ORCID Profile
0000-0003-1785-7302
Current Organisations
Macquarie University
,
Swiss Tropical and Public Health Institute
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Social and Cultural Anthropology | Anthropology
Publisher: Wiley
Date: 30-03-2017
Abstract: The natural products isatropolone A-C (1-3) were reisolated from Streptomyces Gö66, with 1 and 3 showing potent activity against Leishmania donovani. They contain a rare tropolone ring derived from a type II polyketide biosynthesis pathway. Their biosynthesis was elucidated by labeling experiments, analysis of the biosynthesis gene cluster, its partial heterologous expression, and structural characterization of various intermediates. Owing to their 1,5-diketone moiety, they can react with ammonia, amines, lysine, and lysine-containing peptides and proteins, which results in the formation of a covalent bond and subsequent pyridine ring formation. Their fluorescence properties change upon amine binding, enabling the simple visualization of reacted amines including proteins.
Publisher: American Chemical Society (ACS)
Date: 12-07-2010
DOI: 10.1021/ML100120A
Publisher: American Chemical Society (ACS)
Date: 25-08-2017
DOI: 10.1021/ACS.JNATPROD.7B00543
Abstract: Chemical investigation of the marine sponge Ircinia oros yielded four linear furanosesterterpenoids, including the known metabolites ircinin-1 (1) and ircinin-2 (2) and two new compounds, ircinialactam E (3) and ircinialactam F (4). Their chemical structures were elucidated by using a combination of [α]
Publisher: Informa UK Limited
Date: 09-2002
Publisher: SAGE Publications
Date: 06-2022
DOI: 10.1177/11771801221099571
Abstract: Reflecting on the violence in Papua and how this is shaping Papuan lifeworlds and triggers attempts to disengage from Indonesian and Dutch imperialism, we, I Ngurah Suryawan and Jaap Timmer, position ourselves as nationals from colonising states—one current, Indonesia and one historic, Netherlands—in relation to our anthropological research in Papua. We came to the long-drawn-out conflict and growing affirmations of cultural autonomy in Papua from different backgrounds, and this has affected the way in which we try to contribute to remedy decades of violence. Yet, as we will show, we converge in the way we recognise that a key role we can play as anthropologists is to contribute to a better understanding of Papuan cultures and more appreciation of their creative expressions and to enable, for Papuans, a decolonial epistemology.
Publisher: Informa UK Limited
Date: 02-01-2016
Publisher: Wiley
Date: 06-10-2015
DOI: 10.1002/OCEA.5110
Publisher: Springer Netherlands
Date: 2012
Publisher: American Chemical Society (ACS)
Date: 21-03-2013
DOI: 10.1021/JM400009C
Publisher: Wiley
Date: 03-2023
DOI: 10.1002/OCEA.5356
Abstract: This essay explores the post‐World War Two anti‐colonial Maasina Rule in north Malaita, Solomon Islands, to show how a church leader Shem Irofa'alu decided to establish a religious movement independent of the state and the traditional evangelical church. Irofa'alu's movement indexes an important moment of culture change towards increasing enthusiasm for the often‐overlooked Christianity‐based forms of sovereignty in the region. It highlights that Maasina Rule was not only a powerful rupture in social processes, but also sharpened the growing ision between state and church. Irofa'alu's role in Maasina Rule shows that his influence peaked between 1948 and 1950 and then went into rapid decline. This change in fortune coincided with a critical turning point in the colonial government's attempts to end the movement through appeasement. No longer the head of the evangelical church in Malu'u sub‐district and frustrated about the mother church's governance, Irofa'alu retreated to his home area and set about establishing a new church, Boboa (‘Foundation’), his first attempt at organizing a self‐governing assembly before introducing Jehovah's Witnesses in north Malaita. In later years, Irofa'alu became a prophet‐exemplar for new generations of religious leaders trying to establish Malaitan sovereignties based on their own power to move the truth of prophecies away from foreign state and church organizations.
Publisher: University of California Press
Date: 2014
Abstract: The notion that forebears of Solomon Islanders might be descendants of the Ten Lost Tribes of Israel is widespread among To’abaita speakers in North Malaita, and it features in a particular way in the theology of the popular All Peoples Prayer Assembly (APPA), also known as the Deep Sea Canoe Movement. Prominent in this boast of an Israelite genealogy is a utopian fantasy of a just “Israel” grounded in the ancestral soil of the island of Malaita. This article describes the APPA worldview as an alternative modernity that is meaningful to the To’abaitans because it provides a new sense of self and a shared destiny. Although APPA’s theology relates to the people’s socio-economic concerns, it reveals more clearly the continuity of some key cultural models through changing global influences, local histories and cultural dynamics.
