ORCID Profile
0000-0003-2739-5578
Current Organisations
University Medical Center Hamburg-Eppendorf
,
San Diego State University
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Publisher: Elsevier BV
Date: 11-2016
Publisher: Cold Spring Harbor Laboratory
Date: 24-08-2020
DOI: 10.1101/2020.08.23.263392
Abstract: Morphologic examination of tissue biopsies is essential for histopathological diagnosis. However, accurate and scalable cellular quantification in human s les remains challenging. Here, we present a deep learning-based approach for antigen-specific cellular morphometrics in human kidney biopsies, which combines indirect immunofluorescence imaging with U-Net-based architectures for image-to-image translation and dual segmentation tasks, achieving human-level accuracy. In the kidney, podocyte loss represents a hallmark of glomerular injury and can be estimated in diagnostic biopsies. Thus, we profiled over 27,000 podocytes from 110 human s les, including patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN), an immune-mediated disease with aggressive glomerular damage and irreversible loss of kidney function. Previously unknown morphometric signatures of podocyte depletion were identified in patients with ANCA-GN, which allowed patient classification and showed potential for risk stratification in combination with routine clinical tools. Together, our approach enables robust and scalable molecular morphometric analysis of human tissues, yielding deeper biological insights into the human kidney pathophysiology. Deep learning enables robust and scalable molecular morphometric analysis of human tissues, yielding deeper biological insights into the human kidney pathophysiology.
Publisher: Elsevier BV
Date: 06-2019
Publisher: American Association for the Advancement of Science (AAAS)
Date: 14-08-2020
DOI: 10.1126/SCIIMMUNOL.ABA4163
Abstract: CD4 + T RM 17 cells become activated by inflammatory cytokines to produce IL-17A and thereby promote autoimmunity.
Publisher: American Society for Clinical Investigation
Date: 08-04-2021
Publisher: American Association for the Advancement of Science (AAAS)
Date: 12-02-2021
DOI: 10.1126/SCIIMMUNOL.ABF6692
Abstract: Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.
Publisher: Elsevier BV
Date: 08-2021
No related grants have been discovered for Christian F. Krebs.