Artemis Stamboulis

Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system

Publisher: Elsevier BV

Date: 11-2019

DOI: 10.1016/J.MSEC.2019.109757

Abstract: Post-operative infection often occurs following orthopedic and dental implant placement requiring systemically administered antibiotics. However, this does not provide long-term protection. Over the last few decades, alternative methods involving slow drug delivery systems based on biodegradable poly-lactic acid and antibiotic loaded hydroxyapatite microspheres were developed to prevent post-operative infection. In this study, thermally anodised and untreated Ti6Al4V discs were coated with Poly-Lactic Acid (PLA) containing Gentamicin (Gm) antibiotic-loaded coralline Hydroxyapatite (HAp) are investigated. Following chemical characterization, mechanical properties of the coated s les were measured using nanoindentation and scratch tests to determine the elastic modulus, hardness and bonding adhesion between film and substrate. It was found that PLA biocomposite multilayered films were around 400nm thick and the influence and effect of the substrate were clearly observed during the nanoindentation studies with heavier loads. Scratch tests of PLA coated s les conducted at ~160nm depth showed the minimal difference in the measured friction between Gm and non Gm containing films. It is also observed that the hardness values of PLA film coated anodised s les ranged from 0.45 to 1.9GPa (dependent on the applied loads) against untreated coated s les which ranged from 0.28 to 0.8GPa.

A Versatile Elastin‐Like Carrier for Bioactive Antimicrobial Peptide Production and Delivery

Publisher: Wiley

Date: 24-09-2023

DOI: 10.1002/MABI.202300236

Biocompatibility of a new biodegradable polymer-hydroxyapatite composite for biomedical applications

Publisher: Elsevier BV

Date: 04-2017

DOI: 10.1016/J.JDDST.2017.01.008

Influence of calcination on the sol–gel synthesis of lanthanum oxide nanoparticles

Publisher: Springer Science and Business Media LLC

Date: 14-11-2018

DOI: 10.1007/S00339-018-2246-5

Methodological challenges in researching threshold concepts: a comparative analysis of three projects

Publisher: Springer Science and Business Media LLC

Date: 28-03-2013

DOI: 10.1007/S10734-013-9623-Y

Polyethylene glycol assisted facile sol-gel synthesis of lanthanum oxide nanoparticles: Structural characterizations and photoluminescence studies

Publisher: Elsevier BV

Date: 2019

DOI: 10.1016/J.CERAMINT.2018.09.183

University Of Birmingham

Location: United Kingdom of Great Britain and Northern Ireland

View Organisation

Imperial College London

Location: United Kingdom of Great Britain and Northern Ireland

View Organisation

National And Kapodistrian University Of Athens - Faculty Of Medicine

Location: Greece

View Organisation

National Technical University Of Athens

Location: Greece

View Organisation

University Of Manchester

Location: United Kingdom of Great Britain and Northern Ireland

View Organisation