Publisher: Wiley
Date: 04-09-2018
DOI: 10.1002/9781118924396.WBIEA1374
Abstract: We all live with some idea of justice that shapes in profound ways the ways we relate to each other and what we regard as right and wrong. Legal pluralism focuses on the rules governing this and recognizes that, even if such rules are formally instituted, social organization, jobs, projects, nation building, and so on also proceed through effective informal understandings and improvisations. Following a checkered history since the colonial period, the concept of legal pluralism currently makes reference to the whole aggregate of norms of social life and control, using the distinctions people make even as they acknowledge an analytical distinction between the state and nonstate as different sites from which norms and rules emanate. Unlike its past focus on the law, anthropologists working in this field now focus less on special court cases, professional rationalizations, and contested forms of regulation than on everyday understandings.
Publisher: Informa UK Limited
Date: 08-07-2014
Publisher: Informa UK Limited
Date: 11-2012
Publisher: Wiley
Date: 27-10-2017
DOI: 10.1111/TAJA.12258
Publisher: American Chemical Society (ACS)
Date: 17-07-2014
DOI: 10.1021/JM500191U
Abstract: A whole-organism screen of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promising compounds for medicinal chemistry optimization. One of these classes of compounds we termed the pyridyl benzamides. While the initial hit had an IC50 of 12 μM, it was small enough to be attractive for further optimization, and we utilized three parallel approaches to develop the structure-activity relationships. We determined that the physicochemical properties for this class are generally favorable with particular positions identified that appear to block metabolism when substituted and others that modulate solubility. Our most active compound is 79, which has an IC50 of 0.045 μM against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 times less active against the mammalian L6 cell line.
Publisher: American Chemical Society (ACS)
Date: 16-06-2011
DOI: 10.1021/JM200227R
Abstract: A novel class of antimalarial pyrido[1,2-a]benzimidazoles were synthesized and evaluated for antiplasmodial activity and cytotoxicity following hits identified from screening commercially available compound collections. The most active of these, TDR86919 (4c), showed improved in vitro activity vs the drug-resistant K1 strain of Plasmodium falciparum relative to chloroquine (IC(50) = 0.047 μM v 0.17 μM) potency was retained against a range of drug-sensitive and drug-resistant strains, with negligible cytotoxicity against the mammalian (L-6) cell line (selectivity index of >600). 4c and several close analogues (as HCl or mesylate salts) showed significant efficacy in P. berghei infected mice following both intraperitoneal (ip) and oral (po) administration, with >90% inhibition of parasitemia, accompanied by an increase in the mean survival time (MSD). The pyrido[1,2-a]benzimidazoles appeared to be relatively slow acting in vivo compared to chloroquine, and metabolic stability of the alkylamino side chain was identified as a key issue in influencing in vivo activity.
Publisher: Informa UK Limited
Date: 11-08-2017
Publisher: Elsevier BV
Date: 11-2017
DOI: 10.1016/J.ENVRES.2017.07.044
Abstract: Estimating exposure to particulate matter (PM
Publisher: Wiley
Date: 20-10-2013
DOI: 10.1002/OCEA.5018
Publisher: Wiley
Date: 20-10-2013
DOI: 10.1002/OCEA.5017
Publisher: Informa UK Limited
Date: 03-04-2014
Publisher: American Chemical Society (ACS)
Date: 30-08-2015
DOI: 10.1021/ACS.JMEDCHEM.5B00438
Abstract: From a whole-organism high throughput screen of approximately 87000 compounds against Trypanosoma brucei brucei, we recently identified eight new unique compounds for the treatment of human African trypanosomiasis. In an effort to understand the structure-activity relationships around these compounds, we report for the first time our results on a new class of trypanocides, the pyrazine carboxamides. Attracted by the low molecular weight (270 g·mol(-1)) of our starting hit (9) and its potency (0.49 μM), the SAR around the core was explored, leading to compounds having an EC50 as low as 25 nM against T. b. brucei and being more than 1500 times less toxic against mammalian L6 and HEK293 cell lines. The most potent compounds in the series were exquisitely selective for T. brucei over a panel of other protozoan parasites, showing an excellent correlation with the human infective parasite Trypanosoma brucei rhodesiense, the most potent compound (65) having an EC50 of 24 nM. The compounds are highly drug-like and are able to penetrate the CNS, their only limitation currently being their rate of microsomal metabolism. To that effect, efforts to identify potential metabolites of selected compounds are also reported.
