ORCID Profile
0000-0002-4511-0954
Current Organisations
Royal College of Surgeons of England
,
The Welsh Centre for Burns and Plastic Surgery
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Publications
Chemical and Mechanical Alternatives to Leech Therapy: A Systematic Review and Critical Appraisal
Publisher: Georg Thieme Verlag KG
Date: 21-07-2011
Abstract: Although leech therapy is a well-established, effective method of relieving venous congestion, it is associated with complications such as wound infection and leech migration. To minimize these risks, efforts to reproduce their effects have been developed and investigated. A search string using (chemical OR mechanical OR alternative) AND (Leeches OR HIRUDO MEDICINALIS) in Boolean format was used across the major electronic databases to cover the past 10 years. Selected references were subsequently validated against critical appraisal frameworks and classified and evaluated against a framework of hierarchies of evidence. Out of 95 retrieved studies, 25 articles were selected after content appraisal. Of these, 12 articles were methodologically and statistically robust. The heterogeneity noted in the studies precluded meta-analysis of the results. The studies infer evidence at Grade B level that current device prototypes show proof of concept by providing suction and chemical anticoagulation following a surgically created wound. Although progress had been made to replicate leech action, there are still areas to address in future research. This article represents the current state of play in clinical translation of these concepts, providing efficacious devices without the drawbacks of traditional leech therapy.
The efficacy of medicinal leeches in plastic and reconstructive surgery: A systematic review of 277 reported clinical cases
Publisher: Wiley
Date: 03-2012
DOI: 10.1002/MICR.20971
Abstract: Although there are numerous case reports and small case series describing the experiences of leech therapy in various circumstances, there are relatively few large studies evaluating the effectiveness of leeching to relieve venous congestion. The therapeutic value of leeching is illustrated by these reports but the current literature lacks a cohesive summary of previous experiences. An electronic search of PubMed, the Cochrane library and the Centre for Reviews and Dissemination between 1966 and 2009 was used to retrieve human studies published in the English language evaluating outcomes following leech therapy. The "success" and "failure" of leech therapy were the primary outcome measures and secondary outcomes included complications, number of leeches used, pharmacological adjuncts and blood transfusion requirements. In total, out of 461 articles, 394 articles met the exclusion criteria. The 67 included papers reported on 277 cases of leech use with an age range of 2-81 years and a male to female ratio of almost 2:1. The overall reported "success" rate following leech therapy was 77.98% (216/277). In terms of secondary outcome measures, 49.75% of cases (N = 101) required blood transfusions, 79.05% received antibiotics (N = 166) and 54.29% received concomitant anticoagulant therapy. The overall complication rate was 21.8%. In the absence of robust randomized controlled trials on which the evidence may be based, this synthesis of current best evidence guides clinicians during the process of consenting patients and using leeches in their practice.
Related Organisations
Cardiff University
Location: United Kingdom of Great Britain and Northern Ireland
Royal College Of Surgeons Of Edinburgh
Location: United Kingdom of Great Britain and Northern Ireland
Royal College Of Surgeons Of England
Location: United Kingdom of Great Britain and Northern Ireland
Swansea University
Location: United Kingdom of Great Britain and Northern Ireland
The Welsh Centre For Burns And Plastic Surgery
Location: United Kingdom of Great Britain and Northern Ireland
Related Funding Activities
No related grants have been discovered for Ernest Azzopardi.