ORCID Profile
0000-0001-5330-7186
Current Organisations
University of Potsdam
,
Universität Potsdam
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Publisher: American Chemical Society (ACS)
Date: 13-10-2015
Publisher: American Chemical Society (ACS)
Date: 11-10-2021
Publisher: American Chemical Society (ACS)
Date: 09-11-2017
Abstract: Antimicrobial polymers appear as a promising alternative to tackle the current development of bacterial resistance against conventional antibiotics as they rely on bacterial membrane disruption. This study investigates the effect of segmentation of hydrophobic and cationic functionalities on antimicrobial polymers over their selectivity between bacteria and mammalian cells. Using RAFT technology, statistical, diblock, and highly segmented multiblock copolymers were synthesized in a controlled manner. Polymers were analyzed by HPLC, and the segmentation was found to have a significant influence on their overall hydrophobicity. In addition, the amount of incorporated cationic comonomer was varied to yield a small library of bioactive macromolecules. The antimicrobial properties of these compounds were probed against pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis), and their biocompatibility was tested using hemolysis and erythrocyte aggregation assays, as well as mammalian cell viability assays. In all cases, diblock and multiblock copolymers were found to outperform statistical copolymers, and for polymers with a low content of cationic comonomer, the multiblock showed a tremendously increased selectivity for P. aeruginosa and S. epidermidis compared to its statistical and diblock analogue. This work highlights the remarkable effect of segmentation on both the physical properties of the materials as well as their interaction with biological systems. Due to the outstanding selectivity of multiblock copolymers toward certain bacteria strains, the presented materials are a promising platform for the treatment of infections and a valuable tool to combat antimicrobial resistance.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TB00193A
Abstract: The antifouling properties against the simultaneous attack of five different bacteria and the stability of surface tethered poly(2-ethyl-2-oxazoline)s were investigated.
Publisher: Wiley
Date: 07-08-2018
Abstract: Current approaches to generate core-shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming these challenges. In this work, well-defined PEGylated nanoparticles are synthesized using reversible addition fragmentation chain transfer emulsion polymerization to control particle size and surface composition and were further characterized with light scattering, electron microscopy, and size exclusion chromatography. Importantly, the nanoparticles are found to be tolerated both in vitro and in vivo, without the need for any purification after particle synthesis. Pharmacokinetic and biodistribution studies in mice, following intraperitoneal injection of the nanoparticles, reveal a long (>76 h) circulation time and accumulation in the liver.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4TB01660B
Abstract: We discuss covalently cross-linked poly(2-oxazoline)s including gels, nanogels and capsules on the basis of their synthetic origin in a biomedical context.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9PY01342C
Abstract: Supramolecular polymers are non-covalent assemblies of unimeric building blocks connected by secondary interactions and hold great promises due to their dynamic nature.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3SM00114H
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6PY00940A
Abstract: PEI was chemically-modified with carbohydrates and carbohydrate-mimetics to improve biocompatibility.
Publisher: Wiley
Date: 25-10-2023
DOI: 10.1002/POL.20230591
Publisher: American Chemical Society (ACS)
Date: 29-01-2019
DOI: 10.1021/ACS.BIOMAC.8B01709
Abstract: A synthetic cell mimic in the form of giant glycosylated polymersomes (GGPs) comprised of a novel hiphilic diblock copolymer is reported. A synthetic approach involving a poly(dimethylsiloxane) (PDMS) macro-chain transfer agent (macroCTA) and postpolymerization modification was used to marry the hydrophobic and highly flexible properties of PDMS with the biological activity of glycopolymers. 2-Bromoethyl acrylate (BEA) was first polymerized using a PDMS macroCTA ( M
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CC07241D
Abstract: The combination of the reversible addition fragmentation chain transfer (RAFT) polymerization R-group grafting from approach and RAFT one-pot acrylamide multiblock methodology is used to synthesise complex bottle-brush architectures.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7PY00828G
Abstract: pH/sugar responsive behaviour of tadpole-like single chain nanoparticles based on a switchable hydrophilic/hydrophobic boronic acid cross-linker is described.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TB00490A
Abstract: The influence of polymer architecture of cationic polymers on gene transfection is investigated. Bottle brush copolymers are shown to outperform linear counterparts.
