ORCID Profile
0000-0001-5329-1292
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Publisher: Wiley
Date: 21-07-2011
Publisher: Wiley
Date: 20-08-2009
Publisher: Wiley
Date: 19-10-2010
Publisher: Wiley
Date: 29-10-2012
Publisher: Springer Science and Business Media LLC
Date: 1991
DOI: 10.1007/BF01041177
Publisher: Wiley
Date: 07-2005
Publisher: Elsevier BV
Date: 11-1986
DOI: 10.1016/0303-7207(86)90165-6
Abstract: Administration of ethane dimethane sulphonate (EDS) (75 mg/kg) to unilaterally cryptorchid rats, results in a rapid decline in serum testosterone levels and a marked reduction in hCG binding to homogenates of scrotal and cryptorchid testes, consistent with the destruction of Leydig cells within the testes as shown by morphological and morphometric analysis. Between 3 and 7 days after EDS, serum LH and FSH levels rise, LH to levels found in castrate rats. hCG binding begins to recover in scrotal testes, reaching 32% of control values 28 days after EDS. However, the recovery of hCG binding to cryptorchid testes is more rapid, reaching 51% of control levels by 21 days which coincides with the re-establishment of serum testosterone to normal levels. Since a different rate of recovery is observed for hCG binding to scrotal and cryptorchid testes, and both testes are exposed to the same circulating levels of LH and FSH, the likely stimulus for recovery of hCG binding and regeneration of Leydig cells is intratesticular in origin. This supports the concept that local factors, released following damage to the seminiferous epithelium by cryptorchidism, play a role in the differentiation and growth of Leydig cells within the testis.
Publisher: Wiley
Date: 25-09-2009
Publisher: Wiley
Date: 2014
DOI: 10.1111/AVJ.12152
Publisher: Wiley
Date: 21-06-2010
Publisher: Wiley
Date: 19-05-2011
Publisher: Wiley
Date: 22-08-2011
Publisher: Wiley
Date: 2011
DOI: 10.1111/J.1751-0813.2011.00678.X
Abstract: The life of veterinarian Ernest Arthur Kendall · Sequential opportunistic infections in German Shepherd dogs · Small intestinal ganglioneuromatosis in a dog · Options for preventing flystrike in Merino lambs · Wound healing after mulesing and other options · Vaccination and ovine Johne's disease · Risk factors for subclinical mastitis on dairy farms · Parasites in tawny frogmouths · Peritoneopericardial diaphragmatic hernia in an alpaca · Gammaherpesvirus infection in a kangaroo
Publisher: Wiley
Date: 2013
DOI: 10.1111/AVJ.12026
Publisher: Wiley
Date: 17-04-2012
Publisher: Wiley
Date: 28-08-2012
Publisher: Wiley
Date: 26-05-2009
Publisher: Wiley
Date: 18-03-2010
Publisher: Wiley
Date: 23-11-2009
Publisher: Wiley
Date: 26-10-2015
DOI: 10.1111/AVJ.12379
Abstract: Avian influenza viruses (AIVs) are found worldwide in numerous bird species, causing significant disease in gallinaceous poultry and occasionally other species. Surveillance of wild bird reservoirs provides an opportunity to add to the understanding of the epidemiology of AIVs. This study examined key findings from the National Avian Influenza Wild Bird Surveillance Program over a 5-year period (July 2007-June 2012), the main source of information on AIVs circulating in Australia. The overall proportion of birds that tested positive for influenza A via PCR was 1.9 ± 0.1%, with evidence of widespread exposure of Australian wild birds to most low pathogenic avian influenza (LPAI) subtypes (H1-13, H16). LPAI H5 subtypes were found to be dominant and widespread during this 5-year period. Given Australia's isolation, both geographically and ecologically, it is important for Australia not to assume that the epidemiology of AIV from other geographic regions applies here. Despite all previous highly pathogenic avian influenza outbreaks in Australian poultry being attributed to H7 subtypes, widespread detection of H5 subtypes in wild birds may represent an ongoing risk to the Australian poultry industry.
Publisher: Cold Spring Harbor Laboratory
Date: 17-07-2021
DOI: 10.1101/2021.07.16.452724
Abstract: A novel Hendra virus (HeV) variant, not detected by routine testing, was identified and isolated from a Queensland horse that suffered acute, fatal disease consistent with HeV infection. Whole genome sequencing and phylogenetic analysis demonstrated the variant to have ~83% nucleotide identity to the prototype HeV strain. An updated RT-qPCR assay was designed for routine HeV surveillance. In silico and in vitro comparison of the receptor-binding protein with prototypic HeV showed that the human monoclonal antibody m102.4 used for post-exposure prophylaxis, as well as the current equine vaccine, should be effective against this variant. Genetic similarity of this virus to sequences detected from grey-headed flying-foxes suggests the variant circulates at-least in this species. Studies determining infection kinetics, pathogenicity, reservoir-species associations, viral–host co-evolution and spillover dynamics for this virus are urgently needed. Surveillance and biosecurity practices should be updated to appreciate HeV spillover risk across all regions frequented by flying foxes.
