ORCID Profile
0000-0002-5996-6518
Current Organisations
National Institute of Immunology
,
James Cook University
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Publisher: Springer Science and Business Media LLC
Date: 18-09-2018
Publisher: Public Library of Science (PLoS)
Date: 22-02-2019
Publisher: American Association for the Advancement of Science (AAAS)
Date: 09-06-2023
Abstract: Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Publisher: Emerald
Date: 25-11-2019
Abstract: The purpose of this paper is to discuss the practical use of theoretical s ling as a method for selecting data that provide a richer and deeper understanding of the phenomenon being investigated. Theoretical s ling is a well-known method in grounded theory studies to seek additional data based on concepts developed from initial data analysis. This method involves following where the data have led to expand and refine the evolving theory during the analytical process. However, there is a dearth of information detailing the practical steps needed to undertake theoretical s ling. The authors used the theoretical s ling method in their study in four ways: asking additional interview questions and/or widening the scope of existing interview questions recruiting participants with additional ersity of attributes within the same group and adding a new group of participants and expanding research settings. Theoretical s ling is a valuable and practical method for the purpose of addressing gaps in the data in qualitative research. When using theoretical s ling, it is essential to consider potential strategies for countering challenges that may arise. Practical recommendations are offered on the use of theoretical s ling during data analysis, for the purpose of achieving theoretical integration.
Publisher: ACM
Date: 12-05-2023
Publisher: Elsevier BV
Date: 08-2022
No related grants have been discovered for Kristin Wicking.