Publisher: MDPI AG
Date: 25-06-2022
DOI: 10.3390/MICROORGANISMS10071287
Abstract: Chagas disease caused by the protozoan Trypanosoma cruzi is endemic to 21 countries in the Americas, effects approximately 6 million people and on average results in 12,000 deaths annually. Human African Trypanosomiasis (HAT) is caused by the Trypanosoma brucei sub-species, endemic to 36 countries within sub-Saharan Africa. Treatment regimens for these parasitic diseases are complicated and not effective against all disease stages thus, there is a need to find improved treatments. To identify new molecules for the drug discovery pipelines for these diseases, we have utilised in vitro assays to identify compounds with selective activity against both T. cruzi and T.b. brucei from the Medicines for Malaria Venture (MMV) Pathogen Box compound collection. To prioritise these molecules for further investigation, temporal and wash off assays were utilised to identify the speed of action and cidality of compounds. For translational relevance, compounds were tested against clinically relevant T.b. brucei subspecies. Compounds with activity against T. cruzi cytochrome P450 (TcCYP51) have not previously been successful in clinical trials for chronic Chagas disease thus, to deprioritise compounds with this activity, they were tested against recombinant TcCYP51. Compounds with biological profiles warranting progression offer important tools for drug and target development against kinetoplastids.
Publisher: American Chemical Society (ACS)
Date: 30-01-2017
DOI: 10.1021/ACS.ORGLETT.6B03796
Abstract: Nematophin, a known antibiotic natural product against Staphylococcus aureus for almost 20 years, is produced by all strains of Xenorhabdus nematophila. Despite its simple structure, its biosynthesis was unknown. Its biosynthetic pathway is reported using heterologous production in Escherichia coli. Additionally, the identification, structure elucidation, and biosynthesis of six extended nematophin derivatives from Xenorhabdus PB62.4 carrying an additional valine are reported. Preliminary bioactivity studies suggest a biological role of these compounds in the bacteria-nematode-insect symbiosis.
Publisher: Brill
Date: 2008
DOI: 10.1163/22134379-90003665
Abstract: I Wayan Arka, Malcolm Ross (eds) The many faces of Austronesian voice systems Some new empirical studies (René van den Berg) H.W. Dick Surabaya, city of work A socioeconomic history, 1900-2000 (Peter Boomgaard) Josiane Cauquelin The aborigines of Taiwan: the Puyuma From headhunting to the modern world. (Wen-Teh Chen) Mark Turner, Owen Podger (with Maria Sumardjono and Wayan K. Tirthayasa) Decentralisation in Indonesia Redesigning the state (Dorian Fougères) Jérôme Samuel Modernisation lexicale et politique terminologique Le cas de l’Indonésien (Arndt Graf) Nicholas J. White British business in post-colonial Malaysia, 1957-70: neo-colonialism or disengagement? (Karl Hack) Chin Peng Alias Chin Peng My side of history As told to Ian Ward and Norma Miraflor (Russell Jones) C.C. Chin, Karl Hack (eds) Dialogues with Chin Peng New light on the Malayan Emergency (Russell Jones) Saw Swee-Hock Population policies and programmes in Singapore (Santo Koesoebjono) Domenyk Eades A grammar of Gayo A language of Aceh, Sumatra (Yuri A. Lander) Derek Johnson, Mark Valencia (eds) Piracy in Southeast Asia Status, issues, and responses (Carolyn Liss) Niclas Burenhult A grammar of Jahai (James A. Matisoff) Ann R. Kinney, Marijke J. Klokke, Lydia Kieven (photographs by Rio Helmi) Worshiping Siva and Buddha The temple art of East Java (Dick van der Meij) Ruben Stoel Focus in Manado Malay Grammar, particles, and intonation (Don van Minde) Pamela J. Stewart, Andrew Strathern (eds) Expressive genres and historical change Indonesia, Papua New Guinea and Taiwan. (Dianne van Oosterhout) Johszua Robert Mansoben Sistem politik tradisional di Irian Jaya, Indonesia Studi perbandingan (Anton Ploeg) Timothy B. Barnard (ed.) Contesting Malayness Malay identities across boundaries (Nathan Porath) Joel Bradshaw, Francisc Czobor (eds) Otto Dempwolff’s grammar of the Jabêm language in New Guinea (Ger Reesink) Jon Fraenkel The manipulation of custom From uprising to intervention in the Solomon Islands (Jaap Timmer) Clive Moore Happy isles in crisis The historical causes for a failing state in Solomon Islands, 