Publisher: Wiley
Date: 24-05-2010
Publisher: Wiley
Date: 29-06-2011
Publisher: Wiley
Date: 2012
DOI: 10.1111/J.1751-0813.2011.00889.X
Abstract: Options for eradication of footrot in sheep · Johne's disease in Australian beef cattle herds · Digital extensor tendon transections in racehorses · Abalone viral ganglioneuritis · Haemochromatosis in a Brazilian tapir · Disseminated Scedosporium prolificans infection in a German Shepherd dog · Osteosarcoma and orthopaedic implants · Torsion of liver lobes and gallbladder · Intimate partner violence and companion animal welfare
Publisher: Wiley
Date: 21-04-2009
Publisher: Wiley
Date: 21-03-2011
Publisher: Wiley
Date: 10-1993
DOI: 10.1038/ICB.1993.55
Abstract: A series of experiments using an ovalbumin conjugated gonadotrophin releasing hormone was used to stimulate antibody production, suppress testosterone secretion and depress testicular function in yearling and 2 year old colts and fillies. In the preliminary experiment, an injectable oil-based formulation was administered to yearling colts. Testicular development and testosterone secretion were retarded for a period of approximately 28-32 weeks while antibody titres were greater than 1:1000. An implant and water-soluble vaccine (200 and 400 mg) is presently being tested in 2 year old colts. Testicular dimensions and testosterone concentrations decreased following vaccination. Preliminary results indicate that the effects of the implant are reversible and last for approximately 30 weeks. The water-soluble vaccine produced effective antibodies for 10-19 weeks. Plasma testosterone of all colts was reduced to gelding levels (0.2 ng/mL) while antibody titres were greater than 1:1000. Semen evaluation, morphometric analysis and daily sperm production data indicate that the testes recovered normal function. These experiments are continuing and more definitive data on the vaccine and its reversibility will be available at their conclusion. Ovarian activity of the treated fillies (200 and 400 mg) ceased soon after vaccination. Their progesterone concentrations have remained below 1 ng/mL for 20 weeks. The untreated control fillies have continued to cycle normally as determined by ovarian ultrasonography and progesterone concentrations.
Publisher: Wiley
Date: 22-10-2009
Publisher: Wiley
Date: 28-09-2012
DOI: 10.1111/AVJ.12363
Abstract: To investigate the effect of activated protein C (APC) on second intention healing of distal limb wounds in horses. In this experimental study of eight Standardbred geldings, six full-thickness skin wounds (2 × 1.5 cm) were created on one metacarpus (biopsy limb) and five similar wounds were created on the contralateral metacarpus (photographed limb). Three wounds on the biopsy limb were treated topically with 190 µg APC on days 1, 3, 6 and 9, while the remaining three wounds were untreated (control). One treated and one control wound were biopsied on days 4, 7 and 11 for histopathology. Wounds on the photographed limb were treated with either 66% Manuka honey gel, a commercial antibiotic ointment (bacitracin-neomycin-polymixin B ointment BNP) or petrolatum daily throughout healing, treated on days 1,3,6 and 9 with 190 µg APC or left untreated. These wounds were digitally photographed and the wound area measured on day 1, then weekly until day 49. Overall time to healing was recorded. There was no effect of APC on wound size, the rate of healing or the overall time to heal. However, compared with control wounds, histological scoring demonstrated enhanced epithelialisation (day 4) and angiogenesis (day 11). Wound healing variables for wounds treated with APC, Manuka honey gel and control wounds were not different and the variables for wounds treated with BNP and petrolatum demonstrated delayed healing. The improvements in histological scores in APC-treated wounds suggest further study into the effect of APC on second intention wound healing in horses is warranted.
