ORCID Profile
0000-0002-1935-8710
Current Organisation
Monash University
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Publisher: Wiley
Date: 21-04-2021
Abstract: Using the compound [Ru II (FT)(bipy)(NO)](PF 6 ) 3 (FT is the electron‐rich 4’‐(2‐fluorenyl)‐2,2’:6’,2’’‐terpyridine ligand and bipy is 2–2’bipyridine) as a reference, two new compounds are presented in which carbon‐carbon double and triple bonds are inserted between the fluorenyl substituent and the terpyridine to provide an extended conjugation path. The electronic properties of the three complexes are compared experimentally by UV‐visible spectroscopy and computationally by means of the density functional theory. All of them exhibit a capability for NO release under irradiation on their low‐energy transition located in the 400–500 nm range, with a quantum yield around 0.01. Their two‐photon absorption (TPA) cross sections are investigated by the Z‐scan technique at λ =800 nm. While the reference compound exhibits a cross‐section equal to 108 GM, the introduction of double and triple bonds leads to increased cross‐sections equal to 131 GM and 150 GM, respectively. These values are discussed in reference to the two‐level model in use for “push‐pull” dipolar TPA chromophores.
Publisher: American Chemical Society (ACS)
Date: 22-07-2020
Publisher: American Chemical Society (ACS)
Date: 06-06-2023
Publisher: Bentham Science Publishers Ltd.
Date: 24-12-2020
DOI: 10.2174/1570193X17666200220130735
Abstract: The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as & #947 - butenolides or appropriately as & #916 sup & #945 ,& #946 /sup -butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, & #916 sup & #945 ,& #946 /sup -butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the & #916 sup & #945 ,& #946 /sup -butenolide ring formation, along with selected ex les of compounds with relevant biological activities of these promising pharmaceutical entities is presented.
Publisher: Wiley
Date: 05-09-2022
Abstract: One monometallic and three bimetallic ruthenium nitrosyl (RuNO) complexes are presented and fully characterized in reference to a parent monometallic complex of formula [FTRu(bpy)(NO)] 3+ , where FT is a fluorenyl‐substituted terpyridine ligand, and bpy the 2,2’‐bipyridine. These new complexes are built with the new ligands FFT, TFT, TFFT, and TF‐CC‐TF (where an alkyne C≡C group is inserted between two fluorenes). The crystal structures of the bis‐RuNO 2 and bis‐RuNO complexes built from the TFT ligand are presented. The evolution of the spectroscopic features (intensities and energies) along the series, at one‐photon absorption (OPA) correlates well with the TD‐DFT computations. A spectacular effect is observed at two‐photon absorption (TPA) with a large enhancement of the molecular cross‐section ( σ TPA ), in the bimetallic species. In the best case, σ TPA is equal to 1523±98 GM at 700 nm, in the therapeutic window of transparency of biological tissues. All compounds are capable of releasing NO⋅ under irradiation, which leads to promising applications in TPA‐based drug delivery.
No related grants have been discovered for Andrés Felipe León Rojas.