ORCID Profile
0000-0001-7539-3126
Current Organisations
CNRS Délégation Midi-Pyrénées
,
Steadman Philippon Research Institute
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Publications
A nucleotidyltransferase toxin inhibits growth ofMycobacterium tuberculosisthrough inactivation of tRNA acceptor stems
Publisher: American Association for the Advancement of Science (AAAS)
Date: 31-07-2020
Abstract: The human pathogen Mycobacterium tuberculosis produces a toxin that can stall bacterial growth by blocking the activity of tRNAs.
Function, evolution, and structure of J-domain proteins
Publisher: Springer Science and Business Media LLC
Date: 26-11-2018
Quantifiable Imaging Biomarkers for Evaluation of the Posterior Cruciate Ligament Using 3-T Magnetic Resonance Imaging
Publisher: SAGE Publications
Date: 04-2016
Abstract: Quantitative magnetic resonance imaging (MRI) techniques, such as T2 and T2 star (T2*) mapping, have been used to evaluate ligamentous tissue in vitro and to identify significant changes in structural integrity of a healing ligament. These studies lay the foundation for a clinical study that uses quantitative mapping to evaluate ligaments in vivo, particularly the posterior cruciate ligament (PCL). To establish quantitative mapping as a clinical tool for identifying and evaluating chronic or acute PCL injuries, T2 and T2* values first must be determined for an asymptomatic population. To quantify T2 and T2* mapping properties, including texture variables (entropy, variance, contrast, homogeneity), of the PCL in an asymptomatic population. It was hypothesized that biomarker values would be consistent throughout the ligament, as measured across 3 clinically relevant subregions (proximal, middle, and distal thirds) in the asymptomatic cohort. Cross-sectional study Level of evidence, 4. Unilateral knee MRI scans were acquired for 25 asymptomatic subjects with a 3.0-T MRI system using T2 and T2* mapping sequences in the sagittal plane. The PCL was manually segmented and ided into thirds (proximal, middle, and distal). Summary statistics for T2 and T2* values were calculated. Intra- and interrater reliability was assessed across 3 raters to 2 time points. The asymptomatic PCL cohort had mean T2 values of 36.7, 29.2, and 29.6 ms in the distal, middle, and proximal regions, respectively. The distal PCL exhibited significantly higher mean, variance, and contrast and lower homogeneity of T2 values than the middle and proximal subregions ( P .05). T2* results exhibited substantial positive skew and were therefore presented as median and quartile (Q) values. Median T2* values were 7.3 ms (Q1-Q3, 6.8-8.9 ms), 7.3 ms (Q1-Q3, 7.0-8.5 ms), and 7.3 ms (Q1-Q3, 6.4-8.2 ms) in the distal, middle, and proximal subregions, respectively. This is the first study to identify T2 and T2* mapping values, and their texture variables, for the asymptomatic PCL. The distal third of the PCL had significantly greater T2 values than the proximal or middle thirds. T2 and T2* values of the asymptomatic PCL can provide a baseline for comparison with acute and chronic PCL injuries in future studies.
Modelling biological regions from multi‐species and environmental data
Publisher: Wiley
Date: 11-2013
DOI: 10.1002/ENV.2245
Related Organisations
Steadman Philippon Research Institute
Location: United States of America
Related Funding Activities
No related grants have been discovered for Pierre GENEVAUX.