Publisher: Elsevier BV
Date: 06-2018
DOI: 10.1016/J.ANIREPROSCI.2018.03.037
Abstract: Although germ cells from donor rams transplanted into irradiated recipient testes have produced donor derived offspring, efficiency is low. Further optimization of recipient irradiation protocols will add precision to the depletion of recipient spermatogonia prior to germ cell transplant. Three irradiation doses (9,12,15 Gy) were administered to ram lambs aged 14 weeks (Group 1) and 20 weeks (Group 2), then testicular biopsies were collected 1, 2 and 3 months after irradiation. At 1 month after irradiation of Group 1, only the largest dose (15 Gy) reduced spermatogonia numbers below 10% of non-irradiated controls, whereas in Group 2 lambs, each irradiation dose reduced spermatogonia below 10% of controls. In both Groups, fewer differentiated germ cells were present in seminiferous tubules compared to controls. At 2 months after irradiation, spermatogonia numbers in both Groups increased more than sixfold to be similar to controls, whereas fewer differentiated germ cells were present in the tubules of both Groups. At 3 months in Group 1, each irradiation dose reduced spermatogonia numbers to <30% of controls and fewer tubules contained differentiated germ cells. Lesser expression of spermatogonial genes, VASA and UCHL-1, was observed in the 15 Gy group. In Group 2, only 12 Gy treated tubules contained fewer spermatogonia. Knowledge of these subtle differences between age groups in the effect of irradiation doses on spermatogonia or differentiated germ cell numbers and the duration of recovery of spermatogonia numbers after irradiation will aid the timing of germ cell transplants into prepubertal recipient lambs.
Publisher: Wiley
Date: 23-06-2009
Publisher: S. Karger AG
Date: 1980
DOI: 10.1159/000172785
Abstract: Glomerular cultures from mice have been established and the various cells associated with them observed microscopically by phase contrast time-lapse cinematography, after histological staining and ultrastructurally with the transmission and scanning electron microscope. The most common cell types were large 80–200 µm diameter irregular polyhedral cells appearing as flattened plate-like structures morphologically, possibly of epithelial origin. Smaller 70–100 µm diameter fusiform cells possibly derived from either endothelium or mesangium were also often seen. A third cell type, small 10–20 µm diameter circular, motile and actively phagocytic was especially noticeable in cultures of hybrid New Zealand Black/New Zealand White mice but was not present in appreciable numbers in control cultures from strains without renal disease. This third cell type appeared to have Fc receptors, stained positively with non-specific esterase and by indirect immunofluorescence with specific rabbit anti-mouse macrophage serum and had the morphological appearance of a macrophage by scanning and transmission electron microscopy. It is concluded that cells of macrophage origin are associated with the immune complex glomerulonephritis in these hybrid mice.
Publisher: Wiley
Date: 26-05-2009
Publisher: Wiley
Date: 16-02-2012
Publisher: S. Karger AG
Date: 1989
DOI: 10.1159/000185583
Abstract: In order to elucidate the cells produced from human glomerular cultures, a pre-embedding ultrastructural immunoperoxidase technique was developed to investigate the precise localisation of a panel of monoclonal antibodies specific to human glomerular antigens in situ and used to identify the same antigens in vitro. The results obtained were correlated with the morphological features of the cells demonstrated by scanning electron microscopy. The study was able to show the presence of epithelial and mesangial cells in tissue culture, to confirm previous results indicating that glomerular endothelial cells are not present and to give some insight into the production of different basement membrane components by different cell types.
Publisher: Wiley
Date: 20-08-2010
Publisher: Wiley
Date: 27-05-2012
Publisher: Wiley
Date: 16-02-2011
Publisher: Wiley
Date: 24-07-2012
Publisher: Wiley
Date: 06-2006
Publisher: Wiley
Date: 16-04-2010
Publisher: Wiley
Date: 27-07-2009
Publisher: Wiley
Date: 09-1996
DOI: 10.1111/J.1751-0813.1996.TB15410.X
Abstract: To investigate the effect of two dose rates (200 and 400 ng) of a gonadotrophin releasing hormone (GnRH) vaccine on testicular function. A vaccination dose rate experiment. Two injections were administered 4 weeks apart to six colts in each treatment group. To maintain immunosuppression until the end of the breeding season, a third injection was given if antibody titres fell below 1000. Effective antibody titres were present for 12 to 27 weeks. Testosterone concentrations decreased from 2.22 to 0.31 nmol/L 6 weeks after primary vaccination. Androstenedione concentrations decreased from 1.78 to 0.28 nmol/L 5 weeks after vaccination. Testosterone and androstenedione concentrations above 0.69 and 0.87 nmol/L were attained 31 to 43 weeks after vaccination. Mean scrotal widths and lengths decreased over 29 weeks from 9.2 cm and 9.7 cm to 6.7 cm and 7.6 cm. At surgical castration these dimensions were 10.1 cm and 11.0 cm. Mean semen characteristics before vaccination and after recovery were: gel-free volume 16.5 and 13.5 mL, sperm concentration 295.5 x 10(6) and 315.6 x 10(6)/mL, total sperm per ejaculate 4041 x 10(6) and 4657 x 10(6) and live normal spermatozoa 32% and 60%. Histologically, the testes showed active spermatogenesis. The mean testicular parenchyma weights for the 200 and 400 mg groups were 129.0 g and 109.8 g. Daily sperm production per testis and per gram of testis for the 200 and 400 mg groups were 3.7 x 10(8) and 2.8 x 10(6), and 2.3 x 10(8) and 2.0 x 10(6). Both dose rates suppressed testicular function. Data showed that the vaccine effects were reversible. In idual immune response was less varied in the 200 mg group. Further work is necessary to achieve a less variable response in the immunosuppression of testicular function.