1998-2004 (Jaap Timmer) Peter Burns The Leiden legacy Concepts of law in Indonesia (Bryan S. Turner) Terry Crowley Bislama reference grammar (Kees Versteegh) REVIEW ESSAY Matthew Isaac Cohen Transnational and postcolonial gamelan Lisa Gold Music in Bali Margaret J. Kartomi The Gamelan Digul and the prison c musician who built it An Australian link with the Indonesian revolution Marc Perlman Unplayed melodies Javanese gamelan and the genesis of music theory Ted Solís (ed.) Performing ethnomusicology Teaching and representation in world music ensembles Henry Spiller Gamelan The traditional sounds of Indonesia Andrew N. Weintraub Power plays Wayang golek theater of West Java REVIEW ESSAY Victor T. King People and nature in Borneo Tim Bending Penan histories Contentious narratives in upriver Sarawak Rajindra K. Puri Deadly dances in the Bornean rainforest Hunting knowledge of the Penan Benalui, 2005 Reed L. Wadley (ed.) Histories of the Borneo environment Economic, political and social dimensions of change and continuity In: Bijdragen tot de Taal-, Land- en Volkenkunde no. 162 (2006), no: 4, Leiden
Publisher: Wiley
Date: 05-08-2013
Publisher: Wiley
Date: 02-10-2013
Publisher: Brill
Date: 2014
Publisher: Informa UK Limited
Date: 2015
Publisher: Wiley
Date: 07-2016
DOI: 10.1002/OCEA.5131
Publisher: Wiley
Date: 11-2010
Publisher: Informa UK Limited
Date: 19-09-2014
Publisher: Informa UK Limited
Date: 23-05-2014
Publisher: Duke University Press
Date: 2000
Abstract: Imyan people of the southwestern Bird's Head Peninsula of Irian Jaya await an event that promises wealth, justice, and a new world order: Jesus Christ's kingdom on earth. Millennial beliefs among the Imyan derive from a potent blend of Christian doctrine, ancestral transgressions, relationships with sky deities, and a long history of contact with the kingdom of Sailolof, a tributary principality of the North Moluccan sultanate of Tidore. By analyzing the present-day Imyan fear of a growing ide between heaven and earth, this article shows how male Imyans reconcile their current marginality within the Indonesian state to a future that is rooted in local myth and Christian doctrine.
Publisher: MDPI AG
Date: 21-03-2014
Publisher: American Society for Microbiology
Date: 03-2016
DOI: 10.1128/AAC.02116-15
Abstract: The screening of a focused library identified FTY720 (Fingolimod Gilenya) as a potent selective antitrypanosomal compound active against Trypanosoma brucei gambiense and T. brucei rhodesiense , the causative agents of human African trypanosomiasis (HAT). This is the first report of trypanocidal activity for FTY720, an oral drug registered for the treatment of relapsing multiple sclerosis, and the characterization of sphingolipids as a potential new class of compounds for HAT.
Publisher: Public Library of Science (PLoS)
Date: 29-11-2012
Publisher: American Chemical Society (ACS)
Date: 03-10-2011
DOI: 10.1021/JO201654H
Abstract: Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2)-D (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A-D is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum.
Publisher: Oxford University Press (OUP)
Date: 25-06-2012
Abstract: The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class of antimalarials. This molecule, ACT-213615, potently inhibits in vitro erythrocytic growth of all tested Plasmodium falciparum strains, irrespective of their drug resistance properties, with half-maximal inhibitory concentration (IC(50)) values in the low single-digit nanomolar range. Like the clinically used artemisinins, the compound equally and very rapidly affects all 3 asexual erythrocytic parasite stages. In contrast, microarray studies suggest that the MOA of ACT-213615 is different from that of the artemisinins and other known antimalarials. ACT-213615 is orally bioavailable in mice, exhibits activity in the murine Plasmodium berghei model and efficacy comparable to that of the reference drug chloroquine in the recently established P. falciparum SCID mouse model. ACT-213615 represents a new class of potent antimalarials that merits further investigation for its clinical potential.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4MD00406J
Abstract: The synthesis of a compound library based on a high throughput screening hit led to the discovery of several potent anti-trypanosomal agents.
