ORCID Profile
0000-0003-0547-3336
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Publisher: Wiley
Date: 20-06-2016
DOI: 10.1111/PCMR.12485
Abstract: Vitiligo is a multifactorial acquired depigmenting disorder. Recent insights into the molecular mechanisms driving the gradual destruction of melanocytes in vitiligo will likely lead to the discovery of novel therapies, which need to be evaluated in animal models that closely recapitulate the pathogenesis of human vitiligo. In humans, vitiligo is characterized by a spontaneous loss of functional melanocytes from the epidermis, but most animal models of vitiligo are either inducible or genetically programmed. Here, we report that acquired depigmentation in water buffalo recapitulates molecular, histological, immunohistochemical, and ultrastructural changes observed in human vitiligo and hence could be used as a model to study vitiligo pathogenesis and facilitate the discovery and evaluation of therapeutic interventions for vitiligo.
Publisher: Elsevier BV
Date: 05-2019
Location: Netherlands
Location: India
Location: India
Location: United Kingdom of Great Britain and Northern Ireland
Location: No location found
No related grants have been discovered for Vijay Pal Singh.