ORCID Profile
0000-0002-9236-0227
Current Organisation
University of Melbourne
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Publisher: Informa UK Limited
Date: 16-05-2022
Publisher: Practical Action Publishing
Date: 2009
Publisher: Oxford University Press (OUP)
Date: 27-08-2013
DOI: 10.1189/JLB.0513294
Abstract: Dendritic cells (DCs) that differentiate in vitro from the bone marrow (BM) of mice with prostaglandin E2 (PGE2)-associated inflammation of the skin, airways, or peritoneal cavity poorly initiate immune responses. To remove in vitro differentiation and allow BM-derived DCs to seed the periphery under steady-state conditions, as well as study the molecule proposed responsible, chimeric mice were engrafted for & wk with BM cells from mice exposed to PGE2. Serial PGE2-chimeric mice were established with BM cells from the primary chimeric mice. Immune responses in the airways and skin of the PGE2-chimeric mice and serial PGE2-chimeric mice were significantly attenuated. After inflammatory challenges by intranasal LPS, topical fluorescein isothiocyanate, and intraperitoneal alum, DCs, macrophages, and neutrophils trafficked poorly in PGE2-chimeric mice and serial PGE2-chimeric mice. Injection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice. DCs from BM of 16-wk-engrafted PGE2-chimeric and serial PGE2-chimeric mice resembled cells differentiated from BM exposed to PGE2 for only 3 d, demonstrating the long-lasting effect of PGE2 on DC progenitors. PGE2 attenuates systemic immune responses by modulating myeloid cell progenitors in the BM such that BM-derived, terminally differentiated myeloid cells have poor trafficking ability to sites of need.
Publisher: Springer Science and Business Media LLC
Date: 02-04-2015
DOI: 10.1007/S00267-015-0471-7
Abstract: In an effort to increase the livability of its cities, public agencies in Australia are investing in green infrastructure to improve public health, reduce heat island effects and transition toward water sensitive urban design. In this paper, we present a simple and replicable approach to building a business case for green infrastructure. This approach requires much less time and resources compared to other methods for estimating the social and economic returns to society from such investments. It is a pragmatic, reasonably comprehensive approach that includes socio-demographic profile of potential users and catchment analysis to assess the economic value of community benefits of the investment. The approach has been applied to a case study area in the City of Brimbank, a western suburb of Greater Melbourne. We find that subject to a set of assumptions, a reasonable business case can be made. We estimate potential public benefits of avoided health costs of about AU$75,049 per annum and potential private benefits of AU$3.9 million. The project area is one of the most poorly serviced areas in the municipality in terms of quality open spaces and the potential beneficiaries are from relatively low income households with less than average health status and education levels. The values of cultural (recreational benefits, avoided health costs, and increased property values) and regulating (reduction in heat island effect and carbon sequestration) ecosystem services were quantified that can potentially offset annual maintenance costs.
Publisher: Elsevier BV
Date: 05-2018
Publisher: Informa UK Limited
Date: 07-2011
Publisher: IWA Publishing
Date: 20-06-2015
DOI: 10.2166/WP.2015.191
Abstract: Wastewater recycling has emerged as a prominent option among the various alternative sources of water in both developing and developed countries. However, the questions that need to be answered in this context are: how do communities determine which option is best for them, and what are the factors that make one water alternative more appealing than another? The aim in this paper is to understand the factors that affect wastewater management across communities that are at varying stages of economic development. From an in-depth literature review of 329 studies, the factors that determine wastewater management have been grouped together into four categories: physical, economic, institutional and environmental factors. Finally, drawing on the Environmental Kuznets Curve, a framework has been developed that combines these factors that constrain or facilitate wastewater treatment and recycling over a broad spectrum of economic settings and stages of development. The factors, their components and the methods through which relevant empirical evidence can be collected to assess them, are presented and discussed in detail. In doing this, the aim is to highlight the changing nature of the four factors which will influence long-term investments in wastewater infrastructure.
No related grants have been discovered for Gayathri Devi Mekala.