Publisher: Wiley
Date: 07-11-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SC00756C
Abstract: Cyclic peptide nanotubes were coupled to poly(oxazoline)s using a cleavable connection. Upon stimuli responsive detachment of the polymer an on-demand membrane activity could be achieved.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7PY00787F
Abstract: Functional multisite copolymers with a controlled number and position of side chains were synthesized by a one-pot RAFT polymerization process and post-functionalization.
Publisher: American Chemical Society (ACS)
Date: 14-09-2017
Publisher: American Chemical Society (ACS)
Date: 19-03-2014
DOI: 10.1021/BM4017572
Abstract: A series of copolymers containing both amine groups of linear poly(ethylene imine) (LPEI) and double bonds of poly(2-(3-butenyl)-2-oxazoline) (PButEnOx) was prepared. To this end, a poly(2-ethyl-2-oxazoline) (PEtOx) precursor was hydrolyzed to the respective LPEI and functionalized in an amidation reaction with butenyl groups resulting in the double bond containing poly(2-(3-butenyl-2-oxazoline)-co-ethylene imine) (P(ButEnOx-co-EI)). Hydrogels were obtained by cross-linking with dithiols under UV-irradiation resulting in networks with different properties in dependence of the content of double bonds. The developed method allows the exact control of the amount of ethylene imine units within the copolymer and, thus, within the resulting hydrogels. The gel structures were characterized by solid state NMR and infrared spectroscopy. In addition the water uptake behavior from the liquid and the gas phase was investigated. It was shown by an ethidium bromide assay (EBA) that the copolymers and the respective hydrogels were able to bind and release DNA. Furthermore, the influence of the ethylene imine content on this interaction was investigated.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7PY00630F
Abstract: A flexible, robust and time-efficient scale-up of multiblock copolymers with low dispersity and high livingness.
Publisher: Wiley
Date: 18-11-2014
DOI: 10.1002/POLA.27457
Publisher: American Chemical Society (ACS)
Date: 05-05-2014
DOI: 10.1021/BM500236Y
Abstract: We describe the synthesis of matrix supported hydrogel structures based on amine containing poly(2-oxazoline)s and their use to bind and release genetic material for potential applications in diagnostics or pathogen detection. Amine containing poly(2-oxazoline)s were synthesized by copolymerization of 2-ethyl-2-oxazoline with a monomer bearing a tert-butyl oxycarbonyl (Boc) protected amine group in the 2-position and subsequent deprotection. The statistical copolymers were used to generate hydrogels and matrix supported hydrogels by cross-linking of a certain fraction of the amine groups with epichlorhydrin. Supported structures were prepared by soaking porous polyethylene (PE) or polypropylene (PP) filter materials in a copolymer/epichlorhydrin solution, which was cross-linked upon heating. Scanning electron microscopy (SEM) of the composites revealed a bead like structure of the gel phase, which could be attributed to a lower critical solution temperature (LCST) behavior of the initial polymer prior to gelation. The dependency of the LCST behavior on the content of amine groups was investigated. Swelling values and the ratio of hydrogel per composite was determined using water sorption analysis. Subsequently, the ability of the systems to absorb and release labeled DNA was tested. Uptake and stimulated release, triggered by changes in pH, temperature, and heparin concentration, were investigated using fluorescence microscopy. Polymerase chain reaction (PCR) proved the successful recovery of the DNA, demonstrating the potential of the presented system for a broad range of molecular biological applications.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4TB02069C
Abstract: The synthesis of poly(2-oxazoline)-based block copolymers consisting of a cationic and a hydrophilic segment is described.
Location: United Kingdom of Great Britain and Northern Ireland
Location: Germany
No related grants have been discovered for Matthias Hartlieb.