Publisher: Wiley
Date: 21-03-2011
Publisher: Wiley
Date: 24-09-2012
Publisher: Oxford University Press (OUP)
Date: 09-1986
DOI: 10.1095/BIOLREPROD35.2.425
Abstract: Ethylene dimethane sulphonate (DS) administered to adult male rats in a single dose of 75 mg/kg body weight results in a rapid destruction of Leydig cells which, in turn, is associated with a marked decline in levels of serum testosterone. For 24-72 h after treatment with EDS (post-EDS) the Leydig cells undergo degenerative changes consisting of chromatin condensation and cytoplasmic vacuolation, and testicular macrophages progressively remove Leydig cells from the intertubular tissue by phagocytosis. This results in the total absence of Leydig cells on Days 7-14 and the absence of any detectable specific 125I-hCG binding to testis homogenates. Associated with the low levels of serum testosterone, levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in serum rise, LH to levels found in castrate rats. Morphometric and 125I-hCG binding studies indicate that a new generation of Leydig cells develop from Day 21 and reach control levels by Day 49. Morphologic observations suggest that the Leydig cells arise by differentiation from a pool of connective tissue cells that includes fibroblasts, lymphatic endothelial cells and pericytes. The new Leydig cells, which appear around Day 21 post-EDS, have the features of fetal Leydig cells. The latter appear to transform into Leydig cells typical of normal adult rats between 35-49 days post-EDS. The differentiation of new Leydig cells is associated with a reestablishment of normal levels of testosterone 21 days post-EDS. Serum LH and FSH return to normal at 28 days and 49 days respectively.
Publisher: Wiley
Date: 22-03-2012
Publisher: Wiley
Date: 22-06-2011
DOI: 10.1111/J.1751-0813.2011.00796.X
Abstract: Disease control during the colonial period in Australia · Neurological diseases of ruminant livestock in Australia · Coxiella burnetii in beef cattle in Queensland · Desmotomy for flexural deformity in Thoroughbreds · Acute myeloid leukaemia in a Thoroughbred foal · Growth variants of Avibacterium paragallinarum · Volvulus in a dugong.
Publisher: Wiley
Date: 25-06-2012
Publisher: Wiley
Date: 20-08-2009
Publisher: Wiley
Date: 21-11-2010
Publisher: Wiley
Date: 16-02-2012
Publisher: Wiley
Date: 26-05-2015
DOI: 10.1111/AVJ.12331
Abstract: This report documents an outbreak of acute renal failure in a flock of 9-month-old White Suffolk-cross ewe lambs. The mortality rate was moderate but the morbidity was high. The lambs had grazed a wheat stubble paddock in which there were several weed species, including Amaranthus spp. Renal failure in livestock has been reported internationally following the ingestion of Amaranthus spp. and although it has previously been suspected in Australia no cases have been documented. It is important for Australian veterinarians and farmers to realise the toxic potential of this group of plants.
Publisher: Wiley
Date: 2015
DOI: 10.1111/AVJ.12295
Publisher: Wiley
Date: 26-03-2014
DOI: 10.1111/AVJ.12172
Publisher: Wiley
Date: 20-09-2010
Publisher: Wiley
Date: 22-02-2009
Publisher: Wiley
Date: 26-09-2014
DOI: 10.1111/AVJ.12256_2
Publisher: Wiley
Date: 2009
DOI: 10.1111/J.1751-0813.2008.01345.X
Abstract: Laboratory reference intervals for Merino lambs ▪ Intradermal cetrimide for nonsurgical mulesing ▪ Carprofen with intradermal cetrimide ▪ Polioencephalomalacia in cattle grazing Brassica plants ▪ Dietary antibiotics for proliferative enteropathy ▪ First description of equine pneumonitis and fetal loss (EPFL) in Australia ▪ Pyruvate kinase deficiency in Abyssinian and Somali cats ▪ Suspected neuropathic pain in dogs ▪ Osteosarcoma of the canine penile bone ▪ Pre weaning morbidity in llamas and alpacas ▪ Previously unreported species of microsporidium in Western Pigmy perch ▪ Granulomatous disease in a nestling parrot ▪ Uterine adenomyosis in an orang‐utan
Publisher: Wiley
Date: 18-02-1978
DOI: 10.1136/VR.102.7.149
Publisher: Wiley
Date: 26-02-2013
DOI: 10.1111/AVJ.12042
Publisher: Wiley
Date: 21-11-2011
Publisher: Wiley
Date: 2006
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Anne Jackson.