ORCID Profile
0009-0001-8502-003X
Current Organisations
The Kulinda Consortium
,
The Purnima Foundation
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Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Date: 15-03-2002
DOI: 10.1167/2.7.610
Publisher: Springer Science and Business Media LLC
Date: 10-2010
DOI: 10.1007/S10803-010-1109-5
Abstract: The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevelopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue).
Publisher: American Psychological Association (APA)
Date: 2003
Abstract: Identifying a criminal captured on conventional security video typically requires matching poor-quality video footage against a high-quality photograph. The authors examined the consequence of such a large discrepancy in image quality. Recognition and matching performance of this incongruent-quality condition was compared with that of a congruent one, in which a high-quality photograph was reduced to a low-quality video. Recognition memory was little affected by this manipulation, whereas matching performance of the incongruent condition enjoyed occasional advantage. The results show that person identification can tolerate a large discrepancy between image qualities of matching stimuli when one of the images is of poor quality.
Publisher: Oxford University Press (OUP)
Date: 07-11-2004
DOI: 10.1093/BRAIN/AWH069
Publisher: Elsevier BV
Date: 04-2009
DOI: 10.1016/J.BRAINRES.2009.01.059
Abstract: Fragile X syndrome (FXS) is one of the most prevalent forms of heritable mental retardation and developmental delay in males. The syndrome is caused by the silencing of a single gene (fragile X mental retardation-1 FMR1) and the lack of expression of its protein product (fragile X mental retardation-1 protein FMRP). Recent work has linked the high expression levels of FMRP in the magnocellular layers of lateral geniculate nucleus (M-LGN) of the visual system to a specific reduction of perceptual function known to be mediated by that neural structure. This finding has given rise to the intriguing notion that FMRP expression level may be used as an index of susceptibility of specific brain regions to the observed perceptual and cognitive deficits in FXS. We undertook a comprehensive expression profiling study of FMRP in the monkey to obtain further insight into the link between FMPR expression and the behavioural impact of its loss in FXS. We report here the first 3D whole-brain map of FMRP expression in the Old-World monkey and show that certain brain structures display high FMRP levels, such as the cerebellum, striatum, and temporal lobe structures. This finding provides support for the notion that FMRP expression loss is linked to behavioural and cognitive impairment associated with these structures. We argue that whole-brain FMRP expression mapping may be used to formulate and test new hypotheses about other forms of impairments in FXS that were not specifically examined in this study.
Publisher: Elsevier BV
Date: 12-1999
DOI: 10.1016/S0042-6989(99)00109-1
Abstract: Face recognition in photographic positive and negative was examined in a same/different matching task in five lighting direction conditions using untextured 3-D laser-scanned faces. The lighting directions were +60, +30, 0, -30 and -60 degrees, where negative values represent bottom lighting and positive values represent top lighting. Recognition performance was better for faces in positive than in negative when lighting directions were at +60 degrees. In one experiment, the same effect was also found at +30 degrees. However, faces in negative were recognized better than positive when the direction was -60 degrees. There was no difference in recognition performance when the lighting direction was 0 and -30 degrees. These results confirm that the effect of lighting direction can be a determinant of the photographic negative effect. Positive faces, which normally appear to be top-lit, may be difficult to recognize in negative partly because of the accompanying change in apparent lighting direction to bottom-lit.
Publisher: Springer Science and Business Media LLC
Date: 25-09-2010
DOI: 10.1007/S10803-010-1110-Z
Abstract: We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism's pathogenesis. The usefulness of such a translational research approach is discussed.
Location: United States of America
No related grants have been discovered for Avijit Chaudhuri, PhD.