medial fronto-polar cortex. We conclude that brain lesions disrupting addiction map to a specific human brain circuit and that hubs in this circuit provide testable targets for therapeutic neuromodulation.
Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression
Publisher: Elsevier BV
Date: 11-2021
Epidemiology of leprosy identified through active case detection in six districts of Nepal
Publisher: Cold Spring Harbor Laboratory
Date: 17-08-2022
DOI: 10.1101/2022.08.16.22278814
Abstract: Nepal has achieved and sustained elimination of leprosy as a public health problem since 2009, but 17 districts and 3 provinces have yet to eliminate the disease. Pediatric cases and grade-2 disabilities (G2D) indicate recent transmission and late diagnosis respectively, which necessitate active and early case detection. This operational research was performed to identify approaches best suited for early case detection, determine community-based leprosy epidemiology, and identify hidden leprosy cases early and respond with prompt treatment. Active case detection was performed by: house-to-house visits among vulnerable populations ( n= 26,469), contact examination and tracing ( n= 7,608) and screening prison populations ( n= 4,428) in Siraha, Bardiya, Rautahat, Banke, Lalitpur and Kathmandu districts of Nepal. New case detection rates were highest for contact tracing (250), followed by house-to-house visits (102) and prison screening (45) per 100,000 population screened. However, cost per case identified was cheapest for house-to-house visits (Nepalese rupee (NPR) 76,500/case), then contact tracing (NPR90,286/case) and prison screening (NPR298,300/case). House-to-house and contact tracing case paucibacillary/multibacillary (PB:MB) ratios were 59:41 and 68:32 female/male ratios 63:37 and 57:43 pediatric cases 11% in both approaches and G2D 11% and 5% respectively. Developing leprosy was similar among household and neighbor contacts (Odds ratios ( OR )=1.4, 95% confidence interval (CI), 0.24-5.85) and for contacts of MB versus PB cases ( OR= 0.7, 0.26-2.0). Attack rates were similar among household contacts of MB cases (0.32%, 0.07-0.94%) and PB cases (0.13%, 0.03-0.73) and neighbor contacts of MB cases (0.23%, 0.1-0.46) and PB cases (0.48%, 0.19-0.98). BCG vaccination with scar presence had a significant protective effect against leprosy ( OR= 0.42, 0.22-0.81). The most effective case identification approach here is contact tracing, followed by house-to-house visits in vulnerable populations and screening in prisons, though house-to-house visits were cheaper. The findings suggest hidden cases, recent transmission, and late diagnosis in the community exist and highlight the importance of early case detection.
Risk of bias and reporting completeness of randomised controlled trials in burn care: protocol for a systematic review
Publisher: BMJ
Date: 12-2019
DOI: 10.1136/BMJOPEN-2019-033472
Abstract: Burn care represents a healthcare and economic burden to patients internationally. Choice of the most clinically effective treatment strategies requires evidence which is best obtained through high-quality randomised controlled trials (RCT). The number of published RCTs of burn care is increasing. However, trial quality and reporting standards are unclear. This study will assess the risk of bias and adequacy of reporting in recent burn care RCTs using tools endorsed by the Cochrane Collaboration. A systematic literature review will be undertaken, assessing parallel group RCTs evaluating therapeutic interventions for patients with cutaneous burns. Literature searches will use Ovid Medline, Ovid Embase, Web of Science and the Cochrane Library. Separate searches for each database will include medical subject heading and free text terms including ‘burn’, ‘scald’, ‘thermal injury’ and ‘RCT’. Two reviewers will independently assess each study for inclusion. Risk of bias (RoB) will be assessed with the revised tool (RoB 2) and reporting completeness with the CONsolidated Standards of Reporting Trials (CONSORT) 2010 guidelines. We will report a narrative synthesis of all studies, including domain specific, and overall risk of bias for the primary outcome of each trial. Inter-rater agreement for RoB 2 will be reported using Fleiss’s Kappa. For adherence to the CONSORT guidelines, we will generate a completeness of reporting index for the five domains. No ethics approval is required because published documents will be used. Findings of the study will be disseminated in a peer-reviewed journal and presented at conferences. CRD42018111020.
A Human Depression Circuit Derived From Focal Brain Lesions
Publisher: Elsevier BV
Date: 11-2019
Related Organisations
Oriel College, University Of Oxford
Location: United Kingdom of Great Britain and Northern Ireland
M J William LTD
Location: United Kingdom of Great Britain and Northern Ireland
Asda Pharmacy
Location: United Kingdom of Great Britain and Northern Ireland
University Of Bristol School Of Social And Community Medicine
Location: United Kingdom of Great Britain and Northern Ireland
University Of Bristol
Location: United Kingdom of Great Britain and Northern Ireland
University Of Oxford University College Oxford
Location: United Kingdom of Great Britain and Northern Ireland
M J Williams Ltd
Location: United Kingdom of Great Britain and Northern Ireland
University Of Brighton - Moulsecoomb Campus
Location: United Kingdom of Great Britain and Northern Ireland
University Of Bath
Location: United Kingdom of Great Britain and Northern Ireland
Washington University In Saint Louis
Location: United States of America
Related Funding Activities
No related grants have been discovered for Michael Fox.