ORCID Profile
0000-0002-0951-3596
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Publisher: Oxford University Press (OUP)
Date: 28-10-2023
DOI: 10.1093/NAR/GKAD962
Publisher: MDPI AG
Date: 06-07-2021
Abstract: The attrition rate of longitudinal study participation remains a challenge. To date, the Malaysian Cohort (TMC) study follow-up rate was only 42.7%. This study objective is to identify the cause of attrition among TMC participants and the measures to curb it. A total of 19,343 TMC participants from Kuala Lumpur and Selangor that was due for follow-up were studied. The two most common attrition reasons are undergoing medical treatment at another government or private health center (7.0%) and loss of interest in participating in the TMC project (5.1%). Those who were inclined to drop out were mostly Chinese, aged 50 years and above, unemployed, and had comorbidities during the baseline recruitment. We have also contacted 2183 participants for the home recruitment follow-up, and about 10.9% agreed to join. Home recruitment slightly improved the overall follow-up rate from 42.7% to 43.5% during the three-month study period.
Publisher: Wiley
Date: 04-2023
DOI: 10.1002/JCLA.24898
Abstract: Glycated haemoglobin (HbA1c) is a standard indication for screening type 2 diabetes that also has been widely used in large‐scale epidemiological studies. However, its long‐term quality (in terms of reproducibility) stored in liquid nitrogen is still unknown. This study is aimed to evaluate the stability and reproducibility of HbA1c measurements from frozen whole blood s les kept at −196°C for more than 7 years. A total of 401 whole blood s les with a fresh HbA1c measurement were randomly selected from The Malaysian Cohort's (TMC) biobank. The HbA1c measurements of fresh and frozen (stored for 7–8 years) s les were assayed using different high‐performance liquid chromatography (HPLC) systems. The HbA1c values of the fresh s les were then calculated and corrected according to the later system. The reproducibility of HbA1c measurements between calculated‐fresh and frozen s les was assessed using a Passing‐Bablok linear regression model. The Bland–Altman plot was then used to evaluate the concordance of HbA1c values. The different HPLC systems highly correlated ( r = 0.99) and agreed (ICC = 0.96) with each other. Furthermore, the HbA1c measurements for frozen s les strongly correlate with the corrected HbA1c values of the fresh s les ( r = 0.875) with a mean difference of −0.02 (SD: −0.38 to 0.38). Although the mean difference is small, discrepancies were observed within the diabetic and non‐diabetic s les. These data demonstrate that the HbA1c measurements between fresh and frozen s les are highly correlated and reproducible.
No related grants have been discovered for Ying-Xian Goh.