Publisher: Informa UK Limited
Date: 09-2013
Publisher: Informa UK Limited
Date: 08-2011
Publisher: Elsevier BV
Date: 08-2013
DOI: 10.1016/J.EJMECH.2013.05.007
Abstract: A whole organism high-throughput screen of approximately 87,000 compounds against Trypanosoma brucei brucei led to the recent discovery of several novel compound classes with low micromolar activity against this organism and without appreciable cytotoxicity to mammalian cells. Herein we report a structure-activity relationship (SAR) investigation around one of these hit classes, the 3-(oxazolo[4,5-b]pyridin-2-yl)anilides. Sharp SAR is revealed, with our most active compound (5) exhibiting an IC₅₀ of 91 nM against the human pathogenic strain T.b. rhodesiense and being more than 700 times less toxic towards the L6 mammalian cell line. Physicochemical properties are attractive for many compounds in this series. For the most potent representatives, we show that solubility and metabolic stability are key parameters to target during future optimisation.
Publisher: Wiley
Date: 11-2009
Publisher: Elsevier BV
Date: 08-2017
DOI: 10.1016/J.BMC.2017.06.029
Abstract: Marine meroterpenoids, thiaplidiaquinones A and B and their respective non-natural dioxothiazine regioisomers have been shown to inhibit mammalian and protozoal farnesyltransferase (FTase) with the regioisomers exhibiting activity in the nanomolar range. In order to explore the structure-activity relationship (SAR) of this class of marine natural products, analogues of thiaplidiaquinones A and B and their regioisomers were synthesised, with variation in the number of isoprene units present in their side chains to afford prenyl and farnesyl analogues. The previously reported geranyl series of compounds were found to be the most potent FTase inhibitors closely followed by the novel farnesyl series. The prenyl series exhibited the most potent anti-plasmodial activity but the series was also the most cytotoxic. Overall, the farnesyl series exhibited moderate anti-plasmodial activity with one analogue, 14 also exhibiting low cytotoxicity, identifying it as a scaffold worthy of further exploration.
Publisher: American Society for Microbiology
Date: 07-2009
DOI: 10.1128/AAC.01568-08
Abstract: High-throughput screening of 100,000 lead-like compounds led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation. Hits from five of these chemical classes have been developed further through different combinations of preliminary structure-activity relationship rate probing and assessment of antiparasitic activity, cytotoxicity, and chemical and in vitro metabolic properties. This has led to the identification of novel TR inhibitor chemotypes that are drug-like and display antiparasitic activity. For one class, a series of analogues have displayed a correlation between TR inhibition and antiparasitic activity. This paper explores the process of identifying, investigating, and evaluating a series of hits from a high-throughput screening c aign.
Publisher: ANU Press
Date: 2008
Publisher: American Chemical Society (ACS)
Date: 19-09-2016
DOI: 10.1021/ACS.JMEDCHEM.6B00442
Abstract: The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently available to treat these neglected diseases leave much to be desired. Herein we report optimization of a novel class of N-(2-(2-phenylthiazol-4-yl)ethyl)amides, carbamates, and ureas, which rapidly, selectively, and potently kill both species of trypanosome. The mode of action of these compounds is unknown but does not involve CYP51 inhibition. They do, however, exhibit clear structure-activity relationships, consistent across both trypanosome species. Favorable physicochemical parameters place the best compounds in CNS drug-like chemical space but, as a class, they exhibit poor metabolic stability. One of the best compounds (64a) cleared all signs of T. cruzi infection in mice when CYP metabolism was inhibited, with sterile cure achieved in one mouse. This family of compounds thus shows significant promise for trypanosomiasis drug discovery.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MD00277A
Abstract: African sleeping sickness is a potentially fatal neglected disease affecting sub-Saharan Africa.
Start Date: 2015
End Date: 06-2019
Amount: $125,144.00
Funder: Australian Research Council
View Funded Activity