ORCID Profile
0000-0002-8829-9160
Current Organisations
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
,
Rensselaer Polytechnic Institute
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Publisher: CRC Press
Date: 31-10-2017
Publisher: Elsevier BV
Date: 09-2018
Publisher: Elsevier BV
Date: 11-2018
Publisher: The Optical Society
Date: 27-08-2014
DOI: 10.1364/AO.53.005672
Publisher: Springer Science and Business Media LLC
Date: 18-10-2016
DOI: 10.1007/S00134-016-4571-5
Abstract: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality. The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience s le of 459 ICUs from 50 countries across five continents. A pre-specified secondary aim was to examine the factors associated with outcome. Analyses were restricted to patients (93.1 %) fulfilling ARDS criteria on day 1-2 who received invasive mechanical ventilation. 2377 patients were included in the analysis. Potentially modifiable factors associated with increased hospital mortality in multivariable analyses include lower PEEP, higher peak inspiratory, plateau, and driving pressures, and increased respiratory rate. The impact of tidal volume on outcome was unclear. Having fewer ICU beds was also associated with higher hospital mortality. Non-modifiable factors associated with worsened outcome from ARDS included older age, active neoplasm, hematologic neoplasm, and chronic liver failure. Severity of illness indices including lower pH, lower PaO Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS. ClinicalTrials.gov NCT02010073.
Publisher: Elsevier BV
Date: 10-2022
Publisher: The Optical Society
Date: 04-03-2014
DOI: 10.1364/OE.22.005572
Location: Italy
Location: United States of America
No related grants have been discovered for Fabiana Madotto.