ORCID Profile
0000-0002-2031-4643
Current Organisation
National Institute of Animal Biotechnology
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Publisher: Public Library of Science (PLoS)
Date: 07-02-2011
Publisher: Springer Science and Business Media LLC
Date: 26-04-2021
Publisher: Elsevier BV
Date: 02-2022
Publisher: Hindawi Limited
Date: 2017
DOI: 10.1155/2017/5498054
Abstract: Inflammation is the major causative factor of different diseases such as cardiovascular disease, diabetes, obesity, osteoporosis, rheumatoid arthritis, inflammatory bowel disease, and cancer. Anti-inflammatory drugs are often the first step of treatment in many of these diseases. The present study is aimed at evaluating the anti-inflammatory properties of isoorientin, a selective cyclooxygenase-2 (COX-2) inhibitor isolated from the tubers of Pueraria tuberosa , in vitro on mouse macrophage cell line (RAW 264.7) and in vivo on mouse paw edema and air pouch models of inflammation. Isoorientin reduced inflammation in RAW 264.7 cell line in vitro and carrageenan induced inflammatory animal model systems in vivo. Cellular infiltration into pouch tissue was reduced in isoorientin treated mice compared to carrageenan treated mice. Isoorientin treated RAW 264.7 cells and animals showed reduced expression of inflammatory proteins like COX-2, tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), 5-lipoxygenase (5-LOX), and interleukin 1- β (IL-1- β ) both in vitro and in vivo. The antioxidant enzyme levels of catalase and GST were markedly increased in isoorientin treated mice compared to carrageenan treated mice. These results suggest that isoorientin, a selective inhibitor of COX-2, not only exerts anti-inflammatory effects in LPS induced RAW cells and carrageenan induced inflammatory model systems but also exhibits potent antioxidant properties.
No related grants have been discovered for Anand Srivastava.