ORCID Profile
0000-0003-1056-4152
Current Organisation
Shandong University
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Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8CC10195G
Abstract: Synthesis of coordination polymer thin films which are tough and highly oriented is of vital importance for exploring electronic functions under mechanical stimulation.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1BM00866H
Abstract: A potent ionizable lipid for in vitro and in vivo mRNA delivery was identified through the optimization of lipid amine-head groups.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NR07854G
Abstract: High-performance hexaferrite magnets of aligned single-domain nanoplatelets are obtained by supercritical synthesis and compaction through Spark Plasma Sintering.
Publisher: American Chemical Society (ACS)
Date: 27-09-2022
DOI: 10.1021/JACS.2C06877
Abstract: Surface modification with poly(ethylene glycol) (PEGylation) is an effective strategy to improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular uptake and clearance of NPs by the immune system. However, PEGylation can also trigger the accelerated blood clearance (ABC) phenomenon, which is known to reduce the circulation time of PEGylated NPs. Herein, we report the engineering of stealth PEG NPs that can avoid the ABC phenomenon and, when modified with hyaluronic acid (HA), show specific cancer cell targeting and drug delivery. PEG NPs cross-linked with disulfide bonds are prepared by using zeolitic imidazolate framework-8 NPs as templates. The reported templating strategy enables the simultaneous removal of the template and formation of PEG NPs under mild conditions (pH 5.5 buffer). Compared to PEGylated liposomes, PEG NPs avoid the secretion of anti-PEG antibodies and the presence of anti-PEG IgM and IgG did not significantly accelerate the blood clearance of PEG NPs, indicating the inhibition of the ABC effect for the PEG NPs. Functionalization of the PEG NPs with HA affords PEG NPs that retain their stealth properties against macrophages, target CD44-expressed cancer cells and, when loaded with the anticancer drug doxorubicin, effectively inhibit tumor growth. The innovation of this study lies in the engineering of PEG NPs that can circumvent the ABC phenomenon and that can be functionalized for the improved and targeted delivery of drugs.
Publisher: Springer Science and Business Media LLC
Date: 13-05-2016
DOI: 10.1038/SREP25985
Abstract: Magnetic property is one of the important properties of nanomaterials. Direct investigation of the magnetic property on the nanoscale is however challenging. Herein we present a quantitative measurement of the magnetic properties including the magnitude and the orientation of the magnetic moment of strontium hexaferrite (SrFe 12 O 19 ) nanostructures using magnetic force microscopy (MFM) with nanoscale spatial resolution. The measured magnetic moments of the as-synthesized in idual SrFe 12 O 19 nanoplatelets are on the order of ~10 −16 emu . The MFM measurements further confirm that the magnetic moment of SrFe 12 O 19 nanoplatelets increases with increasing thickness of the nanoplatelet. In addition, the magnetization directions of nanoplatelets can be identified by the contrast of MFM frequency shift. Moreover, MFM frequency imaging clearly reveals the tiny magnetic structures of a compacted SrFe 12 O 19 pellet. This work demonstrates the mesoscopic investigation of the intrinsic magnetic properties of materials has a potential in development of new magnetic nanomaterials in electrical and medical applications.
No related grants have been discovered for Qiang Li.